Testimonials

"Isotopically engineered materials are essentials for quantum technologies. Availability of isotopically purified methane will enable growth of ultrapure diamond allowing to reach long coherence time of diamond spin qubits,"

"I have worked with CIL for more than 15 years to design and provide the best and most suitable stable isotope standards for the newborn and metabolic screening community. Their standards are the highest quality and customer service is excellent."

"Stable isotopes, together with mass spectrometry, provide the clinical chemist with the tools to develop and utilize the most accurate and precise laboratory tests possible in research, screening, and diagnostics.  I have worked with CIL for more than 15 years to design and provide the best and most suitable stable isotope standards for the newborn and metabolic screening community.  Their standards are the highest quality and customer service is excellent."

Donald H. Chace, PhD, MSFS, FACB
The Pediatrix Center for Research
Education, and Quality
Pediatrix Medical Group

“Using highly enriched materials decreases the amount of unlabeled analog introduced into the mass spectrometer. As a result, using 99% enriched amino acids will improve the accuracy and useful dynamic range for MS-based quantitative proteomic methods compared to using amino acids with lower enrichments.”

“Using highly enriched materials decreases the amount of unlabeled analog introduced into the mass spectrometer. As a result, using 99% enriched amino acids will improve the accuracy and useful dynamic range for MS-based quantitative proteomic methods compared to using amino acids with lower enrichments.”

Michael Burgess
Biochemist III
Broad Institute, Cambridge, MA

"CIL and Cassia have developed the most extensive product line of stable isotope-labeled RNA and DNA triphosphates, DNA phosphoramidites and other related compounds."

Cassia LLC was founded in 2005 by noted NMR spectroscopist Dr. Jamie Williamson and Dr. Lincoln Scott. CIL and Cassia have a special relationship which makes use of CIL’s isotopic material production and marketing and Cassia’s special knowledge of RNA and DNA biosynthesis. Since 2005, CIL and Cassia have developed the most extensive product line of stable isotope-labeled RNA and DNA triphosphates, DNA phosphoramidites, and other related compounds. All of these products are routinely available for immediate shipment from stock at CIL.

“We have been using CIL products for years and appreciate the competitive pricing, outstanding quality control, friendly customer service and timely delivery of the wide range of products that CIL provides for our protein folding and structural studies.”

Dr. Lila Gierasch

Department of Biochemistry and Molecular Biology

University of Massachusetts Amherst

“Huntington Medical Research Institute thanks Cambridge Isotope for the support of its Enhanced Magnetic Resonance Program. CIL’s help was crucial in the molecular synthesis of the precursor of the first metabolic PHIP (Parahydrogen Induced Polarization) reagent for real-time hyperpolarized imaging and spectroscopy.”

Dr. Pratip Bhattacharya

Enhanced Magnetic

Resonance Laboratory

Huntington Medical

Research Institutes

Pasadena, CA

“We’ve been using CIL’s perdeuterated rNTPs for many years to facilitate NMR studies of larger RNAs. Their newer products, which include partially deuterated rNTPs, have been extraordinarily helpful, and have enabled high resolution NMR structural studies of RNAs that were previously intractable.”

Dr. Michael Summers

Howard Hughes Medical Institute

University of Maryland

Baltimore County

“We have been a loyal customer of CIL for stable isotope-labeled products for our research in the study of proteins. CIL has provided reliable, in stock, high quality products for our lab. We have enjoyed a nice working relationship with CIL over the years.”

Dr. Ravi Pratap Barnwal

Research Associate, Department of Chemisty

University of Washington

“As the leading developer of stable isotope-based biomarkers, it is essential that we have reliable partners providing us with high-quality clinical and cGMP-grade materials. For over 10 years CIL has consistently provided us with high-quality clinical and research-grade stable isotope tracers for the development of our novel kinetic-based tests.”

Executive Vice President of Research and Development

KineMed, Inc.

“We concluded that CIL is the best-positioned company in the world to meet our future expected demands in terms of both material quantity and material quality. As we expand the use of our SILK™-based biomarkers beyond research services and into clinical diagnostic applications, CIL will be an instrumental partner to help us qualify our test kits to produce L-leucine under GMP scaled-up conditions.”

"Cambridge Isotope Labs has been our supplier for deuterated NMR solvents for more than 15 years. CIL has been a reliable supplier of high quality deuterated solvents. Their knowledgeable and friendly customer service team is able to fill my orders in a timely manner. I have developed a great working relationship with CIL. I am able to pass that exceptional service onto the researchers in the chemistry department through competitive pricing and fast dependable delivery."

