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Biomolecular NMR

Membrane Proteins

Membrane proteins make up between 20% and 30% of all expressed proteins and are medically important, as they represent more than half of all present-day drug targets. Membrane proteins have hydrophobic exteriors, are relatively dynamic, and are produced at relatively low levels. These factors create difficulties in obtaining stable preparations for NMR analyses. Despite the significant functional importance of membrane proteins, determining structures for these proteins is much more challenging than for globular proteins.
 Fortunately, there are many sample preparation conditions that can be chosen for solution and solid state NMR. Most preparations require a detergent or phospholipid for proper solubilization and stability. In this regard, Cambridge Isotope Laboratories is pleased to be able to offer deuterated phospholipids and detergents from FB Reagents, Ltd., a trusted source for deuterated lipids.

 

Deuterated Phospholipids

Deuterated Phospholipids

The study of structure, dynamics, and small molecule binding properties of membrane proteins are of great interest within the field of Structural Biology and pharmaceutical drug development. The study of membrane proteins is made challenging because only certain phospholipids and detergents can be used to ensure the protein assumes the correct three dimensional fold and remains active. Cambridge Isotope Laboratories, Inc. is proud to offer deuterated phospholipids and detergents manufactured by FB Reagents. FB Reagents is a trusted source of high quality deuterated phospholipids and detergents used in NMR-based scientific research.