Biochemical Pathways Affected by Mitochondrial Stress

Bao, X.R.; Ong, S.E.; Goldberger O.; et al. 

In a landmark study, Mootha VK et al. integrated metabolomic, proteomic, and RNA profiling strategies to identify hypotheses of the biochemical pathways affected by mitochondrial stress. The results indicated a link between mitochondrial dysfunction and serine/homocysteine metabolism. Further examination of Ser biosynthesis and transsulfuration revealed mechanisms by which mitochondrial dysfunction might compromise one-carbon synthesis in mammalian cells.