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The Isotope Gateway

THE ISOTOPE GATEWAY

The primary purpose of presenting a scientific poster at a conference or workshop is to allow and encourage direct discourse between peers so that existing research goals can better be met and perhaps new ones developed. Certainly, preparing and presenting a scientific poster is an important step of any graduate or post-doctoral student's career. The preparation of a successful poster requires not only scientific knowledge, but creativity and artistry to best convey the research story.

CIL recognizes the importance of scientific posters as a tool to disperse scientific knowledge and appreciates the effort needed to create them. Unfortunately, posters at a meeting are typically available for viewing for only a few days at most. This is one reason why CIL has established the Isotope Gateway.

Here is where CIL will give access to a collection of scientific posters and a bibliography of published scientific papers, all of which describe work utilizing stable isotope-labeled compounds. 

 
  • Scientific Posters
  • Reference Library

 

Proteomics

 
 

Absolute Quantification of Histone Deacetylase Isoforms in Alzheimer’s Disease Brain

Kyle W. Anderson and Illarion V. Turko
 
 

Incorporation Rate of Lysine-13C6 in Non-Generational Metabolic Labeling in Mice

Kevin Millis, Michael Ford, Richard Jones, Tasha Agreste, John Rod
 
 

In vivo Quantitative Proteomics of Somatosensory Cortical Synapses Shows Which Protein Levels Are Modulated by Sensory Deprivation

Jeffrey N. Savas, Margaret T. Butko, Beth Friedman, Claire Delahunty, Ford Ebner, Roger Y. Tsien, John R. Yates III

 

Protein Expression
 

Top 10 Tips for Producing 13C, 15N Protein in Abundance

Deborah A. Berthold, Victoria J. Jeisy, Terry L. Sasser, John J. Shea, Heather L. Freicks, Gautan Shan, Chad M. Rienstra

Stable Istotope Labeled Cell Growth Media for Insect, Yeast and Mammalian Cells

Lynne S. Batchelder, PhD, Senior Chemist
Cambridge Isotope Laboratories, Inc.
 

The Production and Use of a NIST-Traceable Standard Solution for Quantitative NMR Applications

Kris Dziewiszek, Kevin Millis, Joe Ray, Tim Eckersley
Cambridge Isotope Laboratories, Inc. and Baxter Healthcare Corporation

Hyperpolarized [1-13C] Pyruvate for Noninvasive Examination of Placental Metabolism and Nutrient Transport: A Feasibility Study in Pregnant Guinea Pigs

Lanette J. Friesen-Waldner, PhD, et al.
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
 

 

Metabolic Research 

 

Profiling of Polar Organic Acids in Mouse Muscle Using Ion Chromatography/Mass Spectrometry 

Christopher Petucci1,2, Andrew V. Zelenin1,2, Jeffrey A. Culver1,2, Meghan Gabriel1, Ken Kirkbride3, Terri T. Christison3, and Stephen J. Gardell1,2

1. Metabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL, USA
2. Southeast Center for Integrated Metabolomics (SECIM), Clinical and Translational Science Institute, 2004 Mowry Road, Gainesville, FL, USA
3. Thermo Fisher Scientific, 1214 Oakmead Parkway, Sunnyvale, CA, USA

 

New Reactive Organic Reagents for Footprinting Proteins

Cheng, Ming; Zhang, Bojie; Gross, Michael L.

1. Center for Biomedical and Bioorganic Mass Spectrometry, Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA
 

Pathway Targeted Metabolomic Analysis in Oral Cancer Cells Using High Performance Ion Chromatography Coupling to A New HR/AM Orbitrap Mass Spectrometry

Junhua Wang1, Terri Christison1, Krista Backiel2, Grace Ji3, Shen Hu3, Linda Lopez1, Yingying Huang1

1. Thermo Fisher Scientific Inc., San Jose, CA
2. Cambridge Isotope Laboratories, Inc., MA
3. School of Dentistry and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA
 
 
Daniel Krug1,2, Carsten Volz1, Aiko Barsch3, Chris Beecher4, Felice de Jong4, Rolf Müller1,2
1. Helmholtz Institute for Pharmaceutical Research, Saarland (HIPS), Saarbrücken and Helmholtz Center for Infection Research (HZI), Braunschweig, Germany
2. Saarland University, Saarbrücken, Germany
3. Bruker Daltonik GmbH, Bremen, Germany
4. IROA Technologies, Ann Arbor, Michigan, USA
 
 

Bioprocess of a Yeast Fermentation Using the IROA Protocol

Chris Beecher and Felice de Jong
IROA Technologies LLC, Ann Arbor, MI, USA

 

Betaine Is as Effective as Folate at Re-synthesizing Methionine for Protein Synthesis During Moderate Methionine Deficiency in Piglets 

Laura E. McBreairty, Jason L. Robinson, Scott Harding, Edward Randell, Janet A. Brunton, Robert F. Bertolo 
 

The Impact of Dietary Methyl Donors on Whole-Body Methionine Partitioning in the Neonatal Piglet

Jason L. Robinson1, Laura E. McBreairty1, Scott V. Harding2, Janet A. Brunton1, Robert F. Bertolo1
1. Department of Biochemistry, Memorial University of Newfoundland, St. John’s, NL, Canada
2. Division of Nutrition Sciences, School of Medicine, Kings College London, London, UK
 
 
 

Isotopically Labeled Argininosuccinic Acid: A New Reference Standard for ASA

Adrienne Manning,1 William Wood,2 and Susan Henke2
1. Connecticut Department of Public Health Laboratory, Rocky Hill, CT
2. Cambridge Isotope Laboratories, Inc., Andover, MA
 
 
 

Breath Tests

Companion Diagnostic (CDx) for Personalizing Psychiatric Medications: Clinical Unmet Need

Anil Modak, PhD
Cambridge Isotope Laboratories, Inc. 3 Highwood Drive, Tewksbury, MA 01876 USA

 

Proteomics Mass Spectrometry Biomolecular NMR
Metabolic Research NMR Solvents and Consumables Standards for Environmental Analysis
Miscellaneous    

 

 

Mass Spectrometry

 

Amplatz, B.; et al. 2017. Bile acid preparation and comprehensive analysis by high performance liquid chromatography-high-resolution mass spectrometry. Clin Chim Act, 464, 85-92. PMID: 27838249

Wegner, K.; et al. 2017. Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria. Anal Bioanal Chem, 409(5), 1231-1245. PMID: 27822648

Sarafian, M.H.; et al. 2015. Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry. Anal Chem, 87(19), 9662-9670. PMID: 26327313

Han, J.; et al. 2015. Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phosopholipid-depletion solid-phase extraction. Anal Chem, 87(2), 1127-1136. PMID: 25496250

Gertsman, I.; et al. 2014. Validation of a dual LC-HRMS platform for clinical metabolic diagnosis in serum, bridging quantitative analysis and untargeted metabolomics. Metabolomics, 10(2), 312-323. PMID: 25411574

Suzuki, Y.; et al. 2013. Simple and rapid quantitation of 21 bile acids in rat serum and liver by UPLC-MS-MS: effect of high fat diet on glycine conjugates of rat bile acids. Nagoya J Med Sci, 75(1-2), 57-71. PMID: 23544269

Schrire, B.D.; et al. 2002. Indigofera mauritanica internal transcribed spacer 1, partial sequence; 5.8S ribosomal RNA gene, complete sequence; and internal transcribed spacer 2, partial sequence. Adv Legume Syst, 10. NCBI: AF521794.1

 

Proteomics 

 

Shwaiger, M.; Rampler, E.; Hermann, G.; et al. 2017. Anion-exchange chromatography coupled to high resolution mass spectrometry: a powerful tool for merging targeted and non-targeted metabolomics. Anal Chem, 89(14), 7667-7674. PMID: 28581703

Percy, A.J.; Byrns, S.; Pennington, S.R.; et al. 2016. Clinical translation of MS- based, quantitative plasma proteomics: status, challenges. Expert Rev Proteomics, 13(7), 673-684. PMID: 27341553 

Bao, X.R.; Ong, S.E.; Goldberger, O.; et al. 2016. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife, 16(5), e10575. PMID: 27307216 

McConnell, B.O.; Antoniewicz, M.R. 2016. Measuring the Composition and Stable-Isotope Labeling of Algal Biomass Carbohydrates via Gas Chromatography/Mass Spectrometry. Anal Chem, 88(9), 4624-4628. PMID: 27042946

Baughman, J.M.; Rose, C.M.; Koluman, G.; et al. 2016. NeuCode Proteomics Reveals Bap1 Regulation of Metabolism. Cell Rep,16(2), 583-595. PMID: 27373151

Geary, B.; Magee, K.; Cash, P.; et al. 2016. Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid. Proteomics, 16(9), 1398-1406. PMID: 26929125

Hecht, E.S.; McCord, J.P.; Muddiman, D.C. 2016. A Quantitative Glycomics and Proteomics Combined Purification Strategy. J Vis Exp, 8(109). PMID: 27023253

Baughman, JM; Rose, CM; Koluman, G. 2016. NeuCode Proteomics Revearls Bap1 Regulation of Metabolism. Cell Rep, 16(2), 583-595PMID: 27373151 

