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Corporate Overview

IsoTopics™ – November 2015

Dear Researcher:
We are delighted to present the first edition of CIL's mass spectrometry newsletter, IsoTopics™.
This newsletter will highlight publications, researchers, and applications utilizing stable isotopes in mass spectrometry focusing on metabolomics, proteomics, and the clinical research fields. 
Over the past few years, advancements in sensitivity, selectivity, and throughput of mass spectrometers has assisted in the identification of potential biomarkers, improvements in clinical testing, and an overall better understanding of human health and disease. Stable isotopes have further enhanced this effort and have played a key role for both quantification and qualification in numerous applications. 
We hope that you find this newsletter a valuable and informative resource. Our goal is to share the utility of CIL products across various scientific fields to increase information exchange and further technological advancements utilizing mass spectrometry and stable isotopes.
For over 30 years our business has been stable isotopes, but our focus has always been you, our valued customers. We want to thank you for your loyalty and feedback throughout the years, and we look forward to partnering with you on future research projects. Our mission will continue to be providing high-quality stable isotope-labeled products and unparalleled service.
Please feel free to contact us with any questions or requests to assist in your next project. 
Enjoy the very first edition of IsoTopics™, and we greatly look forward to your feedback.
All the best,
Krista Backiel
Director of Marketing
Metabolomics Product Manager 
Tasha Agreste
Proteomics Product Manager
Deuterated Reagents & Intermediates Product Manager
China Sales - Research Products
Ros Shelhamer
Business Development Manager
Metabolic, MRI/MRS, Clinical 
Kate Bennitt
Sales & Marketing Specialist

Relative Quantification and Higher-Order Model of Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

Investigations into the regulation of the N-linked glycome by cancer and disease demands rigorous quantitative methods afforded by stabie isotope labeling and identification given by the specificity of mass spectrometry. N-linked glycans present challenges to MS because of the complexity of their structures (MS/MS or MSn required), hydrophilicity, and low abundance. Learn more...

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A Standardized Kit for Automated Quantitative Assessment of Candidate Protein Biomarkers in Human Plasma

To assist in the standardization of multiple reaction monitoring-mass spectrometry (MRM-MS) for clinical proteomics, a biomarker assessment kit (BAK-76) has been developed for the precise quantitation of 76 high-to-moderate-abundance proteins, which spans a plasma concentration range of >4 orders of magnitude. 

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Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Metabolic isotopic analysis (MIA) utilizes stable isotope-enriched substrates and mass spectrometry to study metabolism in living cells and tissue. Because isotope-labeled substrates make the determination of metabolic pathways and flux in living cells or tissue possible, MIA has become an integrated platform in oncology research.

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A Roadmap for Interpreting 13C Metabolite Labeling Patterns from Cells

Looking to increase the data quality and output of your 13C tracer study? This paper reviews key aspects of experimental design and data interpretation when utilizing 13C labeled tracers to interrogate cellular metabolism. Topics include: a comparison of metabolic steady state and isotopic steady state, labeling patterns of metabolites and cellular compartments, and labeling for steady state and dynamic studies.  

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Cancer Cell Metabolism Unique Features Inform New Therapeutic Opportunities
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LC-MS-Based Quantification of Intact Proteins: Perspective for Clinical and Bioanalytical Applications

Mass spectrometry as a routine tool in the clinic is becoming more and more of a reality every day, presenting numerous opportunities in the field of proteomics. This review provides a comprehensive overview of existing LC-MS bottom-up proteomic techniques, as well as the potential for future approaches using intact protein quantification. It includes a comparison between the two approaches, the limitations of both, and some of the hurdles that will need to be overcome for successful detection.

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Seven Reasons to Buy from Cambridge Isotope Laboratories, Inc. (CIL)

by Don Chace


1. Proven in the field. CIL developed the first sets of internal standards for MS/MS quantification in the 1990s with the primary developers of the technology used in screening.  

2. CIL standards have been an essential component of NBS lab protocols and methods used to screen millions of infants.


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CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.