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The Isotope Gateway


The primary purpose of presenting a scientific poster at a conference or workshop is to allow and encourage direct discourse between peers so that existing research goals can better be met and perhaps new ones developed. Certainly, preparing and presenting a scientific poster is an important step of any graduate or post-doctoral student's career. The preparation of a successful poster requires not only scientific knowledge, but creativity and artistry to best convey the research story.

CIL recognizes the importance of scientific posters as a tool to disperse scientific knowledge and appreciates the effort needed to create them. Unfortunately, posters at a meeting are typically available for viewing for only a few days at most. This is one reason why CIL has established the Isotope Gateway.

Here is where CIL will give access to a collection of scientific posters and a bibliography of published scientific papers, all of which describe work utilizing stable isotope-labeled compounds. 

  • Scientific Posters
  • Reference Library




Absolute Quantification of Histone Deacetylase Isoforms in Alzheimer’s Disease Brain

Kyle W. Anderson and Illarion V. Turko

Incorporation Rate of Lysine-13C6 in Non-Generational Metabolic Labeling in Mice

Kevin Millis, Michael Ford, Richard Jones, Tasha Agreste, John Rod

In vivo Quantitative Proteomics of Somatosensory Cortical Synapses Shows Which Protein Levels Are Modulated by Sensory Deprivation

Jeffrey N. Savas, Margaret T. Butko, Beth Friedman, Claire Delahunty, Ford Ebner, Roger Y. Tsien, John R. Yates III


Protein Expression

Top 10 Tips for Producing 13C, 15N Protein Abundance

Deborah A. Berthold, Victoria J. Jeisy, Terry L. Sasser, John J. Shea, Heather L. Freicks, Gautan Shan, Chad M. Rienstra

Stable Istotope Labeled Cell Growth Media for Insect Yeast and Mammalian Cells

Lynne S. Batchelder, PhD, Senior Chemist
Cambridge Isotope Laboratories, Inc.

The Production and Use of a NIST-Traceable Standard Solution for Quantitative NMR Applications

Kris Dziewiszek, Kevin Millis, Joe Ray, Tim Eckersley
Cambridge Isotope Laboratories, Inc. and Baxter Healthcare Corporation

Hyperpolarized [1-13C] Pyruvate for Noninvasive Examination of Placental Metabolism and Nutrient Transport: A Feasibility Study in Pregnant Guinea Pigs

Lanette J. Friesen-Waldner, PhD, et al.
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada


Metabolic Research 


Profiling of Polar Organic Acids in Mouse Muscle Using Ion Chromatography/Mass Spectrometry 

Christopher Petucci1,2, Andrew V. Zelenin1,2, Jeffrey A. Culver1,2, Meghan Gabriel1, Ken Kirkbride3, Terri T. Christison3, and Stephen J. Gardell1,2

1. Metabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827
2. Southeast Center for Integrated Metabolomics (SECIM), Clinical and Translational Science Institute, 2004 Mowry Road, Gainesville, FL 32610
3. Thermo Fisher Scientific, 1214 Oakmead Parkway, Sunnyvale, CA 94088


New Reactive Organic Reagents for Footprinting Proteins

Cheng, Ming, Zhang, Bojie, Gross, Michael L.

1. Center for Biomedical and Bioorganic Mass Spectrometry, Department of Chemistry, Washington University in St. Louis, St. Louis, MO

Pathway Targeted Metabolomic Analysis in Oral Cancer Cells Using High Performance Ion Chromatography Coupling to A New HR/AM Orbitrap Mass Spectrometry

Junhua Wang1, Terri Christison1, Krista Backiel2, Grace Ji3, Shen Hu3, Linda Lopez1, Yingying Huang1

1. Thermo Fisher Scientific Inc, San Jose, CA
2. Cambridge Isotope Laboratories Inc., MA
3. School of Dentistry and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA
Daniel Krug1,2, Carsten Volz1, Aiko Barsch3, Chris Beecher4, Felice de Jong4, Rolf Müller1,2
1. Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Saarbrücken and Helmholtz Center for Infection Research (HZI), Braunschweig, Germany
2. Saarland University, Saarbrücken, Germany
3. Bruker Daltonik GmbH, Bremen, Germany
4. IROA Technologies, Ann Arbor, Michigan, USA

Bioprocess of a Yeast Fermentation Using the IROA Protocol

Chris Beecher and Felice de Jong
IROA Technologies LLC, Ann Arbor, MI


Betaine Is as Effective as Folate at Re-synthesizing Methionine for Protein Synthesis During Moderate Methionine Deficiency in Piglets 

Laura E. McBreairty, Jason L. Robinson, Scott Harding, Edward Randell, Janet A. Brunton, Robert F. Bertolo 

The impact of Dietary Methyl Donors on Whole-Body Methionine Partitioning in the Neonatal Piglet

Jason L. Robinson1, Laura E. McBreairty1, Scott V. Harding2, Janet A. Brunton1, Robert F. Bertolo1
1. Department of Biochemistry, Memorial University of Newfoundland, St. John’s, NL, Canada
2. Division of Nutrition Sciences, School of Medicine, Kings College London, London, UK






Percy, AJ; Byrns, S; PEnnington, SR. 2016. Clinical translation of MS- based, quantitative plasma proteomics: status, challenges . Expert Rev Proteomics. 13(7). PMID: 27341553 

Bao, XR; Ong, SE; Goldberger, O. 2016. Mitochondrial dysfunction remodels one-carbon metabolism in human cells.  Elife. 16;5. PMID: 27307216 

McConnell, BO; Antoniewicz, MR. 2016. Measuring the Composition and Stable-Isotope Labeling of Algal Biomass CArbohydrates via Gas Chromatography/ Mass Spectrometry. Anal Chem.  PMID: 27042946

