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IsoTopics™ - May 2022

Fructose Reprograms Glutamine-Dependent Oxidative Metabolism to Support LPS-Induced Inflammation

Jones, N.; Blagih, L.; Zani, F.; et al.

Fructose consumption has been demonstrated to exacerbate various non-communicable disorders; however, its metabolic and mechanistic impact on immune cells is not well established. This article examined how human monocytes and mouse macrophages respond metabolically and functionally to fructose exposure.  Among the experiments performed was MS-based metabolic analysis of cells cultured with stable isotope tracers (e.g., U-13C6 D-glucose, U-13C6 D-fructose). Overall, the works results have pathophysiological significance by showing, for the first time, that fructose promotes an inflammatory phenotype in both human and mouse mononuclear phagocytes.

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