- 18O Labeling
The incorporation of two 18O atoms into each C-terminus of peptides derived from proteolytic digestion of biological samples has emerged as one of the leading global labeling strategies used in comparative quantitative proteomics. The success of the technique is due in part to the relative low cost of 18O water, the resulting +4 Dalton mass increase in molecular weight for the “heavy” peptide, and co-elution of 18O/16O peptide pairs from reverse-phase HPLC.
Auclair, J.R.; Somasundaran, M.; Green, K.M. 2012. Mass spectrometry tools for analysis of intermolecular interactions. Methods Mol Biol., 896:387-98. PMID: 22821539
Andrew Percy, PhD
Senior Applications Chemist - Mass Spectrometry
Dr. Andrew Percy is the Senior Applications Chemist for Mass Spectrometry. His responsibilities minimally involve overseeing product development, identifying new product market opportunities, assisting in the analysis of products for MS ‘omics applications, and providing technical support to customers.More
Proteomics Product Manager, Deuterated Reagents & Intermediates Product Manager, China Sales - Research Products
Tasha Agreste, Product Manager for the Proteomics product line, has been with CIL since 1989. During her tenure at CIL, Tasha has held various positions including customer service, sales and marketing, where she has proven to be instrumental in enhancing CIL’s customer relationships.More