NMR- and MS-based Stable Isotope-resolved Metabolomics and Applications in Cancer Metabolism

Lane, A.N.; Higashi, R.M.; Fan, T.W.

In this article, Lane et al. reviews the stable isotope resolved metabolomic (SIRM) methods for cancer metabolism studies. A multitude of stable isotope-labeled tracers are discussed herein for pathway mapping and qualitative/quantitative analysis of metabolic panels via high resolution MS and NMR spectroscopy techniques. In addition, current and emerging applications are summarized, while insights into future directions for tracer implementation, methodology, and informatics are also noted.

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