As of June 12, 2018 our Privacy Policy has been updated. For individuals in the European Union, CIL uses cookies on this website. Please review the new privacy statement to see how. By continuing to use this website you agree to us using cookies in accordance with our privacy statement. Click here for the new privacy statement..OK

Corporate Overview

IsoTopics™ – May 2020

Impact of enteral arginine supplementation on lysine metabolism in humans: A proof-of-concept for lysine-related inborn errors of metabolism

Schmidt, Z.; Murthy, G.; Ennis, M.; et al.

Standard treatments for inborn errors of metabolism affecting catabolic pathways of essential amino acids involve dietary restriction or modification with supplements. This is the case for pyridoxine dependent epilepsy (PDE) where Lys is restricted in the diet. Arginine has been suggested as a supplement, because it competes with Lys for transport across tissues. To investigate the impact of Arg supplements on Lys metabolism, a proof-of-concept study with healthy humans was performed. This involved an oral dosing strategy with unlabeled Arg·HCl and the tracer 1-13C L-Lys, being oxidized to 13CO2. While the isotope ratio MS results suggested, for the first time, a potential range of L-Arg·HCl for oral supplements, follow-up studies in PDE patients are required.

Read article

Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.