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Corporate Overview

IsoTopics™ – July 2016

Dear Researcher,

We are delighted to present the third edition of our newsletter, IsoTopicsTM! In this issue, we feature several articles by researchers that have further advanced proteomics, metabolomics, and clinical research. Some of these researchers have used traditional CIL products in new, exciting ways and some have used brand-new CIL products to solve a problem that may not have been possible in the past. We hope that these articles inspire further development in mass spec applications and collaboration among researchers from various disciplines.

Please enjoy our latest edition of IsoTopics and send any feedback our way!


Your CIL Partners


Krista Backiel
Director of Marketing
Metabolomics Product Manager 
Tasha Agreste
Proteomics Product Manager
Deuterated Reagents & Intermediates Product Manager
China Sales - Research Products
Ros Shelhamer
Business Development Manager
Metabolic, MRI/MRS, Clinical 
Kate Bennitt
Sales & Marketing Specialist

Determining Synthesis Rates of Individual Proteins in Zebrafish Danio rerio with Low Levels of a Stable Isotope Labelled Amino Acid

The zebrafish (Danio rerio) is an established model organism for studying cardiovascular disease. To better understand protein flux in the myocardium, Doherty MK et al. fed zebrafish low levels of L-Leu (d7), then measured its synthesis and turnover rates over an eight week labeling period. 

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NeuCode Proteomics and Bap1 Regulation of Metabolism | Cambridge Isotope Laboratories, Inc.

Capitalizing on the merits of neutron encoding (NeuCode), Coon J et al. applied this metabolic labeling technique to genetically engineered mice models to investigate mammalian biology in vivo.  

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Stable-Isotope Labeling of Algal Biomass Carbohydrates | Cambridge Isotope Laboratories, Inc.

Given the growing interest in algal biomass in biological and biofuel applications, Antoniewicz M et al. developed a new analytical method to more conveniently quantify carbohydrates in C. vulgaris.  

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Biochemical Pathways Affected by Mitochondrial Stress | Cambridge Isotope Laboratories, Inc.

In a landmark study, Mootha VK et al. integrated metabolomic, proteomic, and RNA profiling strategies to identify hypotheses of the biochemical pathways affected by mitochondrial stress. The results indicated a link between mitochondrial dysfunction and serine/homocysteine metabolism.  

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MS-based, Quantitative Plasma Proteomics | Cambridge Isotope Laboratories, Inc.

This review article provides a retrospective and prospective five-year view of quantifying human plasma proteins for biomarker development in a clinical setting. 

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Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
CIL has been ready to help with the analytical standards critical to the task of defining and resolving any major environmental contamination problems.