Metabolomics and Isotope Tracing

Jang, C.; Chen, L.; Rabinowitz, J.D.

Metabolomics and metabolism are two increasingly employed research endeavors. Given the advancements and the complimentary nature of these fields, Rabinowitz and colleagues herein review the analytical workflow (from sample handling to data analysis/interpretation) and best practices for both measuring/quantifying metabolites (in metabolomics) and tracing stable isotope labeling (in metabolism). Highlighted are four types of biological applications, with an eye into future metabolic research directions.