Singh, S.A.; Andraski, A.B.; Pieper, B.; et al. 2016. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res, 57(4), 714-728. PMID: 26862155

Henderson, C.M.; Vaisar, T.; Hoofnagle, A.N. 2016. Isolating and Quantifying Plasma HDL Proteins by Sequential Density Gradient Ultracentrifugation and Targeted Proteomics. Methods Mol Biol, 1410, 105-20. PMID: 26867741

Zhang, A.; Uaesoontrachoon, K.; Shaughnessy, C.; et al. 2015. The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse. Toxicol Rep, 838-849. PMID: 26213685

Wang, D.; Krilich, J.; Baudys, J.; et al. 2015. Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay. Anal Biochem, 468, 15-21. PMID: 25232998 

Cox, T.R.; Schoof, E.M.; Gartland, A.; et al. 2015. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data Brief, 5, 621-625. PMID: 26649326

Hecht, E.S.; Scholl, E.H.; Walker, S.H.; et al. 2015. Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples. J Proteome Res, 14(10), 4394-4401. PMID: 26347193

Mohammed, Y.; Percy, A.J.; Chambers, A.G.; et al. 2015. Qualis-SIS: automated standard curve generation and quality assessment for multiplexed targeted quantitative proteomic experiments with labeled standards.J Proteome Res. 14(2), 1137-1146. PMID: 25546269

Percy, A.J.; Mohammed, Y.; Yang, J.; et al. 2015. A Standard kit for automated quantitative assessment of candidate protein biomakers in human plasma. Bioanalysis, 7(23), 2991-3004. PMID: 26626236

Hecht, E.S.; McCord, J.P.; Muddiman, D.C. 2015. Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans. Anal Chem, 87(14), 7305-7312. PMID: 26086806
 

Murphy, J.P.; Everley, R.A.; Coloff, J.L.; et al. 2014. Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags. Anal Chem, 86(7), 3585-3593. PMID: 24611633

Hathout, Y.; Marathi, R.L.; Rayavarapu, S.; et al. 2014. Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. Hum Mol Genet, 23(24), 6458-6469. PMID: 25027324 

Edfors, F.; Bostrom, T.; Forsstrom, B.; et al. 2014. Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins. Mol Cell Proteomics, 13(6), 1611-1624. PMID: 24722731

Bagert, J.D.; Xie, Y.J.; Sweredoski, M.J.; et al. 2014. Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture. Mol Cell Proteomics, 13(5), 1352-1358. PMID: 24563536

McShane, A.J.; Bajrami, B.; Ramos, A.A.; et al. 2014. Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane. J Proteome Res, 13(11), 4676-4685. PMID: 25227318

Percy, A.J.; Chambers, A.G.; Yang, J.; et al. 2014. Advances in multiplexed MRM-based protein biomarker quantitation toward clinical utility. Biochim Biophys Acta, 1844(5), 917-926. PMID: 23806606

Adhikari, J.; Fitzgerald, M.C. 2014. SILAC-Pulse Proteolysis: A Mass Spectrometry-Based Method for Discovery and Cross-Validation in Proteome-Wide Studies of Ligand Binding. J Am Soc Mass Spectrom, 25(12), 2073-2083. PMID: 25315461

Percy, A.J.; Chambers, A.G.; Smith, D.S.; et al. 2013. Standardized protocols for quality control of MRM-based plasma proteomic workflows. J Proteome Res, 12(1), 222-233. PMID: 23245390

Zhang, C.; Liu, Y.; Andrews, P.C. 2013. Quantification of histone modifications using 15N metabolic labeling. Methods61(3), 236-243. PMID: 23454290

Hessling, B.; Buttner, K.; Hecker, M.; et al. 2013. Global relative quantification with liquid chromatography-matrix-assisted laser desorption ionization time-of-flight (LC-Maldi-TOF)-cross-validation with LTQ-Orbitrap proves reliability and reveals complementary ionization preferences. Mol Cell Proteomic, 12(10), 2911-2920. PMID: 23788530

Percy, A.J.; Chambers, A.G.; Yang, J.; et al. 2013. Method and platform standardization in MRM-based quantitative plasma proteomics. J Proteomics, 95, 66-76. PMID: 23933160

Chambers, A.G.; Percy, A.J.; Yang, J.; et al. 2013. Multiplexed quantitation of endogenous proteins in dried blood spots by multiple reaction monitoring-mass spectrometry. Mol Cell Proteomics, 12(3), 781-791. PMID: 23221968 

Butko, M.T.; Savas, J.N.; Friedman, B.; et al. 2013In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proc Natl Acad Sci, USA, 110(8), E726-E735. PMID: 23382246

Walker, S.H.; Taylor, A.D.; Muddiman, D.C. 2013. Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): A Novel Glycan- Relative Quantification Strategy. J Am Soc Mass Spectrom, 24, 1376-1384. PMID: 23860851
 

Hebert, A.S.; Merrill, A.E.; Bailey, D.J.; Still, A.J.; Westphall, M.S.; Strieter, E.R.; Pagliarini, D.J.; Coon, J.J. 2013. Neutron-encoded mass signatures for multiplexed proteome quantification. Nat Methods, 10(4), 332-334. PMID: 23435260

Rauniyar, N.; McClatchy, D.B.; Yates, J.R. III. 2013. Stable isotope labeling of mammals (SILAM) for in vivo quantitative proteomic analysis. Methods, 61(3), 260-268. PMID: 23523555

Rayavarapu, S.; Coley, W.; Cakir, E.; et al. 2013. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Mol Cell Proteomics. 12(5). 1061-1073. PMID: 23297347

Simon, G.M.; Cheng, J.; Gordon, J.I. 2012. Quantitative assessment of the impact of the gut microbiota on lysine ε-acetylation of host proteins using gnotobiotic mice. Proc Natl Acad Sci USA, 109, 11133-11138. PMID: 22733758

Dey, A.; Seshasayee, D.; Noubade, R.; et al. 2012. Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation. Science337(6101), 1541-1546. PMID: 22878500

Sharma, N.; Medikayala, S.; Defour, A.; et al. 2012. Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles. J Biol Chem, 287(36), 30455-30467. PMID: 22778268

Savas, J.N.; Toyama, B.H.; Xu, T.; et al. 2012. Extremely long-lived nuclear pore proteins in the rat brain. Science, 335(6071), 942. PMID: 22300851

Price, J.C.; Khambatta, C.F.; Li, K.W.; et al. 2012. The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics. Mol Cell Proteomics, 11(12), 1801-1814. PMID: 22984287

Walker, S.H.; Lilley, L.M.; Enamorado, M.F.; et al. 2011. Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry. J Am Soc Mass Spectrom, 22(8), 1309-1317. PMID: 21953184
 

Stergachis, A.; MacLean, B.; Lee, K.; et al. 2011. Rapid empirical discovery of optimal peptides for targeted proteomics. Nat Methods, 8(12), 1041-1043. PMID: 22056677

Hoofnagle A. 2010. Peptide Lost and Found: Internal Standards and the Mass Spectrometric Quantification of Peptides. Clin Chem, 56(10), 1515-1517. PMID: 20739635

Park, S.K.; Venable, J.D.; Xu, T.; et al. 2008. A quantitative analysis software tool for mass spectrometry-based proteomics. Nat Methods, 5(4), 319-322PMID: 18345006

McClatchy, D.B.; Yates, J.R. III. 2008. Stable Isotope Labeling of Mammals (SILAM). CSH Protoc, doi:10.1101/pdb.prot 4940. PMID: 21356771

Goshima, N.; Kawamura, Y.; Fukumoto, A.; et al. 2008. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nat Methods, 5(12), 1011-1017. PMID: 19054851

McClatchy, D.B.; Liao, L.; Park, S.K.; et al. 2007. Quantification of the synaptosomal proteome of the rat cerebellum during post-natal development. Genome Res, 17(9), 1378-1388. PMID: 17675365

McClatchy, D.B.; Dong, M.Q.; Wu, C.C.; et al. 200715N metabolic labeling of mammalian tissue with slow protein turnover. J. Proteome Res, 6(5), 2005-2010. PMID: 17375949

Mann, M. 2006. Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol, 7(12), 952-958. PMID: 17139335

Amanchy, R.; Kalume. D.E.; Pandey, A. 2005. Stable isotope labeling with amino acids in cell culture (SILAC) for studying dynamics of protein abundance and posttranslational modifications. Sci STKE, 267, 1-20. PMID: 15657263

Shadforth, I.P., et al. 2005. i-Tracker: for quantitative proteomics using iTRAQ®BMC Genomics, 6, 145. PMID: 16242023

MacCoss, M.J., et al. 2005. Measurement of the isotope enrichment of stable isotope-labeled proteins using high-resolution mass spectra of peptides. Anal Chem, 77(23), 7646-7653. PMID: 16316172

Kratchmarova, I.; Blagoev. B.; Haack-Sorensen. M.; et al. 2005. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science, 308(5727), 1472-1477. PMID: 15933201

Sadygov, R.; Cociorva, D.; Yates, J.R., III. 2004. Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book. Nat Methods, 1(13), 195-202. PMID: 15789030

