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Corporate Overview

IsoTopics™ – April 2017


SWATH-based Proteomics Identified Carbonic Anhydrase 2 as a Potential Diagnosis Biomarker for Nasopharyngeal Carcinoma
Luo, Y.; Mok, T.S.; Lin, X.; et al.
Given the prevalence of nasopharyngeal carcinoma (NPC) in Asian populations, there is an increasing need for diagnostic protein biomarkers. 
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Serotonin Biosynthesis as a Predictive Marker of Serotonin Pharmacodynamics and Disease-Induced Dysregulation
Welford, R.W.; Vercauteren, M.; Trébaul, A., et al.
In a metabolomics-based tracer study, Welford and colleagues used 13C-labeled tryptophan as an oral tracer to measure/quantify the biosynthesis and metabolism of serotonin in rats. Here, the flux and pharmacokinetics of serotonin pathway metabolites were measured in various tissues by LC-MRM/MS. The pharmacodynamic effects of serotonin synthesis inhibition in vivo were also investigated. 
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Comparative Analysis of INLIGHT™-labeled Enzymatically Depolymerized Heparin by Reverse-phase Chromatography and High-performance Mass Spectrometry

Mangrum, J.B.; Mehta, A.Y.; Alabbas, A.B., et al.

In an effort to overcome the analytical and technical challenges associated with glycosaminoglycan (GAG) analysis, Mangrum and colleagues applied the INLIGHT™ (individuality normalization when labeling with glycan hydrazide tags) labeling strategy to characterize and quantitatively analyze heparin digests (digHep).
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13C Metabolic Flux Analysis of Acetate Conversion to Lipids by Yarrowia lipolytica

Liu, N.; Qiao, K.; Stephanopoulos, G.

To better understand the metabolism of yeast Yarrowia lipolyticain the presence of volatile fatty acids, Stephanopoulos and colleagues performed a stationary 13C metabolic flux analysis using two isotopically labeled acetate tracers (13C1 and 13C2) as the feedstock.
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Historical and Contemporary Stable Isotope Tracer Approaches to Studying Mammalian Protein Metabolism
Wilkinson, D.J.
A formative article by Daniel Wilkinson of the University of Nottingham provided a historical perspective on the evolution of stable isotope tracers in relation to MS-based technological advancements. The impetus of the highlighted studies was to investigate in vivo mammalian metabolism (e.g., protein, lipid), either at a whole body or analyte-specific level.
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Stable Isotope Newsletters | Cambridge Isotope Laboratories
stable isotope, stable isotope labeled compounds, environmental contaminant standards
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