Stable Isotope Newsletters | Cambridge Isotope Laboratories

The Standard - July 2023
Dechlorane Plus, UV-328, and Methoxychlor Face Global Ban Under Stockholm Convention US EPA Proposes Rule to Reduce Emissions from Chemical Plants PCNs in Environmental and Human Exposure Studies CIL’s PAH Standards – For Food, Environmental, and Human Exposure Analysis
The Standard - April 2023
New Regulations in North America and Europe Increase Restrictions on More PFAS Compounds Flame Retardants – Legacy and New Use Compounds Pharmaceutical and Personal Care Products France Ends Exemption Use of Neonicotinoids
The Standard - December 2022
US EPA Withdraws Interim Registration Review Decision for Glyphosate CIL – The World’s Leading Producer of Stable Isotopes PFAS Detected in Pet Food Packaging
IsoTopics™ – November 2022
Cardiac Myosin Filaments are Maintained by Stochastic Protein Replacement An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field Continuous Oral Stable Isotope Ingestion to Measure Whole-Body Protein Turnover The Metabolism of Human Soluble Amyloid Precursor Protein Isoforms Is Quantifiable by a Stable Isotope Labeling-Tandem Mass Spectrometry Method TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies Isotope Tracing in Health and Disease
The Standard - October 2022
Dawn Mantz Joins the CIL Environmental Sales Team! US EPA Plans to Enforce Restrictions on Atrazine Use US FDA Limits Certain Phthalates in Food Packaging Materials Update on Halogenated Compounds from EURL
The Standard - July 2022
New 13C12-6PPD-Quinone Standard for Enhanced Analysis Ethylene Oxide and 2-Chloroethanol in Food Potassium Bromate Additive – Potential Carcinogen in Packaged Baked Goods FDA to Evaluate and Reconsider Bisphenol A Restrictions in Food Packaging US EPA Proposes Ban on Diuron on Food
IsoTopics™ - May 2022
Temporal Quantitative Profiling of Newly Synthesized Proteins during Aß Accumulation Human Colorectal Cancer-on-Chip Model to Study the Microenvironmental Influence on Early Metastatic Spread Fructose Reprograms Glutamine-Dependent Oxidative Metabolism to Support LPS-Induced Inflammation Utilizing Liquid Chromatography, Ion Mobility Spectrometry, And Mass Spectrometry to Assess INLIGHT™ Derivatized N-Linked Glycans in Biological Samples A Mass Spectrometry-Based Targeted Assay for Detection of SARS-Cov-2 Antigen from Clinical Specimens Reference Materials for MS-Based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) Principles of Stable Isotope Research – with Special Reference to Protein Metabolism
The Standard - April 2022
New Pyrethroid Metabolite Standards – Now Available! Europe Proposes Large Reduction in Use of Bisphenol A UK Approves Emergency Use Authorization of Thiamethoxam in Sugar Beets
The Standard - December 2021
Neonicotinoids of Particular Concern and Results from the 2019 European Union Report on Pesticide Residues in Food New Nitrosamines Mixes – US EPA Method 521 and More! ‘Isotope’ – It May be Our Middle Name, but it is not Our Only Business
The Standard - October 2021
Cannabis Testing Standards – Now Available from CIL! Foodomics – Standards for Metabolic Biomolecules and Food Contaminants Ethylene Oxide and 2-Chloroethanol Analytical Standards US EPA Method 1628 – New Method Posted for the Analysis of 209 PCB Congeners
The Standard – June 2021
Biomonitoring – Analytical Standards for Human Exposure Analysis Dioxin/Furan Mixtures for Food/Feed and GC-MS/MS Analysis Nitrosamine Standards Update – NPIP, NDBA, and NMEA Now Available! New Product Release – Glufosinate Chlorpyrifos Regulation Update
IsoTopics™ – May 2020
TMTpro: Design, synthesis, and initial evaluation of a proline-based isobaric 16-plex tandem mass tag reagent set Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown Impact of enteral arginine supplementation on lysine metabolism in humans: A proof-of-concept for lysine-related inborn errors of metabolism Identification of bioactive metabolites using activity metabolomics
The Standard – October 2019
BPS Joins BPA Ban in Thermal Paper Human Biomonitoring Initiative Takes Flight in Europe Halogenated Flame Retardant Ban in EU Update on Nitrosamine Standards – NMBA Now Available
IsoTopics™ – October 2019
SILAC quantitative proteomics and biochemical analyses reveal a novel molecular mechanism by which ADAM12S promotes the proliferation, migration, and invasion of small cell lung cancer cells through upregulating hexokinase 1 Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men Assessment of methylcitrate and methylcitrate to citrate ratio in dried blood spots as biomarkers for inborn errors of propionate metabolism Metabolomics and isotope tracing
The Standard - August 2019
Regulatory Actions by the EU and US EPA on Neonicotinoids Take Effect Analyzing Cyanotoxins in Surface Water and Drinking Water Proposed Limit on Perchlorate in Drinking Water
IsoTopics™ - May 2019