Blagoev, B.; Ong, S.E.; Kratchmarova. I.; et al. 2004. Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nature Biotechnol, 22(9), 1139-1145. PMID: 15314609

Wu, C.C.; MacCoss, M.J.; Howell, K.E.; et al. 2004. Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem, 76(17), 4951-4959. PMID: 15373428

Ficarro, S.B., et al. 2002. Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiaeNat Biotechnol, 20(3), 301-305. PMID: 11875433

Ong, S.E.; Blagoev, B.; Kratchmarova, I.; et al. 2002. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics, 1(5), 376-386. PMID: 12118079

Goshe, M.B.; Conrads, T.P.; Panisko, E.A.; et al. 2001. Phosphoprotein isotope-coded affinity tag (PhIAT) approach for isolating and quantitating phosphopeptides in proteome-wide analyses. Anal Chem, 73(11), 2578-2586. PMID: 11403303

Conrads, T.P.; Alving, K.; Veenstra, T.D.; et al. 2001. Quantitative analysis of bacterial and mammalian proteomes using a combination of cysteine affinity tags and 15N-metabolic labeling. Anal Chem73(9), 2132–2139. PMID: 11354501

Washburn, M.P.; Wolters, D.; Yates, J.R., III. 2001. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat Biotechnol, 19(3), 242-247. PMID: 11231557

Pasa-Tolic, L.; Jensen, P.K.; Anderson, G.A.; et al. 1999. High throughput proteome-wide measurements of protein expression using mass spectrometry. J Am Chem Soc, 121(34), 7949-7950. JACS DOI:10.1021/ja991063o

Oda, Y.; Huang, K.; Cross, F.R.; et al. 1999. Accurate quantitation of protein expression and site-specific phosphorylation. Proc Natl Acad Sci USA, 96(12), 6591-6596. PMID: 10359756

Gygi, S.P.; Rist, B.; Gerber, S.A.; et al. 1999. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol, 17(10), 994-999. PMID: 10504701

Barlos, K.; Gatos. D. 1999. 9-Fluorenylmethyloxycarbonyl/tButyl-based convergent protein synthesis. Biopolymers, 51(4), 266-278. PMID: 10618595

Fujiwara, Y.; Akaji, K.; Kiso, Y. 1994. Racemization-Free Synthesis of C-Terminal Cysteine-Peptide Using 2-Chlorotrityl Resin. Chem Pharm Bull, 42(3), 724-726. PMID: 8004723

Barlos, K.; Gatos, D.; Kallitsis, J.; et al. 1989. Synthesis of Protected Peptide-Fragments Using Substituted Triphenylmethyl Resins. Tetrahedron Lett, 30, 3943-3946.

McNurlan, M.A.; Pain, V.M.; Garlick, P.J. 1980. Conditions that alter rates of tissue protein synthesis in vivoBiochem Soc Trans, 8(3), 283-285. PMID: 6772491

 

 

Metabolic Research

 

Geary, B.; Magee, K.; Cash, P.; et al. 2016. Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid. Proteomics, 16(9), 1398-1406. PMID: 26929125

Sellers, K.; Fox, M.; Bousamra, M.; et al. 2015. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest, 125(2), 687-698. PMID: 25607840

Buescher, J.; Antoniewicz, M.; Boros, L.; et al. 2015. A roadmap for interpreting 13C metabolite labeling patterns from cells. Curr Opin Biotechnol 34, 189-201. PMID: 25731751

Mayers, J.R., et al., 2014. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med, 20(10), 1193-1208. PMID: 25261994

Lewis, C., et al. 2014. Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells. Mol Cell, 55(2), 253-263. PMID: 24882210

Fan, J.; Ye, J.; Kamphorst, J.; et al. 2014. Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510(7504), 298-302. PMID: 24805240

Marini, J.C., et al. 2012. Arginine and Ornithine Are the Main Precursors for Citrulline Synthesis in Mice. J Nutrition, 142(3), 572-580. PMID: 22323761

 

Biomolecular NMR 

 

Harbers, M. 2014. Wheat germ systems for cell-free protein expression. FEBS Lett, 588(17), 2762-2773. PMID: 24931374

Sinnige, T.; Daniels, M.; Baldus, M.; et al. 2014. Proton Clouds to Measure Long-Range Contacts between Nonexchangeable Side Chain Protons in Solid-State NMR. J Am Chem Soc, 136(12), 4452-4455. PMID: 24467345

Weingarth, M.; Baldus., M. 2013.  Solid-State NMR-Based Approaches for Supramolecular Structure Elucidation. Acc Chem Res, 46(9), 2037-2046. PMID: 23586937

Loquet, A.; Habenstein, B.; Lange, A. 2013. Structural Investigations of Molecular Machines by Solid-State NMR. Acc Chem Res, 46(9), 2013-2079. PMID: 23496894

Verardi, R.; Traaseth, N.J.; Masterson, L. R.; et al. 2012. Isotope Labeling for Solution and Solid-State NMR Spectroscopy of Membrane Proteins. Adv Ex Med Bio, 992, 35-62. PMID: 23076578

Huber, M.; Hiller, S.; Schanda, P.; et al. 2012. A Proton-Detected 4D Solid-State NMR Experiment for Protein Structure Determination. Chem Phys Chem, 12(5), 915-918. PMID: 21442705

Park, S.H.; Das, B.B.; Casagrande. F.; et al. 2012. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature, 491(7426), 779-783. PMID: 23086146

Takeuchi, K.; Frueh, D.P.; Sun, Z.Y.; et al. 2010. HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment. J Biomol NMR, 49(1), 17-26. PMID: 21110064

Thakur, C.S.; Sama, J.N.; Jackson, M.E.; et al. 2010. Selective 13C labeling of nucleotides for large RNA NMR spectroscopy using an E. coli strain disabled in the TCA cycle. J Biomol NMR, 48(4), 179-192. PMID: 21057854

Wagner, G.; Lu, K.; Miyazaki, Y.; et al. 2010. A topical issue: production and labeling of biological macromolecules for NMR investigations J Biomol NMR, 46(1), 113-125. PMID: 19924385

Krishnarjuna, B.; Jaiupuria, G.; Thakur, A.D.; et al. 2010. Amino acid selective unlabeling for sequence specific resonance assignments in proteins. J Biomol NMR, 49(1), 38-51. PMID: 21153044

Zhu, J.; Ye, E.; Terskikh, V.; et al. 2010. Solid-state 17O NMR spectroscopy of large protein-ligand complexes. Angew Chem Int Ed, 49(45), 8399-8402. PMID: 20672261

Takahashi, H.; Shimada, I. 2010. Production of isotopically labeled heterologous proteins in non-E. coli prokaryotic and eukaryotic cells. J Biomol NMR, 46(1), 3-10. PMID: 19787297

Filipp, F.V.; Sinha, N.; Jairam, L.; et al. 2009. Labeling strategies for 13C-detected aligned-sample solid-state NMR of proteins. J Magn Reson, 201(2), 121-130. PMID: 19781966

Ayala, I.; Sounier, R.; Use, N.; et al. 2009. An efficient protocol for the complete incorporation of methyl-protonated alanine in perdeuterated protein. J Biomol NMR, 43(2), 111-119. PMID: 19115043

Wylie, B.J. 2009. Protein Structure Refinement Using 13Cα Chemical Shift Tensors. J Am Chem Soc, 131(3), 985-992. PMID: 19123862

Tong, K.I.; Yamamoto, M.; Tanaka, T. 2008. A simple method for amino acid selective isotope labeling of recombinant proteins in E. coli. J Biomol NMR, 42(1), 59-67. PMID: 18762866

Hiller, S.; Garces, R.G.; Malia, T.J.; et al. 2008. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science, 321(5893), 1206-1210. PMID: 18755977

Zhou, Y.; Cierpicki, T.; Jimenez, R.H.; et al. 2008. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell, 31(6), 896-908. PMID: 18922471

Takeuchi, K.; Ng, E.; Malia, T.J.; et al. 2007. 1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins. J Biomol NMR, 38(1), 89-98. PMID: 17390105

Isaacson, R.L.; Simpson, P.J.; Liu, M.; et al. 2007. A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues. J Am Chem Soc, 129(50), 15428-15429. PMID: 18041839

Kainosho, M.; Torizawa, T.; Iwashita, Y.; et al. 2006. Optimal isotope labeling for NMR protein structure determinations. Nature, 440(7080), 52-57. PMID: 16511487

Frueh, D.P.; Vosburg, D.A.; Walsh, C.T.; et al. 2006. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc, 128(17), 5757-5763. PMID:16637644

Chen, C.Y.; Cheng, C.H.; Chen, Y.C.; et al. 2006. Preparation of amino-acid-type selective isotope labeling of protein expressed in Pichia pastoris. Proteins, 62(1), 279-287. PMID: 16283643

Davis, J.H.; Tonelli, M.; Scott, L.G.; et al. 2005. RNA Helical packing in solution: NMR structure of a 30 kDa GAAA tetraloop-receptor complex. J Mol Biol, 351(2), 371-382. PMID: 16002091