Baughman, JM; Rose, CM; Koluman, G. 2016. NeuCode Proteomics Reveals Bap1 REgulation of Metabolism. Cell Rep.16(2): 583-95. PMID:27373151

Geary, B; Magee, K; Cash, P. 2016. Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid. Proteomics. 16(9). PMID: 26929125

Hecht, ES; McCord, JP; Muddiman, DC. 2016. A Quantitative Glycomics and Proteomics Combined Purification Strategy. J Vis Exp. 8;(109). PMID: 27023253

Baughman, JM; Rose, CM; Koluman, G. 2016. NeuCode Proteomics Revearls Bap1 Regulation of Metabolism. Cell Rep.S2211-1247(16)30738-0. PMID: 27373151 

Singh, SA; Andraski, AB; Pieper, B. 2016. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res. 57(4):714-28. PMID: 26862155

Henderson, CM; Vaisar, T; Hoofnagle, AN. 2016.  Isolating and Quantifying Plasma HDL Proteins by Sequential Density Gradient Ultracentrifugation and Targeted Proteomics.  Methods Mol Biol. 1410;105-20. PMID: 26867741

Singh, SA; Andraski, AB; Pieper, B. 2016. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring.  Journal of Lipid Res. 57(4):714-28. PMID: 26862155

Zhang, A; Uaesoontrachoon, K; Shaughnessy, C. 2015. The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse. Toxicol Rep. 838-849. PMID: 26213685

Wang, D; Krilich, J; Baudys, J.2015. Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay. Anal Biochem. 1;468:15-21. PMID: 25232998 

Cox, TR; Schoof, EM; Gartland, A. 2015. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data Brief. 5:621-5. PMID: 26649326

Hecht ES, Scholl EH, Walker SH, Taylor AD, Cliby WA, Motsinger-Reif AA, Muddiman DC. 2015. Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples. J Proteome Res. (10):4394-401 PMID:26347193

Mohammed, Y; Percy, AJ; Chambers, AG. 2015. Qualis-SIS: automated standard curve generation and quality assessment for multiplexed targeted quantitative proteomic experiments with labeled standards.J Proteome Res. 14(2):1137-46. PMID: 25546269

Percy, AJ; Mohammed, Y; Yang, J. 2015. A Standard kit for automated quantitative assessment of candidate protein biomakers in human plasma. Bioanalysis. 7(23):2991-3004. PMID: 26626236

Hecht, E.S.; McCord, J.P.; Muddiman, D.C. 2015. Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans. Anal Chem., 87(14):7305-12. PMID: 26086806

Murphy, JP; Everley, RA; Coloff, JL. 2014. Combining amine metabolomics and quantiteative proteomics of cancer cells using derivatization with isobaric tags. Anal Chem. 1;86(7):3585-93. PMID: 24611633

Hathout, Y; Marathi, RL; Rayavarapu. 2014. Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. Hum Mol Genet. 23(24):6458-69. PMID: 25027324 

Edfors, F; Bostrom, T; Forsstrom, B. 2014. Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins. Mol Cell Proteomics. 13(6):1611-24. PMID: 24722731

Bagert, JD; Xie, YJ; Sweredoski, MJ. 2014. Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture. Mol Cell Proteomics.13(5):1352-8. PMID: 24563536

McShane, AJ; Bajrami, B; Ramos, AA. 2014. Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane. J Proteome Res. 13(11):4676-85. PMID: 25227318

Percy, A.J.; Chambers, A.G.; Yang, J.; Hardie, D.B.; Borchers, C.H. 2014. Advances in multiplexed MRM-based protein biomarker quantitation toward clinical utility. Biochim Biophys Acta, 1844(5):917-26. PMID:23806606

Adhikari, J.; Fitzgerald, M.C. 2014  SILAC-Pulse Proteolysis: A Mass Spectrometry-Based Method for Discovery and Cross-Validation in Proteome-Wide Studies of Ligand Binding. J Am Soc Mass Spectrom. 25(12), 2073-83. PMID:25315461

Percy, AJ; Chambers, AG; Smith, DS. 2013. Standardized protocols for quality control of MRM-based plasma proteomic workflows. J Proteome Res. 12(1):222-33. PMID: 23245390

Zhang, C; Liu, Y; Andrews, PC. 2013. Quantification of histone modifications using 15N metabolic labeling. Methods. 61(3):236-43. PMID: 23454290

Hessling, B; Buttner, K; Hecker, M. 2013. Global relative quantification with liquid chromatography-matrix-assisted laser desorption ionization time-of-flight (LC-Maldi-TOF)--cross-validation with LTQ-Orbitrap proves reliability and reveals complementary ionization preferences. Mol Cell Proteomic. 12(10):2911-20. PMID: 23788530

Percy, AJ; Chambers, AG; Yang, J. 2013. Method and platform standardization in MRM-based quantitative plasma proteomics. J Proteomics. 16;95:66-76. PMID: 23933160

Chambers, AG; Percy, AJ; Yang, J. 2013. Multiplexed quantitation of endogenous proteins in dried blood spots by multiple reaction monitoring-mass spectrometry. Mol Cell Proteomics. 12(3):781-91. PMID: 23221968 

Butko, M.T.; Savas, J.N.; Friedman, B.; Delahunty, C.; Ebner, F.; Yates, J.R. III; Tsien, R.Y. 2013In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proc Natl Acad Sci, USA, 110, E726-E735. PMID:23382246

Walker, S.H.; Taylor, A.D.; Muddiman, D.C. 2013. Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): A Novel Glycan- Relative Quantification Strategy. J Am Soc Mass Spectrom, 24, 1376-1384. PMID:23860851

