As of June 12, 2018 our Privacy Policy has been updated. For individuals in the European Union, CIL uses cookies on this website. Please review the new privacy statement to see how. By continuing to use this website you agree to us using cookies in accordance with our privacy statement. Click here for the new privacy statement..OK

Corporate Overview

IsoTopics™ - May 2019

Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

Yao, C.H.; Wang, R.; Wang, Y.; et al.
 
In an effort to better understand the Warburg effect (or aerobic glycolysis) in relation to the metabolic requirements of cell proliferation, Yao et al. applied a model where proliferation could be turned on and off. Using stable isotopes and metabolomic techniques, they then quantified the metabolic changes in various cell types as a function of cell division. The authors show that the cancer cells they examined consume more oxygen during proliferation to sustain their mitochondria. Contrary to the common assumption that proliferating cells increase glycolysis at the expense of mitochondrial metabolism, their results show that glycolysis and mitochondrial respiration increase by equal amounts during proliferation. The findings may help design improved tests and targeted treatments for these tumors.
 
Read article

 






Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.