Tugarinov, V.; Kay, L.E. 2005. Methyl groups as probes of structure and dynamics in NMR studies of high-molecular-weight proteins. Chembiochem, 6(9), 1567-1577. PMID: 16075427

Tyler, R.C.; Sreenath, H.K.; Singh, S.; et al. 2005. Auto-induction medium for the production of [U-15N]- and [U-13C, U-15N]-labeled proteins for NMR screening and structure determination. Protein Expr Purif, 40(2), 268-278. PMID: 15766868

Torizawa, T.; Shimizu, M.; Taoka, M.; et al. 2004. Efficient production of isotopically labeled proteins by cell-free synthesis: A practical protocol. J Biomol NMR, 30(3), 311-325. PMID: 15754057

Pickford, A.R.; O‘Leary, J.M. 2004. Isotopic labeling of recombinant proteins from the methylotrophic yeast Pichia pastoris. Methods Mol Biol, 278, 17-33. PMID: 15317988

Rodriguez-Mias, R.; Pellecchia, M. 2003. Use of Selective Trp Side Chain Labeling to Characterize Protein-Protein and Protein-Ligand Interactions by NMR Spectroscopy. J Am Chem Soc, 125(10), 2892-2893. PMID: 12617653

Castellani, F.; van Rossum, B.; Diehl, A.; et al. 2002. Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy. Nature, 420(6911), 98-102. PMID: 12422222

Hwang, P.M.; Choy, W.Y.; Lo, E.I.; et al. 2002. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci USA, 99(21), 13560-13565. PMID: 12357033

Rodriguez, E.; Krishna, N.R. 2001. An economical method for 15N / 13C isotopic labeling of proteins expressed in Pichia pastoris. J Biochem, 130(1), 19-22. PMID: 11432775

Cowburn, D. and Muir, T.W. 2001. Segmental isotopic labeling for structural biological applications of NMR. Methods Mol Biol, 278, 47–56. PMID: 15317990

Atreya, H.S.; Chary, K.V.R. 2001. Selective unlabeling of amino acids in fractionally 13C-labeled proteins: An approach for stereospecific NMR assignments of CH3 groups in Val and Leu residues. J Biomol NMR, 19(3), 267-272. PMID: 11330814

Morgan, W.D.; Kragt, A.; Feeney, J. 2000. Expression of deuterium-isotope-labeled protein in the yeast Pichia pastoris for NMR studies. J Biomol NMR, 17(4), 337-347. PMID: 11014598

Goto, N.K.; Gardner, K.H.; Mueller, G.A.; et al. 1999. A robust and cost-effective method for the production of Val, Leu, Ile (δ1) methyl-protonated 15N-, 13C-, 2H-labeled proteins. J Biomol NMR, 13(4), 369-374. PMID: 10383198

Wood, M.J.; Komives, E.A. 1999. Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation. J Biomol NMR, 13(2), 149-159. PMID: 10070756

Massou, S.; Puech, V.; Talmont, F.; et al. 1999. Heterologous expression of a deuterated membrane-integrated receptor and partial deuteration in methylotrophic yeasts. J Biomol NMR, 14(3), 231-239. PMID: 10481275

Hong, M. 1999. Determination of multiple phi-torsion angles in proteins by selective and extensive 13C labeling and two-dimensional solid-state NMR. J Magn Reson, 139(2), 389-401. PMID: 10423377

Gardner, K.H.; Kay, L.E. 1997. Production and Incorporation of 15N, 13C, 2H (1H δ1 methyl) Isoleucine into Proteins for Multidimensional NMR Studies. J Am Chem Soc, 119(32), 7599-7600. JACS DOI: 10.1021/ja9706514

Batey, R.T. 1996. Improved large-scale culture of Methylophilus methylotrophus for 13C / 15N labeling and random fractional deuteration of ribonucleotides. Nucleic Acids Res, 24(23), 4836-4837. PMID: 8972874

Vuister, G.W.; Kim, S.J.; Wu, C.; et al. 1994. 2D and 3D NMR study of phenylalanine residues in proteins by reverse isotopic labeling. J Am Chem Soc, 116(20), 9206-9210 JACS DOI:10.1021/ja00099a041

Ikura, M.; Kay, L.E.; Bax, A. 1990. A novel approach for sequential assignment of 1H, 13C, and 15N spectra of larger proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to Calmodulin. Biochemistry, 29(19), 4659-4667. PMID: 2372549

 

NMR Solvents and Consumables

 

Wei, H., et al. 2014. Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications. Drug Discov Today, 19(1), 95-102. PMID: 23928097

Singh, H.; Busenlehner, L.S. 2014. Probing backbone dynamics with hydrogen/deuterium exchange mass spectrometry. Methods Mol Biol, 1084, 81-99. PMID: 24061917

Shariatgorji, M.; Svenningsson, P.; Andrén, P.E. 2014. Mass spectrometry imaging, an emerging technology in neuropsychopharmacology. Neuropsychopharmacology 39(1), 34-49. PMID: 23966069

Tugarinov, V. 2014. Indirect use of deuterium in solution NMR studies of protein structure and hydrogen bonding. Prog Nucl Magn Reson Spectrosc, 77, 49-68. PMID: 24411830

Lam, W.W., et al. 2014. Metabolite Identification in Drug Discovery. Optim Drug Discovery, 445-459. Springer Link DOI: 10.1007/978-1-62703-742-6_26

Gronenberg, W., et al. 2014. Honeybees (Apis mellifera) learn to discriminate the smell of organic compounds from their respective deuterated isotopomers. Proc Biol Sci, 281(1778), 20133089. PMID: 24452031

Xu, G., et al. 2014. Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes. J Med Chem, 57(4), 1236-1251. PMID: 24456245

Williams, R.M.; Pang, S.H.; Medlin, J.W. 2014. OH versus CH bond scission sequence in ethanol decomposition on Pd (111). Surf Sci, 619,114-118. Science Direct DOI:10.1016/j.susc.2013.09.014

Sawadjoon, S., et al. 2014. Mechanistic Insights into the Pd‐Catalyzed Direct Amination of Allyl Alcohols: Evidence for an Outer‐sphere Mechanism Involving a Palladium Hydride Intermediate. Chemistry, 20(6), 1520-1524. PMID: 24403056

Gimeno, A., et al. 2014. Competitive Gold‐Activation Modes in Terminal Alkynes: An Experimental and Mechanistic Study. Chemistry, 20(3), 683-688. PMID: 24318565

Pal, S.; Zavalij, P.Y.; Vedernikov, A.N. 2014. Oxidative C (sp3)-H bond cleavage, C-C and C=C coupling at a boron center with O2 as the oxidant mediated by platinum (ii). Chem Commun, 50(40), 5376-5378. PMID: 24287586

Perkola, N.; Sainio, P. 2014. Quantification of four artificial sweeteners in Finnish surface waters with isotope dilution mass spectrometry. Environ Pollut, 184, 391-396. PMID: 24100049

White, S.J.; Jamie, I.M.; Angove, D.E. 2014. Chemical characterisation of semi-volatile and aerosol compounds from the photooxidation of toluene and NOX. Atmos Environ, 83, 237-244. Science Direct DOI:10.1016/j.atmosenv.2013.11.023

Shao, M., et al. 2014. The isotopic effects of deuteration on optoelectronic properties of conducting polymers. Nat Commun, 5, 3180. PMID: 24458188

Boillat, P., et al. 2014. Evaluation of Neutron Imaging for Measuring Phosphoric Acid Distribution in High Temperature PEFCs. J Electrochem Soc, 161(3), F192-F198. ECS DOI:10.1149/2.023403jes

Hirata, S., et al. 2014. Relationship between room temperature phosphorescence and deuteration position in a purely aromatic compound. Chem Phys Lett, 591, 119-125. Science Direct DOI: 10.1016/j.cplett.2013.11.019

Fulmer, G.R., et al. 2010. NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist. Organometallics, 29(9), 2176-2179. ACS DOI: 10.1021/om100106e

Kushner, D. J.; Baker, A.; Dunsta ll T.G. 1999. Pharmacological uses and perspectives of heavy water and deuterated compounds. Can J Physiol Pharmacol, 77(2), 79-88. PMID: 10535697

Gottlieb, H.E.; Kotlyar, V.; Nudelman, A. 1997. NMR chemical shifts of common laboratory solvents as trace impurities. J Org Chem, 62(21), 7512-7515. PMID: 11671879

 

Standards for Environmental Analysis

 

Zhang, Q.; Chen, Z.; Li, Y.; et al. 2015. Occurrence of organochlorine pesticides in the environmental matrices from King George Island, west Antarctica. Environ Pollut, 206, 142-149. PMID: 26162333

Liu, G.; Lv, P.; Jiang, X.; et al. 2015. Identification and preliminary evaluation of polychlorinated naphthalene emissions from hot dip galvanizing plants. Chemosphere, 118, 112-116. PMID: 25083943

Liu, G.; Lv, P.; Jiang, X.; et al. 2014. Identifying Iron Foundries as a New Source of Unintentional Polychlorinated Naphthalenes and Characterizing Their Emission Profiles. Environ Sci Technol, 48(22), 13165-13172. PMID: 25313855

