As of June 12, 2018 our Privacy Policy has been updated. For individuals in the European Union, CIL uses cookies on this website. Please review the new privacy statement to see how. By continuing to use this website you agree to us using cookies in accordance with our privacy statement. Click here for the new privacy statement..OK

Corporate Overview

IsoTopics™ – May 2020

TMTpro: Design, synthesis, and initial evaluation of a proline-based isobaric 16-plex tandem mass tag reagent set

Thompson, A.; Wölmer, N.; Koncarevic, S.; et al.

Isobaric tagging has become an established tool in quantitative mass spectrometry for an array of proteomic-driven applications. Given the demands for increased multiplexing, new isobaric peptide tagging reagents were developed. These reagents, termed TMTpro™, utilize 13C/15isobutylproline as reporters instead of the classical glycine-based tags used in alternate isobaric reagent sets, for increased multiplexing capacity. Demonstrated here is the synthesis and performance of the novel 16-plex TMTpro reagents for use in discovery and quantitative MS proteomics. These reagents provide high labeling efficiency and quantitative accuracy toward opportunities for expanded applications in MS ‘omics.

Read article

Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.