As of June 12, 2018 our Privacy Policy has been updated. For individuals in the European Union, CIL uses cookies on this website. Please review the new privacy statement to see how. By continuing to use this website you agree to us using cookies in accordance with our privacy statement. Click here for the new privacy statement..OK

Corporate Overview

IsoTopics™ – November 2022

An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field

Porro, B.; Eligini, S.; Conte, E.; et al.

The impact of coronary artery disease (CAD) on the arginine/nitric oxide (Arg/NO) pathway continues to be investigated. To strengthen the field’s understanding, Banfi and colleagues developed a targeted MS metabolomics method to quantify Arg/NO pathway metabolites in human plasma. The method used a collection of stable isotope-labeled standards (e.g., 13C7/15N4 L-homoarginine, D6 ornithine), was validated against FDA guidelines, and applied to patient samples of different grades/types of CAD. Although larger study cohorts are needed, findings of significance demonstrate sex-dependent correlations in Arg/NO metabolites on acute cardiovascular events.  

Read article


Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.