Paul Liberatore

Stockroom Manager

Chemistry Department, University of Rochester

Rochester, NY

“The use of isotopically labeled standards is key to the work we do under the GAPS (Global Atmospheric Passive Sampling) Network, where we investigate both legacy POPs and new priority chemicals in air at the global-scale. The use of labeled standards helps to ensure the integrity of our analytical methods and for estimating sampling rates for our PUF disk passive air samplers. ”

Tom Harner

Senior Research Scientist

The Air Quality Processes Research Section (ARQP) of Environment and Climate Change Canada (ECCC)

“When my lab makes labeled RNA, we count on high yields and purity. We have been using 13C / 15N ribonucleotide triphosphates (rNTPs) and selectively deuterated rNTPs from CIL for the past 10 years. We have always been very happy with the performance and quality of the CIL rNTPs. They are the gold standard.” Dr. Samuel Butcher Department of Biochemistry University of Wisconsin-Madison

“When my lab makes labeled RNA, we count on high yields and purity. We have been using 13C / 15N ribonucleotide triphosphates (rNTPs) and selectively deuterated rNTPs from CIL for the past 10 years. We have always been very happy with the performance and quality of the CIL rNTPs. They are the gold standard.”

“The use of ¹⁵N Spirulina diet for generating SILAM mice was very straightforward and effective. The mice seemed to prefer the Spirulina chow to their normal diet, and behaved and bred normally over multiple generations while consuming this food. Labeling efficiency was very high (~98% enrichment) after only a single generation.”

“To measure proteome-wide protein turnover in flies and mice we have used a synthetic diet enriched with L-Leucine (5,5,5-D₃) from CIL. The material is extremely cost effective and because of the high frequency of leucine in tryptic peptides, it enables us to use isotopomer distribution analysis to correct for differences in the precursor pool. These are challenging experiments to perform, with lots of details to worry about. Thankfully we have never had to worry about the quality of our stable isotope-labeled material from CIL.”

Michael J. MacCoss, PhD
Associate Professor
University of Washington
Department of Genome Studies

“The addition of SILAM standards prepared from CIL’s MouseExpress^® brain tissue to subcellular fractionation and targeted LC-SRM/MS methodologies represents an essential powerful new tool for the study of neuropsychiatric illness.”

“We have used the MouseExpress^® L-Lysine (¹³C₆, 99%) Mouse Feed Labeling Kit from Cambridge Isotope Labs (CIL) to label a colony of C57BL6 mice. We achieved full labeling efficiency by F2 generation in the muscle tissue, our tissue of interest, and in all other tissues tested. In addition, CIL’s MouseExpress^® (¹⁵N, 98%) Mouse Feed was used in non-generational labeling of a colony of C57BL6 mice. We achieved full labeling efficiency after 12 weeks of feeding the MouseExpress^® (¹⁵N, 98%) Mouse Feed. These labeled tissues are fueling a variety of studies for multiple principle investigators at our research institute to study Duchenne muscular dystrophy, myositis, urea cycle disorders and vanishing white matter disease. “

“The commercial availability of stable isotope-labeled amino acids with very high isotopic purity has revolutionized quantitative proteomics. From their use in metabolic labeling of cells and rodents for differential discovery proteomics, to their use in synthetic peptides as internal standards for targeted analysis of proteins, isotopically labeled amino acids make it possible to measure, with very high precision, changes in the levels of peptides and the proteins they are derived from in highly complex samples such as cell lysates, tissue and plasma. Cambridge Isotope Labs has been and continues to be a leader in the commercial production of labeled amino acids and other labeled compounds.”

“I have been dealing with Cambridge Isotope Labs for over a decade, and simply put, CIL is the best isotope company out there – best in quality, best in service...”

“With their combination of high quality, extensive catalogue and excellent customer relations, CIL is always our first port of call when sourcing isotopically labelled protected amino acid derivatives.”