Hebert, A.S.; Merrill, A.E.; Bailey, D.J.; Still, A.J.; Westphall, M.S.; Strieter, E.R.; Pagliarini, D.J.; Coon, J.J. 2013. Neutron-encoded mass signatures for multiplexed proteome quantification. Journal Nat Methods, 332-4. PMID: 23435260

Rauniyar, N.; McClatchy, D.B.; Yates, J.R. III. 2013. Stable isotope labeling of mammals (SILAM) for in vivo quantitative proteomic analysis. Methods. [Preprint] Available from PMID:23523555

Rayavarapu, S.; Coley, W.; Cakir, E.; Jahnke, V.; Takeda, S.; Aoki, Y.; Gordish-Dressman, H.; Jaiswal, J.K.; Hoffman, E.P.; Brown, K.J.; Hathout, Y.; Nagaraju, K. 2013. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Mol Cell Proteomics. Jan 7. [Epub ahead of print] PMID:23297347

Rauniyar, N.; McClatchy, D.B.; Yates, J.R. III. 2013. Stable Isotope Labeling of Mammals (SILAM) for in vivo quantitative proteomic analysis. Methods. pii: S1046-2023(13)00077-7. doi: 10.1016 / j.ymeth.2013.03.008. [Epub ahead of print]. PMID:23523555

Simon, G.M.; Cheng, J.; Gordon, J.I. 2012. Quantitative assessment of the impact of the gut microbiota on lysine ε-acetylation of host proteins using gnotobiotic mice. Proc Natl Acad Sci USA, 109, 11133-11138. PMID:22733758

Dey, A.; Seshasayee, D.; Noubade, R.; French, D.M.; Liu, J.; Chaurushiya, M.S.; Kirkpatrick, D.S.; Pham, V.C.; Lill, J.R.; Bakalarski, C.E.; Wu, J.; Phu, L.; Katavolos, P.; Lafave, L.M.; Abdel-Wahab, O.; Modrusan, Z.; Seshagiri, S.; Dong, K.; Lin, Z.; Balazs, M.; Suriben, R.; Newton, K.; Hymowitz, S.; Garcia-Manero, G.; Martin, F.; Levine, R.L.; Dixit, V.M. 2012. Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation. Science337, 1541-1546. PMID:22878500

Sharma, N.; Medikayala, S.; Defour, A.; Rayavarapu, S.; Brown, K.J.; Hathout, Y.; Jaiswal, J.K. 2012. Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles. J Biol Chem, 287, 30455-30467. PMID:22778268

Savas, J.N.; Toyama, B.H.; Xu, T.; Yates, J.R., III; Hetzer, M.W. 2012. Extremely long-lived nuclear pore proteins in the rat brain. Science, 335, 942. PMID:22300851

Price, J.C.; Khambatta, C.F.; Li, K.W.; Bruss, M.D.; Shankaran, M.; Dalidd, M.; Floreani, N.A.; Roberts, L.S.; Turner, S.M.; Holmes, W.E.; Hellerstein, M.K. 2012. The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics. Mol Cell Proteomics, 11, 1801-1814.PMID:22984287

Walker, S.H.; Lilley, L.M.; Enamorado, M.F.; Comins, D.L.; Muddiman, D.C. 2011. Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry. J Am Soc Mass Spectrom, 22, 1309-1317. PMID:21953184

Stergachis, A.B.; MacLean, B.; Lee, K.; Stamatoyannopoulo, J.A.; MacCoss, M.J. 2011. Rapid empirical discovery of optimal peptides for targeted proteomics. Nature Methods, 8, 1041–1043. 10.1038 /nmeth.1770. PMID:22056677

Hoofnagle et al. 2010Clin Chem, 56, 1561-70.

Park, S.K., et al. 2008. A quantitative analysis software tool for mass spectrometry-based proteomics. Nat Methods, 5, 319-322. PMID:18345006

McClatchy, D.B.; Yates, J.R.I. 2008. Stable Isotope Labeling of Mammals (SILAM). CSH Protocols, doi:10.1101/pdb.prot 4940. PMID:21356771

Goshima, N.; Kawamura, Y.; Fukumoto, A.; Miura, A.; Honma, R.; Sato, R.; Wakamatsu, A.; Yamamoto, J.; Kimura, K.; Nishikawa, T., et al. 2008. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nature Methods, 5, 1011-1017. PMID:19054851

McClatchy, D.B.; Liao, L.; Park, S.K.; Venable, J.D.; Yates, J.R., III. 2007. Quantification of the synaptosomal proteome of the rat cerebellum during post-natal development. Genome Res, 17, 1378-1388. PMID:17675365

McClatchy, D.B.; Dong, M.Q.; Wu, C.C.; Venable, J.D.; Yates, J.R., III. 200715N metabolic labeling of mammalian tissue with slow protein turnover. J. Proteome Res, 6, 2005-2010. PMID:17375949

McClatchy, D.B., et al. 200715N metabolic labeling of mammalian tissue with slow protein turnover. J Proteome Res, 6, 2005-10. PMID:17375949

Mann, M. 2006. Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol, 7, 952-958. PMID:17139335

Amanchy, R.; Kalume. D.E.; Pandey, A. 2005. Stable isotope labeling with amino acids in cell culture (SILAC) for studying dynamics of protein abundance and posttranslational modifications. Sci STKE, 267, 1-20. PMID:15657263

Shadforth, I.P., et al. 2005. i-Tracker: for quantitative proteomics using iTRAQ®BMC Genomics, 6, 145. PMID:16242023

MacCoss, M.J., et al. 2005. Measurement of the isotope enrichment of stable isotope-labeled proteins using high-resolution mass spectra of peptides. Anal Chem, 77, 7646-53. PMID:16316172

Amanchy, R.; Kalume. D.E.; Pandey, A. 2005. Stable isotope labeling with amino acids in cell culture (SILAC) for studying dynamics of protein abundance and posttranslational PMID:15657263

