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Corporate Overview

IsoTopics™ – October 2019



SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase

Duan, Q.; Li, D.; Xiong, L.; et al.

Small cell lung cancer (SCLC) is an aggressive type of lung cancer.  Due to the poor survival rate of SCLC patients, efforts to better understand the mechanisms underlying tumorigenesis and metastasis are sought. 

 

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Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics

Galvez, L.; Rusz, M.; Schwaiger-Haber, M.; et al.

Oxaliplatin is a chemotherapy drug administered to aid treatment of metastatic colorectal cancer. Despite its regularity, the impact of this metallodrug on drug uptake/distribution and the metabolome remains unclear. 

 

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Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men

Holwerda, A.M.; Paulussen, K.J.M.; Overkamp, M.; et al.

Anabolic resistance is considered to play a key role in the progression of sarcopenia in older adults. Resistance exercise potently increases muscle protein synthesis, with post-exercise recovery further enhanced by the ingestion of >40 g of protein. Since older individuals may not be able to ingest such large doses of protein, van Loon and colleagues investigated the effect of co-ingesting 15 g of protein with or without added leucine.

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Assessment of methylcitrate and methylcitrate to citrate ratio in dried blood spots as biomarkers for inborn errors of propionate metabolism

Al-Dirbashi, O.Y.; Alfadhel, M.; Al-Thihli, K.; et al.

Propionyl-CoA metabolic defects require early diagnosis in neonates to limit life-threatening complications. Regrettably, a specific marker for the prognosis/monitoring of propionic acidemia (PA) has yet to be proposed. Al-Dirbashi et al. therefore aimed to evaluate the potential of methylcitric acid (MCA) and its ratio to citric acid (CA) as markers of propionate metabolism disorders. The method quantified CA and MCA derivatives in patient DBS samples by RPLC-MRM/MS, with D4 CA and D3 MCA functioning as internal standards. Although further studies with larger patient cohorts are required, the novel results demonstrate that MCA and MCA/CA can serve as a potential biomarker for both PA and methylmalonic acidemia.

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Metabolomics and Isotope Tracing

Jang, C.; Chen, L.; Rabinowitz, J.D.

Metabolomics and metabolism are two increasingly employed research endeavors. Given the advancements and the complimentary nature of these fields, Rabinowitz and colleagues herein review the analytical workflow (from sample handling to data analysis/interpretation) and best practices for both measuring/quantifying metabolites (in metabolomics) and tracing stable isotope labeling (in metabolism). Highlighted are four types of biological applications, with an eye into future metabolic research directions.

 
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