Assessment of NAD+ metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation Essential amino acid-enriched meal replacement promotes superior net protein balance in older, overweight adults Traceability to a primary reference measurement procedure (ID-LCMS): a key step in validating the clinical accuracy and safety of hospital blood glucose monitoring systems NMR and MS-based stable isotope-resolved metabolomics and applications in cancer metabolism
The Standard – April 2019
Move to Restrict Siloxanes in the European Union Blood Pressure Medicine Recalls Expanded Due to Presence of Nitrosamines Environmental Group Updates
The Standard – December 2018
Hervé Mohr Joins the CIL Environmental, Food, Water, and Exposure Analysis Standards Team! New Developments with Exposomics Initiatives Blood Pressure Medications Recalled Due to the Presence of Nitrosamines Chlorpyrifos Banned by EPA via Court Order
IsoTopics™ – December 2018
Lysine Propionylation Boosts Proteome Sequence Coverage and Enables a “Silent SILAC” Labeling Strategy for Relative Protein Quantification 13C-Labeled Yeast as Internal Standard for LC-MS/MS and LC High Resolution MS Based Amino Acid Quantification in Human Plasma Glutamine-Derived 2-Hydroxyglutarate Is Associated with Disease Progression in Plasma Cell Malignancies Hepatic Ketogenic Insufficiency Reprograms Hepatic Glycogen Metabolism and the Lipidome A Targeted Metabolomics Approach for Clinical Diagnosis of Inborn Errors of Metabolism A Guide to 13C Metabolic Flux Analysis for the Cancer Biologist SNMMI Image of the Year Is the Endocyte 177 Lu PSMA-617?
The Standard – August 2018
Chlorate Standards for Food and Water Testing Analyzing Cyanotoxins Using LC-MS/MS with 15N-Stable Isotope-Labeled Internal Standards Dicamba and Metabolites Per- and Polyfluoroalkyl Substances (PFAS) Update Phthalates and Phthalate Replacement Products
IsoTopics™ – May 2018
Multiplexed Proteome Analysis with Neutron-Encoded Stable Isotope Labeling in Cells and Mice A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain Two Complementary Reversed-Phase Separations for Comprehensive Coverage of the Semipolar and Nonpolar Metabolome METLIN: A Technology Platform for Identifying Knowns and Unknowns Noninvasive Liquid Diet Delivery Of Stable Isotopes Into Mouse Models For Deep Metabolic Network Tracing A Timeline of Stable Isotopes and Mass Spectrometry in the Life Sciences
IsoTopics™ – October 2017
HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification Multiplexed MRM-Based Protein Quantitation Using Two Different Stable Isotope-Labeled Peptide Isotopologues for Calibration Anion-Exchange Chromatography Coupled to High Resolution Mass Spectrometry: a Powerful Tool for Merging Targeted and Non-Targeted Metabolomics Metabolite Spectral Accuracy on Orbitraps How Close Are We to Complete Annotation of Metabolomes? Plasmonic Silver Nanoshells for Drug and Metabolite Detection
The Standard – April 2017
New Catalog Announcement New Pyrethroids Available at CIL CIL and Italy...A Relationship that Began 40 Years Ago Chlorpyrifos Under Review
IsoTopics™ – April 2017
SWATH-based Proteomics Identified Carbonic Anhydrase 2 as a Potential Diagnosis Biomarker for Nasopharyngeal Carcinoma Serotonin Biosynthesis as a Predictive Marker of Serotonin Pharmacodynamics and Disease-Induced Dysregulation Comparative Analysis of INLIGHT™-labeled Enzymatically Depolymerized Heparin by Reverse-phase Chromatography and High-performance Mass Spectrometry 13C Metabolic Flux Analysis of Acetate Conversion to Lipids by Yarrowia lipolytica Historical and Contemporary Stable Isotope Tracer Approaches to Studying Mammalian Protein Metabolism
IsoTopics™ – November 2016
Multiplexed MRM-based assays for the quantitation of proteins in mouse plasma and heart tissue. Optimal Tracers for Parallel Labeling Experiments and 13C Metabolic Flux Analysis: A New Precision and Synergy Scoring System N-linked Glycosite Profiling and Use of Skyline as a Platform for Characterization and Relative Quantification of Glycans in Differentiating Xylem of Populus Trichocarpa Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics Quality Management in Clinical Application of Mass Spectrometry Measurement Systems
The Standard – August 2016
1,2,3-Trichloropropane (1,2,3-TCP) in Drinking Water Acaricides in Common Flea and Tick Repellants Glyphosate Use and Regulations New POPs Chemicals Added to the Stockholm Convention in 2015
IsoTopics™ – July 2016
Determining Synthesis Rates of Individual Proteins in Zebrafish Danio rerio with Low Levels of a Stable Isotope Labelled Amino Acid NeuCode Proteomics and Bap1 Regulation of Metabolism \| Cambridge Isotope Laboratories, Inc. Stable-Isotope Labeling of Algal Biomass Carbohydrates \| Cambridge Isotope Laboratories, Inc. Biochemical Pathways Affected by Mitochondrial Stress \| Cambridge Isotope Laboratories, Inc. MS-based, Quantitative Plasma Proteomics \| Cambridge Isotope Laboratories, Inc.
