IsoTopics™ – July 2016
Dear Researcher,
We are delighted to present the third edition of our newsletter, IsoTopicsTM! In this issue, we feature several articles by researchers that have further advanced proteomics, metabolomics, and clinical research. Some of these researchers have used traditional CIL products in new, exciting ways and some have used brand-new CIL products to solve a problem that may not have been possible in the past. We hope that these articles inspire further development in mass spec applications and collaboration among researchers from various disciplines.
Please enjoy our latest edition of IsoTopics and send any feedback our way!
Sincerely,
Your CIL Partners
Proteomics Product Manager
Deuterated Reagents & Intermediates Product Manager
China Sales - Research Products
Metabolic, MRI/MRS, Clinical
kateb@isotope.com
The zebrafish (Danio rerio) is an established model organism for studying cardiovascular disease. To better understand protein flux in the myocardium, Doherty MK et al. fed zebrafish low levels of L-Leu (d7), then measured its synthesis and turnover rates over an eight week labeling period.
read moreCapitalizing on the merits of neutron encoding (NeuCode), Coon J et al. applied this metabolic labeling technique to genetically engineered mice models to investigate mammalian biology in vivo.
read moreGiven the growing interest in algal biomass in biological and biofuel applications, Antoniewicz M et al. developed a new analytical method to more conveniently quantify carbohydrates in C. vulgaris.
read moreIn a landmark study, Mootha VK et al. integrated metabolomic, proteomic, and RNA profiling strategies to identify hypotheses of the biochemical pathways affected by mitochondrial stress. The results indicated a link between mitochondrial dysfunction and serine/homocysteine metabolism.
read moreThis review article provides a retrospective and prospective five-year view of quantifying human plasma proteins for biomarker development in a clinical setting.
read moreArticles
- Determining Synthesis Rates of Individual Proteins in Zebrafish Danio rerio with Low Levels of a Stable Isotope Labelled Amino Acid
- NeuCode Proteomics and Bap1 Regulation of Metabolism | Cambridge Isotope Laboratories, Inc.
- Stable-Isotope Labeling of Algal Biomass Carbohydrates | Cambridge Isotope Laboratories, Inc.
- Biochemical Pathways Affected by Mitochondrial Stress | Cambridge Isotope Laboratories, Inc.
- MS-based, Quantitative Plasma Proteomics | Cambridge Isotope Laboratories, Inc.