Kratchmarova, I.; Blagoev. B.; Haack-Sorensen. M.; Kassem, M.; Mann, M. 2005. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science, 308, 1472-1477. PMID:15933201

Sadygov, R.; Cociorva, D.; Yates, J.R., III. 2004. Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book. Nature Methods, 1, 195-202. Res, 17, 1378-1388. PMID:15789030

Blagoev, B.; Ong, S.E.; Kratchmarova. I.; Mann. M. 2004. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nature Biotechnology, 22, 1139-1145. PMID:15314609

Wu, C.C.; MacCoss, M.J.; Howell, K.E.; Matthews, D.E.; and Yates, J.R., III. 2004. Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem, 76, 4951-4959. PMID:15373428

Wu, C.C., et al. 2004. Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem, 76, 4951-9. PMID:15373428

Ficarro, S.B., et al. 2002. Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiaeNat Biotechnol, 20, 301-5. PMID:11875433

Ong, S.E.; Blagoev, B.; Kratchmarova, I.; Kristensen, D.B.; Steen. H.; Pandey. A.; Mann, M. 2002. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics, 1, 376-386. PMID:12118079

Goshe, M.B.; Conrads, T.P.; Panisko, E.A.; Angell, N.H.; Veenstra, T.D.; Smith, R.D. 2001. Phosphoprotein isotope-coded affinity tag (PhIAT) approach for isolating and quantitating phosphopeptides in proteome-wide analyses. Anal Chem, 73, 2578-2586. PMID:11403303

Conrads, T.P.; Alving, K.; Veenstra, T.D.; Belov, M.E.; Anderson, G.A.; Anderson, D.J.; Lipton, M.S.; Pasa-Tolic, L.; Udseth, H.R.; Chrisler, W.B.; Thrall, B.D.; Smith, R.D. 2001. Quantitative analysis of bacterial and mammalian proteomes using a combination of cysteine affinity tags and 15N-metabolic labeling. Anal Chem73, 2132–2139. PMID:11354501

Washburn, M.P.; Wolters, D.; Yates, J.R., III. 2001. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol, 19, 242-247. PMID:11231557

Pasa-Tolic, L.; Jensen, P.K.; Anderson, G.A.; Lipton, M.S.; Peden, K.K.; Martinovic, S.; Tolic, N.; Bruce, J.E.; Smith, R.D. 1999. High throughput proteome-wide measurements of protein expression using mass spectrometry. J Am Chem Soc, 121, 7949-7950. JACS DOI:10.1021/ja991063o

Oda, Y.; Huang, K.; Cross, F.R.; Crowburn, D.; Chait, B.T. 1999. Accurate quantitation of protein expression and site-specific phosphorylation. Proc Natl Acad Sci USA, 96, 6591-6596. PMID:10359756

Gygi, S.P.; Rist, B.; Gerber, S.A.; Turecek, F.; Gelb, M.H.; Aebersold, R. 1999. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol, 17, 994-999. PMID:10504701

Barlos, K.; Gatos. D. 1999. 9-Fluorenylmethyloxycarbonyl/tButyl-based convergent protein synthesis. Biopolymers, 51, 266-278.PMID:10618595

Fujiwara, Y.; Akaji, K.,; Kiso, Y. 1994. Racemization-Free Synthesis of C-Terminal Cysteine-Peptide Using 2-Chlorotrityl Resin. Chem Pharm Bull, 42, 724-726.PMID:8004723

Barlos, K.; Gatos, D.; Kallitsis, J.; Papaphotiu, G.; Sotiriu, P.; Yao, W.Q.; Schafer, W. 1989. Synthesis of Protected Peptide-Fragments Using Substituted Triphenylmethyl Resins. Tetrahedron Lett, 30, 3943-3946.

McNurlan, M.A.; Pain, V.M.; Garlick, P.J. 1980. Conditions that alter rates of tissue protein synthesis in vivoBiochem Soc Trans, 8, 283-5. PMID:6772491



Metabolic Research


Geary, B.; Magee, K.; Cash, P.; Young, IS.; Whitefield, PD.; Doherty, MK. 2016. Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid. Proteomics. 10. 1002. PMID:26929125

Sellers, K.; Fox, M.; Bousamra, M.; Slone, S. 2015. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest. 125. 687-698. PMID:25607840

Buescher, J.; Antoniewicz, M.; Boros, L.; Burgess, S. 2015. A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34. 189-201. PMID:25731751

Mayers, J.R., et al., 2014. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Meddoi: 10.1038/nmp.3686. PMID:25261994

Lewis, C., et al. 2014. Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells. Mol Cell, 55, 253-263. PMID:24882210

Fan, J.; Ye, J.;Kamphorst, J.; Shlomi, T. 2014. Quantitative flux analysis reveals folate-dependent NADPH production. Nature. 510. 298-302. PMID:24805240

Marini, J.C., et al. 2012. Arginine and Ornithine Are the Main Precursors for Citrulline Synthesis in Mice. J Nutrition, 142, 572-580. PMID:22323761


Biomolecular NMR 


Harbers, M. 2014. Wheat germ systems for cell-free protein expression. FEBS. 25;588(17):2762-73. PMID: 24931374

Sinnige, T.; Daniels, M.; Baldus, M.; Weingarth. M. 2014. Proton Clouds to Measure Long-Range Contacts between Nonexchangeable Side Chain Protons in Solid-State NMR. JACS, 136, 4452-4455. PMID: 24467345

Weingarth, M.; Baldus., M. 2013.  Solid-State NMR-Based Approaches for Supramolecular Structure Elucidation. Accounts of Chem Res, 46(9)2037–2046. PMID: 23586937

Loquet, A.; Habenstein, B.; Lange, A. 2013. Structural Investigations of Molecular Machines by Solid-State NMR. Acccounts of Chem Res, 46(9), 2013-2079. PMID: 23496894