“Proteome Sciences has developed and manufactures the isobaric Tandem Mass Tag^® (TMT^®) reagents, which are sold under license by Thermo Fisher Scientific. TMT^® reagents for MS-based proteomics investigations are used worldwide and represent one of our key business activities. To meet increased market needs and to make full advantage of latest MS instrument developments, we continuously evaluate improvement potential together with our partners and key opinion leaders. Heavy isotope-labeled building blocks are key to both guarantee a constant TMT^® product supply to our licensee and to generate new prototypes and TMT^® products. Since we started manufacturing TMT^®’s in large scale in 2008, Cambridge Isotope Labs has consistently been a reliable partner who can provide us with bulk amounts of established precursors and supply custom-tailored precursors for improvement investigation. Their product quality both in chemical purity, isotope enrichment and delivery times have been a sustainable source for our business. We are looking forward to continuing our collaboration with CIL as we develop exciting new tags for enhanced mass spectrometry methods.”

“We have come to depend on CIL to furnish us with high quality reagents during the past few years as our laboratory became interested in the synthesis of a series of isotopically labeled coding agents for quantification in both proteomics and metabolomics. CIL was both knowledgeable and helpful, being willing to listen to our problems and going to their technical staff for solutions. Relationships like this are infrequent today and extremely valuable when you need answers quickly.”

“In our hands, CIL’s BioExpress^® 1000 worked like a charm. The cell growth rate and protein expression level essentially matched the results obtained with Luria broth, and the ¹⁵N labeling efficiency was excellent.”

Tero Pihlajamaa, PhD
Finnish Biological NMR Center
Institute of Biotechnology
University of Helsinki, Finland

“Life is sustained by constant dynamic metabolic adaptations to environmental changes in healthy and disease states. This is the reason why stable isotope-labeled compounds help us to understand kinetics modifications. Thus, we are looking for ‘high quality’ products which can be used safely. Thanks to CIL products, which are delivered quickly after order, with purity analysis and quality control, we have been able to propose new concepts in nutrition. Thus, we are satisfied by their products.”

Professor Yves Boirie
Human Nutrition Unit – INRA / Université d’Auvergne
Human Nutrition Research Center of Auvergne
58 rue Montalembert, 63009 Clermont-Ferrand, France

“I have been extremely happy with all products and services that we’ve obtained from CIL. All stable isotope reagents have exceeded our expectations. We’ve also obtained custom services from CIL to complete some very challenging studies, and have found CIL flexible and willing to work with us to achieve our goals. In short, I have nothing but positive things to say about our experience with CIL and their products.”

“In our early phthalate work at the CDC, Cambridge Isotope Labs provided custom ¹³C standards quickly and accurately. This allowed the scientists in my lab to do gound-breaking work on human exposures to phthalates that continues today. I thank the Environmental Contaminant Standards new product development team and those great synthetic chemists at CIL.”

"We have been extremely pleased and satisfied with CIL, not only for their quality products and competitive prices, but for their prompt customer service, including getting quotes quickly and fast delivery."

Julie Forman-kay
Senior Scientist, Molecular Structure and Function
Hospital for Sick Children
Professor, Department of Chemistry
University of Toronto

“For many years we have had a strong relationship with CIL. The heavy peptides AQUA standards we produce require the highest quality of raw material, service and technical support, and CIL never failed to deliver. When we asked CIL to adapt the specifications of their products so we could meet the needs of our customers, they reacted immediately, and within a couple of months they were ready to deliver.”

"We used CIL standards since the company's inception. CIL standards stand up well against any and all competition.

“Since 2003, we have been using CIL’s research products. We are always entirely satisfied with the quality and quick delivery time. CIL provides us with all the necessary test data for our pharmacist to use when approving the product for our studies.”

“CIL has greatly facilitated our clinical research by supplying specially designed labeled compounds. We have made great progress in our neonatal antioxidant research program by the provision of labeled glutathione by CIL.”

“I have used metabolic substrates from Cambridge Isotope Labs for nutrition and exercise physiology studies for two decades. I have been very pleased with the quality of the products and service provided by CIL.”

“I have been a customer of Cambridge Isotope Laboratories for over 25 years and have been very satisfied with the quality of its products, such as D2O, isotopic labeled compounds, etc. I have also been very satisfied in my dealing with its staff and sales representatives. They are always very eager to help me and my colleagues in choosing the most appropriate materials at the most reasonable prices for our experiments. It has been a pleasure to work with CIL!”

“Several years ago CIL provided much-sought-after high-enrichment 17O-labeled water. This led to the development of very high-field 17O NMR spectroscopy of proteins. This greatly facilitated our research and has led to a number of recent publications that have pushed this field of research forward (e.g. Hu et al., 2005, JACS 127:11922; Chekmenev et al., 2006, BJ 91:3076).”

