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The Enrichment of Isotopically Labeled Products

 

For isotopically labeled products, enrichment is shown as a percentage. Enrichment is specified per atom site, and is the percentage of labeled atoms at the given site. It may also be called “isotopic purity.” Enrichment does not indicate the percentage of fully labeled molecules in all cases. For instance, if only one site is labeled, enrichment does tell what percentage of the site is completely labeled. If more than one site is labeled, the enrichment per atom site will be greater than the percentage of fully labeled molecules. As the number of labeled sites in the molecules increases, the probability of finding a labeled atom at every labeled site decreases.

As an example, in DLM-349 D-Glucose (6,6-D2,99%) both positions at the sixth carbon are labeled to at least 99%. This does not mean that 99% of the molecules have two deuterium atoms. The percentage of molecules that are fully labeled is (0.99)2 or 98.01%; the percentage of molecules that are mono-deuterated is 2(0.99)(0.01) or 1.98% and the percentage of molecules that are undeuterated is (0.01)2 or 0.01%.

Isotopically labeled products
For our Isotopically labeled products, we show enrichment as a percentage. Enrichment is specified per atom site, and is the percentage of labeled atoms at the given site.
For our Isotopically labeled products, we show enrichment as a percentage. Enrichment is specified per atom site, and is the percentage of labeled atoms at the given site.