Verardi, R.; Traaseth, N.J.; Masterson, L. R.; Vostrikov, V.V.; Veglia, G. 2012. Isotope Labeling for Solution and Solid-State NMR Spectroscopy of Membrane Proteins. Adv Ex Med Bio, 992, 35-62. PMID: 23076578

Huber, M.; Hiller, S.; Schanda, P.; Ernst, M.; Bockmann, A.; Verel, R.; Meier, B.H. 2012. A Proton-Detected 4D Solid-State NMR Experiment for Protein Structure Determination. Chem Phys Chem, 12(5), 915-918. PMID: 21442705

Park, S.H.; Das, B.B.; Casagrande. F.; Tian, Y.; Nothnagel, H.J.; Chu, M.; Kiefer, H.; Maier, K.; De Angelis, A.A.; Marassi, F.M.; Opella, S.J. 2012. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature, 491, 779-783. PMID: 23086146

Takeuchi, K.; Frueh, D.P.; Sun, Z.Y.; Hiller, S.; Wagner, G. 2010. HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment. J Biomol NMR, 47, 55-63. PMID: 21110064

Thakur, C.; Sama, J.; Jackson, M.; Chen, B.; Dayie, T. 2010. Selective 13C labeling of nucleotides for large RNA NMR spectroscopy using an E. coli strain disabled in the TCA cycle. J Biomol NMR, 48, 179-192. PMID:21057854

Wagner, G.; Lu, K.; Miyazaki, Y.; Summers M.F. 2010. A topical issue: production and labeling of biological macromolecules for NMR investigations J Biomol NMR, 46, 113-125.  PMID:19924385

Krishnarjuna, B.; Jaiupuria, G.; Thakur, A.D.; Silva, P.; Atreya, H.S. 2010. Amino acid selective unlabeling for sequence specific resonance assignments in proteins. J Biomol NMR, 49, 38-51. PMID:21153044

Zhu, J.; Ye, E.; Terskikh, V.; and Wu, G. 2010. Solid-state 17O NMR spectroscopy of large protein-ligand complexes. Angew Chem Int Ed, 49, 8399-8402. PMID:20672261

Takahashi, H.; Shimada, I. 2010. Production of isotopically labeled heterologous proteins in non-E. coli prokaryotic and eukaryotic cells. J Biomol NMR, 46, 3-10.PMID:19787297

Filipp, F.V.; Sinha, N.; Jairam, L.; Bradley, J.; Opella, S.J. 2009. Labeling strategies for 13C-detected aligned-sample solid-state NMR of proteins. J Magn Reson, 201, 121-130. PMID:19781966

Ayala, I.; Sounier, R.; Use, N.; Gans, P.; Boisbouvier, J. 2009. An efficient protocol for the complete incorporation of methyl-protonated alanine in perdeuterated protein. J Biomol NMR, 43, 111-9.PMID:19115043

Wylie, B.J. 2009. Protein Structure Refinement Using 13Cα Chemical Shift Tensors. J Am Chem Soc, 118, 9255-9264. PMID:19123862

Tong, K.I.; Yamamoto, M.; Tanaka, T. 2008. A simple method for amino acid selective isotope labeling of recombinant proteins in E. coli. J Biomol NMR, 42, 59-67. PMID:18762866

Hiller, S.; Garces, R.G.; Malia, T.J.; Orekhov, V.Y.; Colombini, M.; and Wagner, G. 2008. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science, 321, 1206-1210. PMID:18755977

Zhou, Y.; Cierpicki, T.; Jimenez, R.H.; Lukasik, S.M.; Ellena, J.F.; Cafiso, D.S.; Kadokura, H.; Beckwith, J.; and Bushweller, J.H. 2008. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell, 31, 896-908.PMID:18922471

Takeuchi, K.; Ng, E.; Malia, T.J.; Wagner, G. 2007. 1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins. J Biomol NMR, 38 (1), 89-98. PMID:17390105

Isaacson, R.L.; Simpson, P.J.; Liu, M.; Cota, E.; Zhang, X.; Freemont, P.; Matthews, S. 2007. A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues. J Am Chem Soc, 129, 15428-9. PMID:18041839

Kainosho, M.; Torizawa, T.; Iwashita, Y.; Terauchi, T.; Ono, A.M.; Güntert, P. 2006. Optimal isotope labeling for NMR protein structure determinations. Nature, 440, 52–57. PMID:16511487

Frueh, D.P.; Vosburg, D.A.; Walsh, C.T.; Wagner, G. 2006. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Biomol NMR, 34, 31-40. PMID:16637644

Chen, C.Y.; Cheng, C.H.; Chen, Y.C.; Lee, J.C.; Chou, S.H.; Huang, W.; Chuang, W.J. 2006. Preparation of amino-acid-type selective isotope labeling of protein expressed in Pichia pastoris. Proteins, 62, 279-87. PMID:16283643

Davis, J.H.; Tonelli, M.; Scott, L.G.; Jaeger, L.; Williamson, J.R.; Butcher, S. 2005. Helical packing in solution: NMR structure of a 30 kDa GAAA tetraloop-receptor complex. J Mol Biol, 352, 371-382. PMID:16002091

Tugarinov, V.; Kay, L.E. 2005. Methyl groups as probes of structure and dynamics in NMR studies of high-molecular-weight proteins. ChemBioChem, 6, 1567-77. PMID:16075427

Tyler, R.C.; Sreenath, H.K.; Singh, S.; Aceti, D.J.; Bingman, C.A.; Markley, J.L.; Fox, B.G. 2005. Auto-induction medium for the production of [U-15N]- and [U-13C, U-15N]-labeled proteins for NMR screening and structure determination. Protein Expr Purif, 40, 268-278. PMID:15766868

