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The Standard - December 2021

New Nitrosamines Mixes – US EPA Method 521 and More!

Since the initial reports of nitrosamine contamination in blood pressure medicines in 2018, screening lists have become more commonplace for nitrosamine levels in medications and other matrices. CIL has offered stable isotope-labeled and native individual nitrosamine standards for many years and has recently developed multi-component mixtures to support comprehensive testing.

Included in these new releases are mixtures that can be used with United States Environmental Protection Agency (US EPA) Method 521, which is a method that provides procedures for the determination of several nitrosamines in drinking water by GC-MS/MS analysis. In addition, CIL has prepared a pair of mixtures which include the same target list of nitrosamines as the Method 521 standards but with the addition of N-nitrosomorpholine, which can be especially useful when testing food, pharmaceutical, and tobacco samples.

To learn more about CIL’s full line of nitrosamine standard solutions, please click here to access and download our Nitrosamines Spotlight.

Featured Products

Catalog No. Description Amount
ES-5652 Method 521 Nitrosamine Surrogate Mixture 1.2 mL in methylene chloride-D2
ES-5653 Method 521 Nitrosamine Analyte PDS Mixture 1.2 mL in methylene chloride
ES-5650 Deuterated Nitrosamines Standard Mixture 5 mL in methylene chloride-D2
ES-5651 Nitrosamines Native Standard Mixture 5 mL in methylene chloride


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stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.