Tim Cross, PhD
National High Magnetic Field Laboratory
Florida State University
Tallahassee, FL

“Metabolism has an essential role in biological systems. Identification and quantitation of the compounds in the metabolome is defined as metabolomics or metabolic profiling, and it is applied to define metabolic changes related to genetic differences, environmental influences and disease or drug perturbations.”

Warwick B. Dunn, PhD
University of Birmingham
West Midland, UK

“I have been buying my supply of stable isotopes for metabolic research from Cambridge Isotope Labs since 2003. I like to buy my supplies from CIL because I can rely on a good price and prompt delivery. This service is made feasible by constant efforts of my representative, who keeps me well informed regarding availability issues and takes personal interest in making sure that I get it on time. On one occasion I ran out of materials unexpectedly and CIL accommodated my requirements so that experiments could be completed. I will continue to buy from CIL since I always know I will receive the best service, product quality and competitive prices.”

Meena Garg, PhD
Professor of Pediatrics
Pediatrics, Mattel Children's Hospital UCLA
Los Angeles, CA

“Since starting our clinical brain metabolism studies with CIL products in 2003, we have enjoyed an outstanding relationship with your company. The diversity and availability of 13C-labeled isotopes has been crucial for our research progress and subsequent funding from the National Institutes of Health. In addition to the high quality of your products, I have been very impressed with your and the company’s customer service. Your frequent visits to UCLA, the rapid response time to quote requests, and the feedback from CIL regarding shipping dates is much appreciated. I look forward to a long and productive relationship with you and Cambridge Isotope Labs."

Thomas C. Glenn, PhD
Associate Adjunct Professor
Division of Neurosurgery
David Geffen School of Medicine at UCLA

“We use CIL because, in addition to their labeled media, they carry an extensive line of reagents for biomolecular NMR, such as buffers, detergents and reducing agents. They have also been quite helpful by adding new products in response to customer needs.”

Christopher Lepre, PhD
Research Fellow II, Structural Biology
Vertex Pharmaceuticals, Inc.
Cambridge, MA

“CIL has solved many of our technical problems and custom made many isotopes supporting the advancement of stable isotope research in the metabolic field. Over the past 27 years, CIL has provided safe and reliable research products. CIL’s research products utilized in stable isotope-tracer techniques have played an important role in the fields of diabetes, obesity, exercise and AIDS research. In addition, CIL products were also extensively used in our long time investigation of amino acid requirements in health and diseased condition led by Dr. Vernon R.Young, which has led to global improvement of health. CIL also provides excellent customer services. The staffs are knowledgeable and are enthusiasm in discussing with the investigators and developing new products to serve the research communities. My 30-year collaboration with CIL has been a pleasant and productive experience. I would like to say thank you for the many years of research support you have provided.”

Dr. Yong-Ming Yu
Shriner's Hospitals for Children's - Boston
Surgical Research
Boston, MA

“CIL has been a strong supporter of NMR methods development over the years, providing critical isotope-enriched reagents for research and development, without which many of the recent advances in biomolecular NMR would simply not have been possible. In particular, the broad biological impact and tremendous success of multidimensional triple-resonance biomolecular NMR would not have been achieved without the high quality and broadly accessible reagents that CIL has provided to the scientific community over the last 20 years.”

Dr. Gaetano Montelione
Professor Molecular Biology and Biochemistry
Rutgers University Director of the Northeast
Structural Genomics Consortium

“The methodological development that NMR has been in the past six decades would not have been possible without close collaborations with companies that love to see progress happening. CIL is a particularly strong and supportive partner, and many ideas with respect to labelling pattern that looked crazy on the first sight became reality through CIL, enabling us to conquer new areas for NMR structure determination. There are a wide variety of examples where talking to CIL has pushed science forward.”

Prof. Dr. Hartmut Oschkinat
NMR-Supported Structural Biology
Forschungsinstitut fuer Molekulare
Pharmakologie (FMP)
Berlin, Germany

“We recently found a way of cell-free protein synthesis from PCR-amplified DNA that gives sufficient yield for subsequent analysis of the protein by NMR spectroscopy. So now we can go from gene to NMR spectrum, including site-directed mutations, in a day. We have tested it with ¹³C/¹⁵N-isoleucine from CIL and it worked perfectly. I barely recognize myself – never set my eyes on isotope labeled amino acids like this before.”

