Biochemical Pathways Affected by Mitochondrial Stress | Cambridge Isotope Laboratories, Inc.
In a landmark study, Mootha VK et al. integrated metabolomic, proteomic, and RNA profiling strategies to identify hypotheses of the biochemical pathways affected by mitochondrial stress. The results indicated a link between mitochondrial dysfunction and serine/homocysteine metabolism. Further examination of Ser biosynthesis and transsulfuration revealed mechanisms by which mitochondrial dysfunction might compromise one-carbon synthesis in mammalian cells.
Abstract
Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK.
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