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IsoTopics™ – October 2017

Now that fall is here, we look forward to cooler weather and sharing the latest MS developments with you. In case you missed any over the past few months, here are several articles featuring novel approaches we think you will enjoy.
More and more we are hearing from the community about a need for standardization among labs. At ASMS in June, we officially launched a myriad of new products that focus on quality control and standardization. We hope these innovative products will be beneficial to your workflow as well as for the entire community. If you have any questions, we will be happy to answer them.
So grab a pumpkin spice latte and enjoy this latest edition of IsoTopics! 
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HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification
Ma, Y.; McClatchy, D.B.; Barkallah, S.; et al.
The non-canonical amino acid azidohomoalanine (AHA) has proven effective at measuring the synthesis and turnover of newly synthesized proteins (NSPs) in various biological samples, such as mouse tissue. 
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Multiplexed MRM-Based Protein Quantitation Using Two Different Stable Isotope-Labeled Peptide Isotopologues for Calibration
LeBlanc, A.; Michaud, S.A.; Percy, A.J.; et al.
Toward enhanced depth and precision/accuracy of multiplexed protein quantitation, LeBlanc et al. developed a new calibration approach utilizing two variations of stable isotope-labeled tryptic peptides (referred to as SIS 1 and SIS 2). The SIS 1 peptides have a C-terminal 13C/15N-label, while SIS 2 has an internal 13C/15N-labeled residue in addition to a C-terminal label. 
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Anion-Exchange Chromatography Coupled to High Resolution Mass Spectrometry: a Powerful Tool for Merging Targeted and Non-Targeted Metabolomics
Schwaiger, M.; Rampler, E.; Hermann, G.; et al.
To help overcome the analytical challenges of ion-pairing-MS and GC-MS, Schwaiger et al. developed an innovative analytical workflow involving fast-scale anion-exchange chromatography and high resolution MS for simultaneous targeted/non-targeted metabolomic analysis.
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Metabolite Spectral Accuracy on Orbitraps
Su, X.; Lu, W.; Rabinowitz, J.D.
Spectral accuracy is an important metric of mass spectrometer performance, reflecting the ability to accurately quantify labeled forms. Rabinowitz et al. identify potential systematic errors in spectral accuracy that occur in high resolution Orbitrap measurements. 
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How Close Are We to Complete Annotation of Metabolomes?
Viant, M.R.; Kurland, I.J.; Jones, M.R.; Dunn, W.B.
Efforts to identify and annotate an organism's metabolome are continuing through untargeted, one-dimensional and multidimensional, MS-based methodologies.
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Plasmonic Silver Nanoshells for Drug and Metabolite Detection
Huang, L.; Wan, J.; Wei, X.; Liu, Y.; et al.
Given the demand for improved analytical methods for biomedical applications, Qian et al. developed plasmonic silver nanoshells for metabolite detection in clinical in vitro diagnostics. 
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