Torizawa, T.; Shimizu, M.; Taoka, M.; Miyano, H.; Kainosho, M. 2004. Efficient production of isotopically labeled proteins by cell-free synthesis: A practical protocol. J Biomol NMR, 30, 311–325. PMID:15754057

Pickford, A.R.; O‘Leary, J.M. 2004. Isotopic labeling of recombinant proteins from the methylotrophic yeast Pichia pastoris. Methods Mol Biol, 278, 17-33. PMID:15317988

Rodriguez-Mias, R.; Pellecchia, M. 2003. Use of Selective Trp Side Chain Labeling to Characterize Protein-Protein and Protein-Ligand Interactions by NMR Spectroscopy. JACS, 125, 2892-2893. PMID: 12617653

Castellani, F.; van Rossum, B.; Diehl, A.; Schubert, M.; Rhbein, K.; Oschkinat, H. 2002. Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy. Nature, 420, 98-102. PMID:12422222

Hwang, P.M.; Choy, W.Y.; Lo, E.I.; Chen, L.; Forman-Kay, J.D.; Raetz, C.R.; Prive, G.G.; Bishop, R.E.; and Kay, L.E. 2002. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci USA, 99, 13560-13565. PMID:12357033

Rodriguez, E.; Krishna, N.R. 2001. An economical method for 15N / 13C isotopic labeling of proteins expressed in Pichia pastoris. J Biochem, 130, 19-22. PMID:11432775

Cowburn, D. and Muir, T.W. 2001. Segmental isotopic labeling for structural biological applications of NMR. Methods Enzymol, 339, 41–54. PMID:15317990

Atreya, H.S.; Chary, K.V.R. 2001. Selective unlabeling of amino acids in fractionally 13C-labeled proteins: An approach for stereospecific NMR assignments of CH3 groups in Val and Leu residues. J Biomol NMR, 19, 267-272. PMID:11330814

Morgan, W.D.; Kragt, A.; Feeney, J. 2000. Expression of deuterium-isotope-labeled protein in the yeast Pichia pastoris for NMR studies. J Biomol NMR, 17, 337-47. PMID:11014598

Goto, N.K.; Gardner, K.H.; Mueller, G.A.; Willis, R.C.; Kay, L.E. 1999. A robust and cost-effective method for the production of Val, Leu, Ile (δ1) methyl-protonated 15N-, 13C-, 2H-labeled proteins. J Biomol NMR, 13, 369-374.PMID:10383198

Wood, M.J.; Komives, E.A. 1999. Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation. J Biomol NMR, 13, 149-59. PMID:10070756

Massou, S.; Puech, V.; Talmont, F.; Demange, P.; Lindley, N.D.; Tropis, M.; Milon, A. 1999. Heterologous expression of a deuterated membrane-integrated receptor and partial deuteration in methylotrophic yeasts. J Biomol NMR, 14, 231-9. PMID:10481275

Hong, M. 1999. Determination of multiple phi-torsion angles in proteins by selective and extensive 13C labeling and two-dimensional solid-state NMR. J Magn Reson, 139, 389-401. PMID:10423377

Gardner, K.H.; Kay, L.E. 1997. Production and Incorporation of 15N, 13C, 2H (1H δ1 methyl) Isoleucine into Proteins for Multidimensional NMR Studies. J Am Chem Soc, 119, 7599-7600. JACS DOI: 10.1021/ja9706514

Batey, R.T. 1996. Improved large-scale culture of Methylophilus methylotrophus for 13C / 15N labeling and random fractional deuteration of ribonucleotides. Methods Enzymol, 177, 23-43. PMID: 8972874

Vuister, G.W.; Kim, S.J.; Wu, C.; Bax, A. 1994. 2D and 3D NMR study of phenylalanine residues in proteins by reverse isotopic labeling. J Am Chem Soc, 116, 9206-9210 JACS DOI:10.1021/ja00099a041

Ikura, M.; Kay, L.E.; Bax, A.1990. A novel approach for sequential assignment of 1H, 13C, and 15N spectra of larger proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to Calmodulin. Biochemistry, 29, 4659-4667. PMID: 2372549


NMR Solvents and Consumables


Wei, H., et al. 2014. Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications. Drug Discovery Today, 19.1: 95-102. PMID:23928097

Singh, H.; Busenlehner, L.S. 2014. Probing backbone dynamics with hydrogen/deuterium exchange mass spectrometry. Protein Dynamics. Humana Press. 81-99. PMID:24061917

Shariatgorji, M.; Svenningsson, P.; Andrén, P.E. 2014. Mass spectrometry imaging, an emerging technology in neuropsychopharmacology. Neuropsychopharmacology 39.1: 34-49. PMID:23966069

Tugarinov, V. 2014. Indirect use of deuterium in solution NMR studies of protein structure and hydrogen bonding. Prog Nucl Magn Reson Spectrosc, 77: 49-68. PMID:24411830

Lam, W.W., et al. 2014. Metabolite Identification in Drug Discovery. Optim Drug Discovery, Humana Press. 445-459. Springer Link DOI: 10.1007/978-1-62703-742-6_26

Gronenberg, W., et al. 2014. Honeybees (Apis mellifera) learn to discriminate the smell of organic compounds from their respective deuterated isotopomers. Proc R Soc B, 281.1778: 20133089 PMID:24452031

Xu, G., et al. 2014. Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes. J Med Chem, 57(4), 1236-1251. PMID:24456245

Williams, R.M.; Pang, S.H.; Medlin, J.W. 2014. OH versus CH bond scission sequence in ethanol decomposition on Pd (111). Surf Sci, 619: 114-118. Science Direct DOI:10.1016/j.susc.2013.09.014

