As of June 12, 2018 our Privacy Policy has been updated. For individuals in the European Union, CIL uses cookies on this website. Please review the new privacy statement to see how. By continuing to use this website you agree to us using cookies in accordance with our privacy statement. Click here for the new privacy statement..OK

Corporate Overview

IsoTopics™ – October 2019

SILAC quantitative proteomics and biochemical analyses reveal a novel molecular mechanism by which ADAM12S promotes the proliferation, migration, and invasion of small cell lung cancer cells through upregulating hexokinase 1

Duan, Q.; Li, D.; Xiong, L.; et al.

Small cell lung cancer (SCLC) is an aggressive type of lung cancer. Due to the poor survival rate of SCLC patients, efforts to better understand the mechanisms underlying tumorigenesis and metastasis are sought. Utilizing a SILAC-based quantitative proteomic workflow, Xu and colleagues assessed the molecular mechanisms of SCLC metastasis by investigating the highly expressed ADAM12S protein in SCLC cells. In combining experimental and bioinformatic results, this discovery work revealed the correlation of ADAM12S to glycolysis and metabolic reprogramming. In addition to furthering our understanding of the oncogenic functions of ADAM12S, this study helps pave next steps in identifying a therapeutic intervention for SCLC.

Read article 


Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.