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IsoTopics™ – December 2018

13C-Labeled Yeast as Internal Standard for LC-MS/MS and LC High Resolution MS Based Amino Acid Quantification in Human Plasma

Hermann, G.; Schwaiger, M.; Volejnik, P.; et al.

Isotopically labeled extracts can be powerful standards for analyte quantification in MS-based assays. Here, Hermann and colleagues evaluated the utility of an in vivo-produced metabolite yeast extract in the absolute quantification of 14 amino acids in human plasma (SRM 1950). The amino acid content of the U-13C yeast extract (ISO1) was determined using SRM 2389a. The calibrated ISO1 served as internal standards in the cross-platform validations and was found to deliver excellent accuracy without impact on other assay figures of merit.

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