Liu, G.; Liu, W.; Cai, Z.; et al. 2013. Concentrations, profiles, and emission factors of unintentionally produced persistent organic pollutants in fly ash from coking processes. J Hazard Mater, 261, 421-426. PMID: 23973475

Liu, G.; Zheng, M.; Du, B.; et al. 2012. Atmospheric emission of polychlorinated napthalenes from iron ore sintering processes. Chemosphere, 89(4); 467-472. PMID: 22739541

Liu, G.; Zheng, M.; Lv, P.; et al. 2010. Estimation and Characterization of Polychlorinated Naphthalene Emission from Coking Industries. Environ Sci Technol, 44(21), 8156-8161. PMID: 20886822

 

Miscellaneous
 

Metals

Hsu, W.H.; Jiang, S.J.; Sahayam, A.C. 2013. Determination of Cu, As, Hg and Pb in vegetable oils by elctrothermal vaporization inductively coupled plasma mass spectrometry with palladium nanoparticles as modifier. Talanta, 117, 268-272. PMID: 24209340

Busto, ME.; Montes-Bayon, M.; Sanz-Medel, A. 2006. Accurate determination of human serum transferrin isoforms: Exploring metal-specific isotope dilution analysis as a quantitative proteomic tool. Analytical Chemistry, 78(24), 8218-8226. PMID: 17165810

Chang, C.W.; Fennimore, A.M.; Afanasiev, A.; et al. 2006. Isotope efect on the thermal conductivity of boron nitride nanoubes. Phys Rev Lett, 97(8), 085901. PMID: 17026316

Encinar, J.R.; Villar, M.I.; Santamaria, V.G.; et al. 2001. Simultaneous determination of mono-, di-, and tributyltin in sediments by isotope dilution analysis using gas chromatography-ICPM. Anal Chem, 73(13), 3174-3180. PMID: 11467570

Matlock, M.M.; Howerton, B.S.; Atwood, D.A. 2001. Irreversible precipitation of mercury and lead. J Hazard Mater, 84(1), 73-82. PMID: 11376885

Compounds

Xu, J.; Zhu, P.; Gan, Z.; et al. 2010. Natural-abundance 43Ca solid-state NMR spectroscopy of bone. J Am Chem Soc, 132(33), 11504-11509. PMID: 20681578

Miwa, K.; Takano, J.; Fujiwara, T. 2006. Improvement of seed yields under boron-limiting conditions through overexpression of BOR1, a boron transporter for xylem loading, in Arabidopsis thaliana. Plant J, 46(6), 1084-1091. PMID: 16805739

Takano, J.; Miwa, K.; Yuan, L.; et al. 2005. Endocytosis and degradation of BOR1, a boron transporter of Arabidopsis thaliana, regulated by boron availability. Proc Natl Acad Sci U S A, 102(34),12276-12281. PMID: 16103374

Lee, K.H.; Liu, S.H.; Jiang, S.J. 1998. Determination of cadmium and lead in urine by electrothermal vaporization isotope dilution inductively coupled plasma mass spectrometry. Analyst,123(7), 1557-1560. PMID: 9830167

13C Breath Test Substrates 

Modak, A. 2017. Point-of-care companion diagnostic tests for personalizing psychiatric medications: Fulfilling an unmet clinical need. Journal of Breath Research.  JBR

Pan, W.; Wang, Z.; Tian, F.; et al. 2017. Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis. Exp Ther Med, 12(4), 1637-1643. PMID: 28413522

Gorowska-Kowolik, K.; Chobot, A.; Kwiecien, J. 2017. 13C Methacetin Breath Test for Assessment for Microsomal Liver Function: Methodology and Clinical Application. Gastroenterol Res Pract, 2017. PMID: 28757868

Franken, J.; Mauritz, F.A.; Stellato, R.K.; et. al. 2017. The Effect of Gastrostomy Placement on Gastric Function in Children: a Prospective Cohort Study. J Gastrointest Surg, 21(7), 1105-1111. PMID: 28424983

Moran, S.; Duque, X.; Xochiquetzal Ortiz-Olvera, N. et al. 2017. Utility of 13C-methacetin breath test in predicting long-term survival of patients with decompensated cirrhosis. Journal of Breath Research. PMID: 28649974

Caviglia, GP.; Sguazzini, C.; Cisaro, F. et al. 2017 . Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test. Edizioni Minerva Medica. PMID: 28707862

Modak, A. 2017. Point-of-care companion diagnostic tests for personalizing psychiatric medications: fulfilling an unmet clinical need. J. Breath Res. 017101. PMID: 28920579

Rubin, T.; Heyne, K.; Luchterhand, A. et al. 2017. Kinetic validation of the LiMAx test during 10,000 intravenous 13C-methacetin breath tests. J. Breath Res. 016005. PMID: 28742055

Moran, S.; Mina, A.; Duque, X. et al. 2017. The utility of the 13C-methacetin breath test in predicting the long-term survival of patients with decompensated cirrhosis. J. Breath Res. 036011. PMID: 28649974

Matsumoto H.; Shiotani A.; Katsumata, R.; et al. 2016. Helicobacter pylori Eradication with Proton Pump Inhibitors or Potassium-Competitive Acid Blockers: The Effect of Clarithromycin Resistance. Dig Dis Sci, 61 (11), 3215-3220. NCBI

Maldonado-Hernandez, J et al. 2016. The 13C-Glucose Breath Test for Insulin Resistance Assessment in Adolescents: Comparison with Fasting and Post-Glucose Stimulus Surrogate Markers of Insulin Resistance. J Clin Res, 8(4), 419-424. NCBI

Modak, A.S.; Klyarytska, I.; Kriviy, V.; et al. 2016. The effect of proton pump inhibitors on the CYP2C19 enzyme activity evaluated by the pantoprazole-13C breath test in GERD patients: clinical relevance for personalized medicine. J Breath Res, 10(4), 046017. PMID: 27991432

Harvey, A.; Modak, A.; Dery, U.; et al. 2016. Changes in CYP2C19 enzyme activity evaluated by the [(13)C]-pantoprazole breath test after co-administration of clopidogrel and proton pump inhibitors following percutaneous coronary intervention and correlation to platelet reactivity. J Breath Res, 10(1), 017104. PMID: 26815196

Furnari, M.; Ahmed, I.; Erpecum, K.J.; et. al. 2016. Breath Tests in Assess Alcoholic Liver Disease. Rev Recent Clin Trials, 11(3), 185-190. PMID: 27515960

Kempinski, R.; Neubaur, K.; Wieczorek, S.; et. al. 2016. 13C-Methacetin Breath Testing in Patients with Non-Alcoholic Fatty Liver Disease. Adv Clin Exp Med, 25(1), 77-81. PMID: 26935501

Jara, M.; Bednarsch, J.; Malinowski, M.; et. al. 2016. Effects of oxaliplatin-based chemotherapy on liver function--an analysis of impact and functional recovery using the LiMAx test. Langenbecks Arch Surg, 401(1), 33-41. PMID: 26507639

Siddiqui, I.; Ahmed, S.; Abid, S. 2016. Update on diagnostic value of breath test in gastrointestinal and liver diseases. World J Gastrointest Pathophysiol, 7(3), 256-265. PMID: 27574563.

Chapman, M.J.; Deane, A.M.; O'Connor, S.L.; et al. 2016. The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial. Crit Care, 20(1), 232. PMID: 27476581

Usai-Satta, P.; Oppia, F.; Scarpa, M.; et al. 2016. Delayed gastric emptying does not normalize after gluten withdrawal in adult celiac disease. Scand J Gastroenterol, 51(8), 923-926. PMID: 27161492

Hauser, B.; Roelants, M.; De Schepper, J.; et al. 2016. Gastric emptying of solids in children: reference values for the (13) C-octanoic. Neurogastroenterol Motil, 28(10), 1480-1487. PMID: 27098977

Horner, K.M.; Finlayson, G.; Byrne, N.M.; et al. 2016. Food reward in active compared to inactive men: Roles for gastric emptying and body fat. Physiol Behav, 160, 43-49. PMID: 27072508
Maldonado-Hernandez, J et al. 2016. The 13C-Glucose Breath Test for Insulin Resistance Assessment in Adolescents: Comparision with Fasting and Post-Glucose Stimulus Surrogate Markers of Insulin Resistance. J Clin Res Prediatr Endocrinol, 8(4), 419-424. PMID: 27354200

Tack, J.; Rotondo, A.; Meulemans, A.; et al. 2016. Randomized clinical trial: a controlled pilot trial of the 5-HT4 receptor agonist revexepride in patients with symptoms suggestive of gastroparesis. Neurogastroenterol Motil, 28(4), 487-497. PMID: 27010235

Hellstrom, P.M.; Tack, J.; Johnson, L.V.; et al. 2016. The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying. Br J Pharmacol, 173(11), 1768-1777. PMID: 26924243.

Thazhath, S.S.; Wu, T.; Bound, M.J.; et al. 2016. Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial. Am J Clin Nutr, 103(1), 66-70. PMID: 26607942.

