Cambridge Isotope Laboratories, Inc. Working with IROA Technologies LLC to Develop and Distribute IROA® Biochemical Quantitation Kits

Isotopic ratio outlier analysis (IROA) is an innovative technology that is designed to overcome the analytical challenges of untargeted/targeted metabolic profiling. These challenges minimally pertain to analytical variance, artifactual peaks, and metabolite identification. The basic IROA protocol uses metabolic incorporation of heavy (95% ¹³C) and light (5% ¹³C) nutrients, such as D-glucose and other carbon energy sources, to give rise to unique labeling patterns that can be readily identified and distinguished by mass spectrometry. Such a method would be useful in interlaboratory qualitative/quantitative evaluations, if widely available. 

The IROA Biochemical Quantitation Kits (basic, phenotypic, and fluxomic) contain the reagents and tools necessary for successful metabolic labeling, identification, and quantitation of metabolites in various cell populations and biological samples.

Kit Features and Benefits

• Eliminates technical and analytical variance → increases reliability
• Removes artifacts and noise → increases precision and determination of metabolome
• Reproducible identification of knowns/unknowns  
• Accurate, relative quantitation
• Automated solution (via IROA's ClusterFinder™ software)  
• Easy statistical interpretation of sample results (via IROA's Assay Portal)  
• Broad sample applicability with experimental perturbations being user-defined

Click here to learn more about the IROA Biochemical Quantitation Kits.

About IROA Technologies LLC
IROATECH develops analytical tools to simplify the measurement of metabolites for multiple applications including general research, diagnostics, toxicology, agriculture, and bioprocess.  IROATECH markets the IROA Biochemical Quantitation kits together with their ClusterFinder™ software (for data analysis) and their Assay Portal (for advanced statistical analysis and interpretation). iroatech.com