The Standard – April 2016
Neonicotinoid Pesticides Parabens Introducing CIL's New Catalog, Standards for Environmental, Food, Water, and Exposure Analysis 2016 International Interlaboratory Study on Fish Reference Materials
IsoTopics™ – April 2016
Immobilized Metal Affinity Chromatography Coupled to Multiple Reaction Monitoring Enables Reproducible Quantification of Phospho-signaling Discovery of Serum Protein Biomarkers in the mdx Mouse Model and Cross-Species Comparison to Duchenne Muscular Dystrophy Patients Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Gluconeogenesis and Glycogenolysis Measurement Review Recommendations for Peptides Used In Mass Spectrometry Assays Proteomic Maps of Breast Cancer Subtypes
IsoTopics™ – November 2015
Relative Quantification and Higher-Order Model of Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples A Standardized Kit for Automated Quantitative Assessment of Candidate Protein Biomarkers in Human Plasma Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. A Roadmap for Interpreting 13C Metabolite Labeling Patterns from Cells Cancer Cell Metabolism Unique Features Inform New Therapeutic Opportunities LC-MS-Based Quantification of Intact Proteins: Perspective for Clinical and Bioanalytical Applications Seven Reasons to Buy from Cambridge Isotope Laboratories, Inc. (CIL)
The Standard – October 2015
Curious (but correct!) Naming of CIL's Isotopically Labeled Ethynylestradiol (EE2) Standard New PCN Standard (PCN Update) The Isotope Gateway
The Standard – July 2015
Sodium Monofluoroacetate Fipronil New Polychlorinated Naphthalenes (PCNs) CIL Isotope Separations, LLC (CIS)
The Standard – January 2015
Tobacco Specific Nitrosamines Toxaphene Phthalates
The Standard – August 2014
Dechlorane-602 Bisphenol A (BPA) Calculating Concentrations of Free Acid or Base from Salt Form New & Improved Isotope.com
The Standard – October 2013
Nonylphenol Added to List of Toxic Chemicals Human Biomonitoring: Attogram Level Sensitivity and Consequences for Analytical Standards Purity New Polychlorinated Naphthalene Standards Emerging Pesticides: Trifluralin
The Standard – June 2013
Using 13C-Labeled Standards and ID-HRMS for Low-Level PAH Determination in Water and Tissue Samples Triclosan in the News Interested in PAHs and PAH Metabolites? CIL’s New “Stable Isotopes for Mass Spectrometry” Catalog
The Standard – June 2012
CDC’s National Report on Human Exposure to Environmental Chemicals Reconstitutable Solutions EPA Perchlorate Regulations PAH Metabolites
The Standard – January 2012
Emerging Contaminants in the Great Lakes Determination of Glyphosate and AMPA EPA Report on Monitoring Parlar Compounds
The Standard – August 2011
Plasticizers in Food Are Now Substances of Higher Concern Bisphenol A Under Increased Scrutiny for Health Effects Endosulfans Added to Stockholm Convention POPs No Quantitation without Representation!
The Standard – December 2010
CIL's 2010 Environmental Contaminant Standards Catalog is now available! New 13C-Labeled Standard for Chemical Dispersant Used in Gulf Oil Spill EPA Takes Action on Chemicals Used in Dyes, Flame Retardants, and Industrial Detergents CIL Continues Development of Toxaphene Congener Standards
The Standard – June 2010
EPA Targets Cancer-Causing Contaminants Stockholm Convention Adds New POPs CIL Dioxin and Furan Standards Produced under ISO Guide 34 and ISO/IEC 17025:

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