IsoTopics™ - May 2022
Alzheimer’s disease (AD) continues to be one of the more widespread neurodegenerative diseases, yet its pathogenesis remains unclear. A causative factor is believed to attribute from the accumulation of amyloid-β (Aβ) peptides in the brain.
read moreColorectal cancer (CRC) is one of the most common causes of cancer mortality worldwide. To gain a better understanding of CRC progression, organ-on-chip models that emulate in vivo physiology have been designed.
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Fructose consumption has been demonstrated to exacerbate various non-communicable disorders; however, its metabolic and mechanistic impact on immune cells is not well established.
read moreGlycosylation is a prevalent co-/post-translation modification in biological systems that putatively links to cancer and neurodegenerative diseases. Efforts to unravel this relationship and understand glycan structure/function have been forged but have been hampered by methodological and analytical challenges.
read moreStable isotope tracer approaches are commonly employed in metabolic research to help better understand cellular processes and the impact metabolism has on health and disease.
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- Temporal Quantitative Profiling of Newly Synthesized Proteins during Aß Accumulation
- Human Colorectal Cancer-on-Chip Model to Study the Microenvironmental Influence on Early Metastatic Spread
- Fructose Reprograms Glutamine-Dependent Oxidative Metabolism to Support LPS-Induced Inflammation
- Utilizing Liquid Chromatography, Ion Mobility Spectrometry, And Mass Spectrometry to Assess INLIGHT™ Derivatized N-Linked Glycans in Biological Samples
- A Mass Spectrometry-Based Targeted Assay for Detection of SARS-Cov-2 Antigen from Clinical Specimens
- Reference Materials for MS-Based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC)
- Principles of Stable Isotope Research – with Special Reference to Protein Metabolism