Opdam, F.L.; Modak, A.S.; Gelderblom, H.; et al. 2015. Further characterization of a 13C-dextromethorphan breath test for CYP2D6 phenotyping in breast cancer patients on tamoxifen therapy. J Breath Res, 9(2), 026003. PMID:25891764

Opdam, F.L.; Modak, A.S.; Mooijaart, S.P.; et al. 2015. CYP2D6 Metabolism in Frail Elderly Compared to Non-Frail Elderly: A Pilot Feasibility Study. Drugs & Aging. 32(12), 1019-1027PMID: 26597400

Safgren, S.L.; Suman, V.J.; Kosel, M.L.; et al. 2015. Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen. Pharmacogenet Genomics, 25(4), 157-163. PMID: 25714002

Stravitz, R.T.; Reuben, A.; Mizrahi, M.; et. al. 2015. Use of the methacetin breath test to classify the risk of cirrhotic complications and mortality in patients evaluated/listed for liver transplantation. J Hepatol, 63(6), 1345-1351. PMID: 26220750.

Jara, M.; Bednarsch, J.; Valle, E.; et al. 2015. Reliable assessment of liver function using LiMAx. J Surg Res, 193(1), 184-189. PMID: 25150081

Meyer, R.; Foong, R.X.; Thapar, N.; et al. 2015. Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children. BMC Gastroenterol, 15, 137. PMID: 26472544    

Epprecht, L.; Schreglmann, S.R.; Goetze, O.; et. al. 2015. Unchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal. J Neurol, 262(8), 1946-1953. PMID: 26048686. 

Horner, K.M.; Byrne, N.M.; Cleghorn, G.J.; et al. 2015. Influence of habitual physical activity on gastric emptying in healthy males and relationships with body composition and energy expenditure. Br J Nutr, 114(3), 489-496 PMID: 26168984.

Gourcerol, G.; Tissier, F.; Melchior, C.; et al. 2015. Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation. Aliment Pharmacol Ther, 41(4), 360-367. PMID: 25523288

Bonfrate, L.; Grattagliano, I.; Palasciano, G.; et al. 2015. Dynamic carbon 13 breath tests for the study of liver function and gastric emptying. Gastroenterol Rep, 3(1), 12-21. PMID: 25339354

Grattagliano, I.; Bonfrate, L.; Lorusso, M.; et al. 2015. Exploring liver mitochondrial function by 13C-stable isotope breath tests: implications in clinical biochemistry. Methods Mol Biol, 1241, 137-152. PMID: 25308494.

Hijaz, N.M.; Friesen, C.A.; Schuman, J.V.; et al. 2015. Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post-prandial distress syndrome. Neurogastroenterol Motil, 27(8), 1120-1126. PMID: 25962328.

Hersch, M.; Krasilnikov, V.; Helviz, Y.; et al. 2015. Prokinetic drugs for gastric emptying in critically ill ventilated patients: Analysis through breath testing. J Crit Care, 30(3), 655.e7-13. PMID: 25746849.

Klieber, M.; Oberacher, H.; Hofstaetter, S. et al. 2015. Phenoconversion by Routinely Prescribed Proton Pump Inhibitors Omeprazole and Esomeprazole: Clinical Implications for Personalized Medicine.Journal of Pharmacology and Experimental Therapeutics.  354 (3) 426-430. ASPET

Hussain M. et al. 2014. [13C]Glucose Breath Testing Provides a Noninvasive Measure of Insulin Resistance: Calibration Analyses Against Clamp Studies. Diabetes Technology & Therapeutics.16. 2. NCBI

Konstantinou, D.; Margariti, K; Hadziyannis, E.; et al. 2014. Significance of the 13C-caffeine breath test for patients with cirrhosis. Annals of Gastroenterology 27,53-59. NCBI.

Adhikari, J.; Fitzgerald, M.C. 2014  SILAC-Pulse Proteolysis: A Mass Spectrometry-Based Method for Discovery and Cross-Validation in Proteome-Wide Studies of Ligand Binding. J Am Soc Mass Spectrom, 25(12), 2073-2083. PMID: 25315461

Fierbinteanu-Braticevici, C.; Papacocea, R.; Tribus, L.; et al 2014. Role of 13C methacetin breath test for non invasive staging of liver fibrosis in patients with chronic hepatitis C. Indian J Med Res, 140(1), 123-129. PMID: 25222787.

Thazhath, S.S.; Wu, T.; Bound, M.J.; et al. 2014. Changes in meal composition and duration affect postprandial endothelial function in healthy humans. Am J Physiol Gastrointest Liver Physiol, 307(12), G1191-G1197. PMID: 25342049 

Horner, K.M.; Byrne, N.M.; Cleghorn, G.J.; et. al. 2014. Reproducibility of gastric emptying in overweight and obese males. Clin Nutr, 33(4), 684-688. PMID: 24074547

Kawamura, M.; Nakada, K.; Konishi, H.; et al. 2014. Assessment of motor function of the remnant stomach by 13C breath test with special reference to gastric local resection. World J Surg, 38(11), 2898-28903. PMID: 24934641.

Kasicka-Jonderko, A.; Jonderko, K.; Gajek, E.; et al. 2014. Sluggish gallbladder emptying and gastrointestinal transit after intake of common alcoholic beverages. J Physiol Pharmacol, 65(1), 55-66. PMID: 24622830.

Clegg, M.E.; Shafat, A. 2014. The effect of agar jelly on energy expenditure, appetite, gastric emptying and glycaemic response. Eur J Nutr, 53(2), 533-539. PMID: 23872837.

Maldonado-Hernandez, J.; Prina-Ojeda., L.; Montalvo-Velarde. et al. 2014 . Validity and reliability of the 13C-methionine breath test for the detection of moderate hyperhomocysteinemia in Mexican adults. 52(5). PMID: 24607920

Modak, A.S. 2013. Regulatory issues on breath tests and updates of recent advances on [13C]-breath tests. J Breath Res, 7(3), 037103. PMID: 23774086 

Opdam, F.L.; Modak, A.S.; Gelderblom, H. et al. 2013. Breath tests to phenotype drug disposition in oncology. Clin Pharmacokinet, 52(11), 919-926. PMID: 23868281  

Opdam, F.L.; Dezentje, V.O.; den Hartigh, J.; et al. 2013. The use of the 13C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels. Cancer Chemother Pharmacol, 71(3), 593-601. PMID: 23228987

Thacker, D.L.; Modak, A.; Flockhart, D.A.; et al. 2013. Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? J Breath Res, 7(1), 016001. PMID: 23257668

Cunha-Junior, G.F.; De Marco, L.; Bastos-Rodrigues, L.; et. al. 2013. (13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients. Cancer Chemother Pharmacol, 72(6), 1273-1282. PMID: 24101147.

Fierbinteanu-Braticevici, C.; Plesca, D.A.; Tribus, L.; et al. 2013. The role of 13C-methacetin breath test for the non-invasive evaluation of nonalcoholic fatty liver disease. J Gastrointestin Liver Dis, 22(2), 149-156. PMID: 23799213.

Holzhutter, H.G.; Lock, J.F.; Taheri, P.; et. al. 2013. Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)C-methacetin breath test. PLoS One, 8(8), e70780. PMID: 23967104.

Kochel-Jankowska, A.; Hartleb, M.; Jonderko, K.; et. al. 2013. 13C-methacetin breath test correlates with clinical indices of liver disease severity in patients with primary biliary cirrhosis. J Physiol Pharmacol, 64(1), 27-33. PMID: 23568968

Vranova, J.; Hendrichova, M.; Kolarova, H.; et al. 2013. 13C-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 157(4), 392-400. PMID: 23549507   

Kasicka-Jonderko, A.; Jonderko, K.; Budniok, M.; et al. 2013. Comparison of two dosage regimens of the substrate for the [13C]methacetin breat test. Isotopes Environ Health Stud, 49(1), 109-121. PMID: 22827182

Shteyer, E.; Lalazar, G.; Hemed, N.; et. al. 2013. Continuous 13C-methacetin breath test differentiates biliary atresia from other causes of neonatal cholestasis. J Pediatr Gastroenterol Nutr, 56(1), 60-65. PMID: 22695040

Bruno, G.; Lopetuso, L.R.; Laniro, G.; et al. 2013. 13C-octanoic acid breath test to study gastric emptying time. Eur Rev Med Pharmacol Sci, 17, 59-64. PMID: 24443070

Salles Junior, L.D.; Santos, P.R.; dos Santos, A.A.; et al. 2013. Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis. BMC Nephrol, 14, 275. PMID: 24330675

Gourcerol, G.; Benanni, Y.; Boueyre, R.; et al. 2013. Influence of gastric emptying on gastro-esophageal reflux: a combined pH-impedance study. Neurogastroenterol Motil, 25(10), 800-e634. PMID: 23848571

Lorenz, M.; Pfeiffer, C.; Steinstrasser, A.; et al. 2013. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes-relationship to postprandial glycemia. Regul Pept, 185, 1-8. PMID: 23665027

Nguyen, N.Q.; Bryant, L.K.; Burgstad, C.M.; et al. 2013. Gastric emptying measurement of liquid nutrients using the (13)C-octanoate breath test in critically ill patients: a comparison with scintigraphy. Intensive Care Med, 39(7), 1238-1246. PMID: 23471513.

