How Close Are We to Complete Annotation of Metabolomes?

Viant, M.R.; Kurland, I.J.; Jones, M.R.; et al.

Efforts to identify and annotate an organism's metabolome are continuing through untargeted, one-dimensional and multidimensional, MS-based methodologies. Coordinated advancements have been facilitated by the emergence of international task groups, such as the Model Organism Metabolomes. In this review, Dunn et al. summarize the current status of metabolome characterization, its reporting, and pertinent analytical strategies developed therein.