Sawadjoon, S., et al. 2014. Mechanistic Insights into the Pd‐Catalyzed Direct Amination of Allyl Alcohols: Evidence for an Outer‐sphere Mechanism Involving a Palladium Hydride Intermediate. Chem – Eur J, 20(6), 1461-1764. PMID:24403056

Gimeno, A., et al. 2014. Competitive Gold‐Activation Modes in Terminal Alkynes: An Experimental and Mechanistic Study. Chem – Eur J, 20.3: 683-688. PMID: 24318565

Pal, S.; Zavalij, P.Y.; Vedernikov, A.N. 2014. Oxidative C (sp3)-H bond cleavage, C-C and C=C coupling at a boron center with O2 as the oxidant mediated by platinum (ii). Chem Commun, 50(40), 5376-5378. PMID:24287586

Perkola, N.; Sainio, P. 2014. Quantification of four artificial sweeteners in Finnish surface waters with isotope dilution mass spectrometry. Environ Pollut,184, 391-396. PMID:24100049

White, S.J.; Jamie, I.M.; Angove, D.E. 2014. Chemical characterisation of semi-volatile and aerosol compounds from the photooxidation of toluene and NOX. Atmos Environ, 83, 237-244. Science Direct DOI:10.1016/j.atmosenv.2013.11.023

Shao, M., et al. 2014. The isotopic effects of deuteration on optoelectronic properties of conducting polymers. Nat Commun, 5. PMID:24458188

Boillat, P., et al. 2014. Evaluation of Neutron Imaging for Measuring Phosphoric Acid Distribution in High Temperature PEFCs. J Electrochem Soc, 161,3: F192-F198. ECS DOI:10.1149/2.023403jes

Hirata, S., et al. 2014. Relationship between room temperature phosphorescence and deuteration position in a purely aromatic compound. Chem Phys Lett, 591, 119-125. Science Direct DOI: 10.1016/j.cplett.2013.11.019

Fulmer, G.R., et al. 2010. NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist. Organometallics, 29.9: 2176-2179. ACS DOI: 10.1021/om100106e

Kushner, D. J.; Baker, A.; Dunsta ll T.G. 1999. Pharmacological uses and perspectives of heavy water and deuterated compounds. Can J Physiol Pharmacol, 77.2: 79-88. PMID:10535697

Gottlieb, H.E.; Kotlyar, V.; Nudelman, A. 1997. NMR chemical shifts of common laboratory solvents as trace impurities. J Org Chem, 62.21: 7512-7515. PMID:11671879


Standards for Environmental Analysis


Zhang, Q.; Chen, Z.; Li, Y.; Wang, P.; Zhu, C.; Gao, G.; Xiao, K.; Sun, H.; Zheng, S.; Liang, Y.; Jiang, G. 2015. Occurrence of organochlorine pesticides in the environmental matrices from King George Island, west Antarctica. Environ Pollut, 206; 142-149. PMID:26162333

Liu, G.; Lv, P.; Jiang, X.; Nie, Z.; Liu, W.; Zheng, M. 2015. Identification and preliminary evaluation of polychlorinated naphthalene emissions from hot dip galvanizing plants. Chemosphere, 118; 112-116. PMID:25083943

Liu, G.; Lv, P.; Jiang, X.; Nie, Z.; Zheng, M. Identifying Iron Foundries as a New Source of Unintentional Polychlorinated Naphthalenes and Characterizing Their Emission Profiles. 2014Environ Sci Technol, 48(22); 13165-72. PMID:25313855

Liu, G.; Liu, W.; Cai, Z.; Zheng, W. 2013. Concentrations, profiles, and emission factors of unintentionally produced persistent organic pollutants in fly ash from coking processes. J Haz Mater, 261; 421-426. PMID:23973475

Liu, G. Zheng, M.; Du, B.; Nie, Z.; Zhang, B.; Liu, W.; Li, C.; Hu, J. 2012. Atmospheric emission of polychlorinated napthalenes from iron ore sintering processes. Chemosphere, 89; 467-472. PMID:22739541

Liu, G.; Zheng, M.; Lv, P.; Liu, W.; Wang, C.; Zhang, B. Xiao, K. 2010. Estimation and Characterization of Polychlorinated Naphthalene Emission from Coking Industries. Environ Sci Technol, 44; 8156-8161.PMID:20886822




Hsu, WH.; Jiang, SJ.; Sahayam, AC. 2013. Determination of Cu, As, Hg and Pb in vegetable oils by elctrothermal vaporization inductively coupled plasma mass spectrometry with palladium nanoparticles as modifier. Talanta. 117. 268-72.PMID:24209340

Busto, ME.; Montes-Bayon, M.; Sanz-Medel, A. 2006. Accurate determination of human serum transferrin isoforms: Exploring metal-specific isotope dilution analysis as a quantitative proteomic tool. Analytical Chemistry. 78(24) 8218-26.PMID: 17165810

Chang, CW.; Fennimore, AM.; Afanasiev, A.; Okawa, D.; Ikuno, T.; Garcia, H.; Li, D.; ZettI, A. 2006. Isotope efect on the thermal conductivity of boron nitride nanoubes. 97(8). 085901. PMID:17026316

Encinar, JR.; Villar, MI.; Santamaria, VG.; Alonso, JL.; Sanz-Medel, A. 2001. Simultaneous determination of mono-, di-, and tributyltin in sediments by isotope dilution analysis using gas chromatography--ICPMS. PMID:11467570

Matlock, MM.; Howerton, BS.; Atwood, DA. 2001. Irreversible precipitation of mercury and lead. Journal of Hazard Materials. 84(1). 73-82. PMID:11376885


Xu, J.; Zhu, P.; Gan, Z.; Sahar, N.; Tecklenburg, M.; Morris, MD.; Kohn, DH.; Ramamoorthy, A. 2010. Natural-abundance 43Ca solid-state NMR spectroscopy of bone. Journal of  American Chemical Society. 132(33). 11504-9. PMID:20681578