Dickman, R.; Zilper, T.; Steinmetz, A.; et al. 2013. Comparison of continuous breath test and gastric scintigraphy for the measurement of gastric emptying rate in healthy and dyspeptic individuals. Eur J Gastroenterol Hepatol, 25(3), 291-295. PMID: 23354159

Clegg, M.E.; Ranawana, V.; Shafat, A.; et al. 2013. Soups increase satiety through delayed gastric emptying yet increased glycaemic response. Eur J Clin Nutr, 67(1), 8-11. PMID: 23093339.

Modak, A.; Durso, R.; Josephs, E.; Rosen, D. 2012. A rapid non invasive L-DOPA-¹³C breath test for optimally suppressing extracerebral AADC enzyme activity - toward individualizing carbidopa therapy in Parkinson’s disease. J Parkinsons Dis, 2(4), 349-356. PMID: 23646099

Modak, A.S. 2012. Phenotype Breath Tests as Companion Diagnostic Tests (CDx) in Clinical Trials of Drugs. J Pharmacogenomics Pharmacoproteomics. 3(1), (2pp). http://www.omicsonline.org

Higashida, M.; Matsumoto, H.; Kubota, H.; et. al. 2012. Evaluation of 5-FU plasma concentration by 13C breath test in patients treated with oral 5-FU analogs. Anticancer Res, 32(12), 5407-5414. PMID: 23225444

Ishii, Y.; Suzuki, S.; Asai, S.; et al. 2012. Liver function assessment with three (13)C breath tests by two-point measurements. Isotopes Environ Health Stud, 48(4), 543-557. PMID: 22540278

Nobrega, A.C.; Ferreira, B.R.; Oliveira, G.J.; et al. 2012. Dyspeptic symptoms and delayed gastric emptying of solids in patients with inactive Crohn's disease. BMC Gastroenterol, 12, 175. PMID: 23216812

Doi, H.; Sakakibara, R.; Sato, M.; et al. 2012. Plasma levodopa peak delay and impaired gastric emptying in Parkinson's disease. J Neurol Sci, 319(1-2), 86-88. PMID: 22632782.

Hoffman, I.; Tack, J. 2012. Assessment of gastric motor function in childhood functional dyspepsia and obesity. Neurogastroenterol Motil, 24(2), 108-112. PMID: 22103293

Modak, A.S. 2011. Barriers to overcome for transition of breath tests from research to routine clinical practice. J Breath Res, 5(3), 030202. PMID: 21900729 

Thacker, D.L.; Modak, A.; Nguyen, P.D.; et al. 2011. Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity. Chirality, 23(10), 904-909. PMID: 21935988

Kasicka-Jonderko, A.; Nita, A.; Jonderko, K.; et al. 2011. C-methacetin breath test reproductivity study reveals persistent CyP1A2. World J Gastroenterol, 17(45), 4979-4986. PMID: 22174547.

Razlan, H.; Marzuki, N.M.; Tai, M.L.; et al. 2011. Diagnostic value of the C methacetin breath test in various stages of chronic liver disease. Gastroenterol Res Pract, 2011, 235796. PMID: 21687605.

Kasicka-Jonderko, A.; Loska, D.; Jonderko, K.; et al. 2011. Interference of acute cigarette smoking with [13C]methacetin breath test. Isotopes Environ Health Stud, 47(1), 34-41. PMID: 21287423.

Ron, Y.; Sperber, A.D.; Levine, A.; et. al. 2011. Early satiety is the only patient-reported symptom associated with delayed gastric emptying, as assessed by breath-test. J Neurogastroenterol Motil, 17(1), 61-66. PMID: 21369493

Hope, H.B.; Medhus, A.W.; Sandstad, O.; et al. 2011. Reduced 13C-D-xylose absorption in alcoholics is more likely caused by alterations in small intestinal mucosa than delayed gastric emptying. Scand J Gastroenterol, 46(4), 414-419. PMID: 21275757

Janssen, P.; Van Oudenhove, L.; Casteels, C.; et al. 2011. The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers. Aliment Pharmacol Ther, 33(3), 395-402. PMID: 21118281. 

Bluck, L.J.; Jackson, S.J.; Vlasakakis, G.; et al. 2011. Bayesian hierarchical methods to interpret the (13)C-octanoic acid breath test for gastric emptying. Digestion, 83(1-2), 96-107. PMID: 21042021

Dickman, R.; Steinmetz, A.; Bernnstine, H.; et al. 2011. A novel continuous breath test verus scintigraphy for gastric emptying rate measurement. J Clin Gastroenterol, 45(1), 22-25. PMID: 20495467. 

Ranawana, V.; Clegg, M.E.; Shafat, A; et al. 2011. Postmastication digestion factors influence glycemic variability in humans. Nutr Res, 31(6), 452-459. PMID: 21745627.

Banasch, M.; Ellrichmann, M.; Tannapfel, A. et al. 2011. The Non-Invasive 13C-Methionine Breath Test Detects Hepatic Mitochondrial Dysfunction As a Marker of Disease Activity In Non-Alcoholic Steatohepatitis. Eur J Med Res. 258-264. PMID: PMC3353401

Modak, A.S. 2010. Breath biomarkers for personalized medicine. Personalized Medicine, 7(6), 640-651Future Medicine

Modak, A.S. 2010. Single time point diagnostic breath tests: a review. J Breath Res, 4(1), 017002. PMID: 21386204 

Ishii, Y.; Suzuki, S.; Takahashi, Y.; et al. 2010. Can the 2-(13)C-uracil breath test be used to predict the effect of the antitumor drug S-1? Cancer Chemother Pharmacol, 66(2), 333-343. PMID: 19921195

Azulay, D.O.; Stunder, D.; Wilson, F. 2010. Stochastic simulations of the exponential-beta function as an assessment of the validity of the choice of the Wagner-Nelson method for the analysis of 13C-octanoic acid breath tests. J Breath Res, 4(3), 036001. PMID: 21383478 

Sfarti, C.; Trifan, A.; Hutanasu, C.; et al. 2010. Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. J Gastrointestin Liver Dis,19(3), 279-284. PMID: 20922192.

Grattagliano, I.; Lauterburg, B.H.; Palasciano, G.; et al. 2010. 13C-breath tests for clinical investigation of liver mitochondrial function. Eur J Clin Invest, 40(9), 843-850. PMID: 20597965

Clegg, M.E.; Shafat, A. 2010. Procedures in the 13C Octanoic breath test for measurement of gastric emptying: analysis using Bland-Altman methods. Scand J Gastroenterol, 45(7-8), 852-861. PMID: 20443742.

Perri, F.; Bellini, M.; Portincasa, P.; et al. 2010. (13)C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer): Toward standardization for testing gastric emptying of solids. Dig Liver Dis, 42(8), 549-553. PMID: 20116352.

Duro, D.; Fitzgibbons, S.; Valim, C. et al. 2010. [13C]Methionine Breath Test to Assess Intestinal Failure-Associated Liver Disease. Pediatr Res. 68(4)-349-354. PMID: 20581744

Ezzeldin, H.H.; Acosta, E.P.; Mattison, L.K.; et al. 2009. (13)C-5-FU breath test current status and future directions: a comprehensive review. J Breath Res, 3(4), 047002. PMID: 21386199

Modak, A.S. 2009. 13C breath tests in personalized medicine: fiction or reality? Expert Review of Molecular Diagnostics, 9(8), 805-815Tandfonline

Modak, A.S. 2009. Rapid identification of hepatic CYP2C19 activity using a novel and non-invasive [13C]-pantoprazole breath test. Journal of Pharmacology and Experimental Therapeutics, 329(1), 297-305.

Lalazar, G.; IIan, Y. 2009. Assessment of liver function in acute or chronic liver disease by the methacetin breath test: a tool for decision making in clinical hepatology. J Breath Res,  3(4), 047001. PMID: 21386198

Lalazar, G.; Adar, T.; IIan, Y. 2009. Point-of-care continuous (13)C-methacetin breath test improves decision making in acute liver disease: results of a pilot clinical trial. World J Gastroenterol, 15(8), 966-972. PMID: 19248196.

Mawatari, H.; Inamori, M.; Yoneda, M.; et al. 2009. The continuous real-time 13C-octanoate breath test for patients with nonalcoholic steatohepatitis using the BreathID system. Hepatogastroenterology, 56(94-95),1436-1438. PMID: 19950806.

Verbeke, K. 2009. Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying? Neurogastroenterol Motil, 21(10), 1013-1016. PMID: 19737258.

Keller, J.; Andresen, V.; Wolter, J.; et al. 2009. Influence of clinical parameters on the results of 13C-octanoic acid breath tests: examination of different mathematical models in a large patient cohort. Neurogastroenterol Motil, 21(10), 1039-e83. PMID: 19549136.

Braden, B.; Caspary, W.; Borner, N.; et al. 2009. Clinical effects of STW 5 (Iberogast) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis. Neurogastroenterol Motil, 21(6), 632-638, e25. PMID: 19220753.

