SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by which ADAM12s Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase1

Duan, Q.; Li, D.; Xiong, L.; et al.

Small cell lung cancer (SCLC) is an aggressive type of lung cancer. Due to the poor survival rate of SCLC patients, efforts to better understand the mechanisms underlying tumorigenesis and metastasis are sought. Utilizing a SILAC-based quantitative proteomic workflow, Xu and colleagues assessed the molecular mechanisms of SCLC metastasis by investigating the highly expressed ADAM12S protein in SCLC cells. In combining experimental and bioinformatic results, this discovery work revealed the correlation of ADAM12S to glycolysis and metabolic reprogramming. In addition to furthering our understanding of the oncogenic functions of ADAM12S, this study helps pave next steps in identifying a therapeutic intervention for SCLC.