Miwa, K.; Takano, J.; Fujiwara, T. 2006. Improvement of seed yields under boron-limiting conditions through overexpression of BOR1, a boron transporter for xylem loading, in Arabidopsis thaliana. The Plant Journal: for cell and molecular biology. 46(6). 1084-91. PMID:16805739

Takano, J.; Miwa, K.; Yuan, L.; von Wiren, N.; Fujiwara, T. 2005. Endocytosis and degradation of BOR1, a boron transporter of Arabidopsis thaliana, regulated by boron availability. Proceedings of the National Academy of Sciences of the United States of America. 102(34). 12276-81. PMID:16103374

Lee, KH.; Liu, SH.; Jiang, SJ. 1998. Determination of cadmium and lead in urine by electrothermal vaporization isotope dilution inductively coupled plasma mass spectrometry. The Analyst. 123(7). 1557-60. PMID:9830167

13C Breath Test Substrates 

Safgren SL, Suman VJ, Kosel ML, Gilbert JA, Buhrow SA, Black JL, Northfelt DW, Modak AS, Rosen D, Ingle JN, Ames MM, Reid JM, Goetz MP. 2015. Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen. Pharmacogenet Genomics. 25(4):157-63. PMID: 25714002

Modak, AS. 2013. Regulatory issues on breath tests and updates of recent advances on [13C]-breath tests. J Breath Res. 7(3):037103. PMID: 23774086 

Opdam FL, Modak AS, Gelderblom H, Guchelaar HJ. 2013.Breath tests to phenotype drug disposition in oncology. Clin Pharmacokinet. 52(11):919-26. PMID: 23868281  

Opdam, FL; Dezentje, VO; den Hartigh, J; Modak, AS; Vree, R; Batman, E; Smorenburg, CH; Nortier, JW; Gelderblom, H; Guchelaar, HJ. 2013. The use of the 13C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels. Cancer Chemother Pharmacol. 71(3):593-601. PMID: 23228987

Thacker, DL; Modak, A; Flockhart, DA; Desta Z. 2013. Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? J Breath Res. 7(1):016001. PMID: 23257668

Modak, A; Durso, R; Josephs, E; Rosen D. 2012. A rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease. J Parkinsons Dis. 2(4):349-56. PMID: 23646099

Modak, AS. 2012. Phenotype Breath Tests as Companion Diagnostic Tests (CDx) in Clinical Trials of Drugs. J Pharmacogenomics Pharmacoproteomics. 3(1), (2pp).

Modak, AS. 2011. Barriers to overcome for transition of breath tests from research to routine clinical practice. J Breath Res. 5(3):030202. PMID: 21900729 

Thacker DL, Modak A, Nguyen PD, Flockhart DA, Desta Z. 2011. Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity. Chirality. 23(10):904-9. PMID: 21935988

Modak, AS. 2010. Breath biomarkers for personalized medicine. Personalized Medicine. 7(6): 640-51. Future Medicine

Modak, AS. 2010. Single time point diagnostic breath tests: a review. J Breath Res. 4(1):017002. PMID: 21386204 

Ezzeldin HH, Acosta EP, Mattison LK, Fourie J, Modak A, Diasio RB. 2009. (13)C-5-FU breath test current status and future directions: a comprehensive review. J Breath Res. 3(4):047002. PMID: 21386199

Modak, AS. 2009. 13C breath tests in personalized medicine: fiction or reality? Expert Review of Molecular Diagnostics. 9(8): 805-815. Tandfonline

Modak, AS. 2009. Rapid identification of hepatic CYP2C19 activity using a novel and non-invasive [13C]-pantoprazole breath test. Journal of Pharmacology and Experimental Therapeutics. 329, 297-305.

Modak, AS. 2008. Diagnostic breath tests in personalized medicine. Expert Review. Mol. Diagn. 8(5), 563-564. Tandfonline

Leeder JS, Pearce RE, Gaedigk A, Modak A, Rosen DI. 2008. Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype. J Clin Pharmacol. 48(9):1041-51. PMID: 18728242

Freeman RB, Dixon M, Horth B, Melanson AM, Palladino MB, Kinzel J, Rohrer R, Cooper J, Reid J, Modak AS. 2007. L-[1-(13)C] phenylalanine breath test for monitoring hepatic function after living donor liver transplant surgery. J Breath Res. 1(2):026002. PMID: 21383436

Modak AS. 2007. Stable isotope breath tests in clinical medicine: a review. J Breath Res. 1(1):014003. PMID: 21383429

Modak, AS. 2007. Phenotype breath tests for personalized medicine. Journal of Labelled Compounds and Radiopharmaceuticals. 50 (5-6). 571-573. Online Library.

Modak AS, Reid JM, Williams LA, Hobbs GR. 2007. A simple non-invasive method to detect and monitor hypercapnia: the sodium [13C]bicarbonate breath test. Isotopes Environ Health Stud. 43(1):23-9. PMID: 17454270

Modak, AS. 2006. Racial Differences in Dihydropyrimidine Dehydrogenase Activity: Increased Prevalence of DPD Deficiency in African Americans Compared to Caucasians. Clin Can Res. 12, 5491-5.

Mattison LK, Ezzeldin H, Carpenter M, Modak A, Johnson MR, Diasio RB. 2004. Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. Clin Cancer Res. 15;10(8):2652-8. PMID: 15102667

Adhikari, J.; Fitzgerald, M.C. 2014  SILAC-Pulse Proteolysis: A Mass Spectrometry-Based Method for Discovery and Cross-Validation in Proteome-Wide Studies of Ligand Binding. J Am Soc Mass Spectrom. 25(12), 2073-83. PMID:25315461










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