Dr. Gottfried Otting
Research School of Chemistry
Australian National University
Canberra, Australia

“Stable isotope labeling with amino acids in cell culture (SILAC) is a simple and straightforward approach for in vivo incorporation of a label into proteins for mass spectrometry (MS)-based quantitative proteomics. SILAC relies on metabolic incorporation of a given "light" (unlabeled) or "heavy" (labeled) form of the amino acid into the proteins. The method relies on the incorporation of amino acids with substituted stable isotopic nuclei (e.g. ¹³C, ¹⁵N). Thus in an experiment, two cell populations are grown in culture media that are identical except that one of them contains a “light” and the other a “heavy” form of a particular amino acid (e.g. ¹²C and ¹³C labeled L-Lysine, respectively). When the labeled analog of an amino acid is supplied to cells in culture instead of the natural amino acid, it is incorporated into all newly synthesized proteins. After a number of cell divisions, each instance of this particular amino acid will be replaced by its isotope-labeled analog. Since there is hardly any chemical difference between the labeled amino acid and the natural amino acid isotopes, the cells behave exactly like the control cell population grown in the presence of normal amino acid. It is efficient and reproducible as the incorporation of the isotope label is 100%. We anticipate that potential applications of SILAC will lead to its use as a routine technique in all areas of cell biology.”

Dr. Akhilesh Pandey
Johns Hopkins University

“Over the years, CIL has shown tremendous enthusiasm and expertise in working with researchers to develop the latest strategies in isotope labeling for bioNMR. They continue to do so. They have also been excellent in helping graduate students, post-docs and beginning investigators get started.”

Dr. Jeffrey Peng
Assistant Professor, Department of Chemistry and Biochemistry
University of Notre Dame
Notre Dame, Indiana

“My research group develops solid-state NMR methods for protein structure determination, requiring large quantities of ¹³C, ¹⁵N-labeled samples produced in-house. We have been very pleased with CIL products for isotopically labeled protein expression, including glucose, glycerol, ammonium chloride, BioExpress^® and specifically labeled amino acids. Using CIL products, we routinely obtain several milligrams of labeled membrane proteins per liter of E. coli and ten to hundreds of milligrams of water-soluble proteins. We especially appreciate the competitive pricing, outstanding quality control, friendly customer service and timely delivery of a wide range of in-stock products that CIL provides. At a time when many other vendors cut corners to earn business, it’s reassuring to know that CIL values its customers and never compromises product quality.”

Dr. Chad Rienstra
Chemistry Department
University of Illinois
Urbana, IL

“The heavy-labeled mouse tissue from CIL was extremely useful to validate labeled tissue produced in our own laboratory. We isolated peptides from the CIL tissue and ran our own independent analysis on a mass spectrometer. Based on these analyses we were confident to move forward with our proteomics experiments.”

Jesse Rinehart, PhD
Assistant Professor
Yale University School of Medicine
Department of Cellular & Molecular Physiology
Systems Biology Institute

“We are very pleased with the quality of CIL’s BioExpress^® 6000 media. The mammalian cell growth media from CIL provides an excellent opportunity to obtain isotope-labeled samples of eukaryotic proteins for NMR studies. When comparing CIL’s BioExpress^® 6000 media with typical rich growth media no differences in growth or expression rates were found.”

Prof. Dr. Harald Schwalbe
Institut fur Organische Chemie
Johann Wolfgang Goethe-Universitat
Max-von-Laue-Strasse 7
D-60438 Frankfurt, Germany

“Cambridge Isotope Laboratories has been our preferred supplier of stable isotopes for more than 15 years and has provided us with quality products and dedicated service.”

Dr. L.J.C. van Loon
Associate Professor - Stable Isotope Research Laboratory
Department of Movement Sciences
Department of Human Biology
Academic Hospital Maastricht and Maastricht University
The Netherlands

“We have enjoyed a close working relationship with CIL for the last 15 years, both as a customer and a collaborator. We’ve had great interactions with sales, with the management and the chemists; from top to bottom CIL is a great company that you can really work with in this specialized area. We’ve been able to do science that we couldn’t have done without working with CIL.”

Professor James R. Williamson
The Skaggs Institute for Chemical Biology
The Scripps Research Institute

“For the past decade CIL have consistently provided deuterated reagents and service of the highest quality to support our development needs. We look forward to continuing to work with CIL as we further advance our product pipeline.”

“For the past decade CIL have consistently provided deuterated reagents and service of the highest quality to support our development needs. We look forward to continuing to work with CIL as we further advance our product pipeline.”