Duro, D.; Duggan, C. Valim, C. et al. 2009 . Novel intravenous 13C-methionine breath test as a measure of liver function in children with short bowel syndrome. J Pediatr Surg. 44(1):236-240.  PMID: 19159749

Modak, A.S. 2008. Diagnostic breath tests in personalized medicine. Expert Rev Mol Diagn, 8(5), 563-564. Tandfonline

Leeder, J.S.; Pearce, R.E.; Gaedigk, A.; et al. 2008. Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype. J Clin Pharmacol, 48(9), 1041-1051. PMID: 18728242

Lalazar, G.; Pappo, O.; Hershcovici, T.; et. al. 2008. A continuous 13C methacetin breath test for noninvasive assessment of intrahepatic inflammation and fibrosis in patients with chronic HCV infection and normal ALT. J Viral Hepat, 15(10), 716-728. PMID: 18638013.

Wutzke, K.; Forberger, A.; Wigger, M. 2008. Effect of alcohol consumption on the liver detoxication capacity as measured by [13C]methacetin- and [methyl-13C]methionine-breath tests. Isotopes in Environmental and Health Studies, 44(2), 219-226. Taylor Francis Online.

Dinesen, L.; Caspary, W.F.; Chapman, R.W. et al. 2008. 13C-methacetin-breath test compared to also noninvasive biochemical blood tests in predicting hepatic fibrosis and cirrhosis in chronic hepatitis C. Dig Liver Dis, 40(9), 743-748. PMID: 18339592.

Pacilli, M.; Pierro, A.; Lindley, K.J.; et al. 2008. Gastric emptying is accelerated following laparoscopic Nissen fundoplication. Eur J Pediatr Surg, 18(6), 395-397. PMID: 19039735.

Kocelak, P.; Zahorska-Markiewicz, B.; Jonderko, K.; et al. 2008. Long-term effects of lipase inhibition by orlistat on gastric emptying and orocecal transit time of a solid meal. J Gastroenterol, 43(8), 609-617. PMID: 18709483.

Vignolo, M.C.; Savassi-Rocha, P.R.; Coehlo, L.G.; et al. 2008. Gastric emptying before and after cholecystectomy in patients with cholecystolithiasis. Hepatogastroenterology, 55(84), 850-854. PMID: 18705281.

Choung, R.S.; Cremonini, F.; Thapa, P.; et al. 2008. The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric empyting: a double-blind, randomized, placebo-controlled trial. Neurogastroenterol Motil, 20(3), 220-227. PMID: 18031471.

Candelli, M.; Miele, L.; Armuzzi. et al. 2008.13C-methionine breath tests for mitochondrial liver function assessment.  European Review for Medical and Pharmacological Sciences. 12:245-249. PMID: 18727456

Freeman, R.B.; Dixon, M.; Horth, B.; et al. 2007. L-[1-(13)C] phenylalanine breath test for monitoring hepatic function after living donor liver transplant surgery. J Breath Res, 1(2), 026002. PMID: 21383436

Modak, A.S. 2007. Stable isotope breath tests in clinical medicine: a review. J Breath Res, 1(1), 014003. PMID: 21383429

Modak, A.S. 2007. Phenotype breath tests for personalized medicine. J Labelled Comp Radiopharm, 50(5-6), 571-573. Online Library.

Modak, A.S.; Reid. J.M.; Williams, L.A.; et al. 2007. A simple non-invasive method to detect and monitor hypercapnia: the sodium [13C]bicarbonate breath test. Isotopes Environ Health Stud, 43(1), 23-29. PMID: 17454270

IIan, Y. 2007. Review article: the assessment of liver function using breath tests. Aliment Pharmacol Ther, 26(10), 1293-1302. PMID: 17868431.

Goetze, O.; Selzner, N.; Fruehauf, H.; et al. 2007. 13C-methacetin breath test as a quantitative liver function test in patients with chronic hepatitis C infection: continuous automatic molecular correlation spectroscopy compared to isotopic ratio mass spectrometry. Aliment Pharmacol Ther, 26(2), 305-311. PMID: 17593076

Schneider, A.; Caspary, W.F.; Saich, R.; et al. 2007. 13C-methacetin breath test shortened: 2-point-measurements after 15 minutes reliably indicate the presence of liver cirrhosis. J Clin Gastroenterol, 41(1), 33-37. PMID: 17198062

Hoffman, I.; Tertychnyy, A.; Ectors, N.; et al. 2007. Duodenogastro-esophageal reflux in children with refractory gastro-esophageal reflux disease. J Pediatr, 151(3), 307-311. PMID: 17719945.

Matsumoto, M.; Yoshimura, R.; Akiho, H.; et al. 2007. Gastric emptying in diabetic patients by the (13)C-octanoic acid breath test: role of insulin in gastric motility. J Gastroenterol, 42(6), 469-474. PMID: 17671762.

Cardoso-Junior, A.; Coehlo, L.G.; Savassi-Rocha, P.R.; et al. 2007. Gastric emptying of solids and semi-solids in morbidly obese and non-obese subjects: an assessment using the 13C-octanoic acid and 13C-acetic acid breath tests. Obes Surg, 17(2), 236-241. PMID: 17476878.

Modak, A.S. 2006. Racial Differences in Dihydropyrimidine Dehydrogenase Activity: Increased Prevalence of DPD Deficiency in African Americans Compared to Caucasians. Clin Cancer Res, 12, 5491-5495.

Mattison, L.K.; Fourie, J.; Hirao, Y.; et al. 2006. The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 plasma [2-13C] dihydrouracil. Clin Cancer Res, 12(2), 549-555. PMID: 16428499

Saif, M.W.; Mattison, L.; Carollo, T.; et. al. 2006. Dihydropyrimidine dehydrogenase deficiency in an Indian population. Cancer Chemother Pharmacol, 58(3), 396-401. PMID: 16421754

Holtmeier, J.; Leuschner, M.; Schneider, A.; et al. 2006. 13C-methacetin and 13C-galactose breath tests can assess restricted liver function even in early stages of primary biliary cirrhosis. Scand J Gastroenterol, 41(11), 1336-1341. PMID: 17060128

Eradi, B.; Wright, J.; Gibbons, N.J.; et al. 2006. Validity of 13C octanoic acid breath test for measurement of solid meal gastric emptying time in children. J Pediatr Surg, 41(12), 2062-2065. PMID: 17161206.

Hellmig, S.; Von Schoning, F.; Gadow, C.; et al. 2006. Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass index. J Gastroenterol Hepatol, 21(12), 1832-1838. PMID: 17074022.

Tack, J.; Coulie, B.; Verbeke, K.; et al. 2006. Influence of delaying gastric emptying on meal-related symptoms in healthy subjects. Aliment Pharmacol Ther, 24(7), 1045-1050. PMID: 16984498.

Banasch, M.; Goetze, O.; Hollborn, I. et al.2006. 13C-Methionine Breath Test Detects Distinct Hepatic Mitochondrial Dysfunction in HIV-Infected Patients With Normal Serum Lactate. J Acquir Immune Defic Syndr. 40:149-154. PMID: 16186731

Milazzo, L.; Menzaghi, B.; Massetto, B. et al. 2006. 13C-methionine breath test detects drug-related hepatic mitchondrial dysfunction in HIV-infected patients. Journal Acquir Immune Defic Syndr. (2):252-3. PMID: 16394861

Braden, B.; Faust, D.; Sarrazin, U.; et al. 2005.13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther, 21(2), 179-185. PMID: 15679768

Festi, D.; Capodicasa, S.; Sandri, L.; et al. 2005. Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: comparison with Child-Pugh score and serum bile acid levels. World J Gastroenterol, 11(1), 142-148. PMID: 15609414. 

Mattison, L.K.; Ezzeldin, H.; Carpenter, M.; et al. 2004. Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. Clin Cancer Res, 10(8), 2652-2658. PMID: 15102667

Candelli, M.; Armuzzi, A.; Nista, E.C.; et al. 2004. 13C-methacetin breath test for monitoring hepatic function in cirrahotic patients before and after liver transplantation. Aliment Pharmacol Ther, 19(9), 243. PMID: 14723615.

Milazzo, L.; Piazza, M.; Sangaletti, O. et al. 2004. [13C] Methionine breath test: a novel method to detect antiretroviral drug-related mitochondrial toxicity. Journal of Antimicrobial Chemotherapy. 55, 84-89. PMID: 15590719

Petrolati, A.; Festi, D.; De Berardinis, G.; et al. 2003. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther, 18(8), 785-790. PMID: 14535871.

Lara Baruque, S.; Razquin, M.; Jimenez, I.; et al. 2000. 13C-phenylalanine and 13C-methacetin breath test to evaluate functional capacity of hepatocyte in chronic liver disease. Dig Liver Dis, 32(3), 226-232. PMID: 10975773. 

Ishii, Y.; Asai, S. Kohno, T. et al.  2000. Evaluation of Liver Regeneration Using the L-[1-13C]Methionine Breath Tests. Journal of Surgical Research. 95 (195-199). PMID:11162045

 

 

 

 

 

 

 

 

 

 

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