Essential Amino Acid-enriched Meal Replacement Promotes Superior Net Protein Balance in Older, Overweight Adults

Coker, R.H.; Shin, K.; Scholten, K.; et al.

To help reduce muscle atrophy and sarcopenia in older adults, Coker et al. developed an essential amino acid-enriched meal replacement (EMR). This advanced nutritional product is compositionally distinct from other market available meal replacements, with its efficacy tested in a comparative, whole-body protein kinetics study. Using stable isotope tracer methodology and time-course LC-ESI-MS analysis of plasma samples, the EMR formulation promoted more than 2-fold increments in whole body net protein balance compared to a high protein meal replacement. This EMR approach may represent a valuable lifestyle intervention in preserving lean tissue mass and promoting weight loss in older, overweight adults.

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