Historical and Contemporary Stable Isotope Tracer Approaches to Studying Mammalian Protein Metabolism

Wilkinson, D.J. 

A formative article by Daniel Wilkinson of the University of Nottingham provided a historical perspective on the evolution of stable isotope tracers in relation to MS-based technological advancements. The impetus of the highlighted studies was to investigate in vivo mammalian metabolism (e.g., protein, lipid), either at a whole body or analyte-specific level. The future of such research is broad, with its potential impact in clinical arenas and biomarker diagnostics additionally discussed in the context of MS ’omics research.