A Timeline of Stable Isotopes and Mass Spectrometry in the Life Sciences
Lehmann, W.
Here Wolf-Dieter Lehmann chronicles the development of stable isotopes (principally 13C, D, 15N, and 18O) and the MS-based techniques used for their analysis. The review is divided into time segments (1920-1950, 1950-1980, 1980-2000, and 2000-2010), with methods and applications discussed therein. Included in the highlights is the use of stable isotopes (as quantitative standards or metabolic tracers) with LC- or GC-MS to address questions in ‘omics (e.g., metabolomics, proteomics, and lipidomics), metabolism, and forensics, among other fields of application.
Articles
- Multiplexed Proteome Analysis with Neutron-Encoded Stable Isotope Labeling in Cells and Mice
- A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain
- Two Complementary Reversed-Phase Separations for Comprehensive Coverage of the Semipolar and Nonpolar Metabolome
- METLIN: A Technology Platform for Identifying Knowns and Unknowns
- Noninvasive Liquid Diet Delivery Of Stable Isotopes Into Mouse Models For Deep Metabolic Network Tracing
- A Timeline of Stable Isotopes and Mass Spectrometry in the Life Sciences
