Cancer Cell Metabolism Unique Features Inform New Therapeutic Opportunities
Due to the complexity of the biochemical processes involved in cancer progression, research in the area of cancer metabolism requires a multidisciplinary approach. This briefing reviews key findings of six leading cancer cell metabolism researchers who have used techniques in genomics, metabolomics, and metabonomics to study biochemical processes, including oncogenic cell signaling and metabolic pathways using stable isotopes. As a result of this work, several new cancer therapies are currently undergoing clinical trials.
Presented by Hot Topics in Life Sciences
Reported by Paul Riccio | Posted August 14, 2015
Citation: The New York Academy of Sciences. Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. Academy eBriefings. 2015. Available at: www.nyas.org/TumorMetabolism-eB
Overview:
Cancer cells become lethal when they form large tumors, metastasize, and colonize diverse tissue types. These functions depend on different metabolic pathways from those active in non-transformed cells. Rapidly growing and proliferating cells require constant biosynthesis, in addition to energy in the form of ATP that all cells need for normal functions. The glucose and glutamine that are exclusively catabolized to water and carbon dioxide in quiescent cells are partly diverted to macromolecule production in dividing cells. Cell metabolism has long been a focus of molecular biology; for the cancer field its study represents a return to original lines of inquiry after years of focus on the genetics of cell transformation and the oncogenes involved in signal transduction pathways. At the May 28, 2015, Hot Topics in Life Sciences symposium Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities, the speakers expressed hope that a synthesis of these two approaches will yield progress in cancer research.
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