Partnerships

Testimonials

 

Meet a few of our customers, hear their stories and imagine what CIL can do for you.

 

 

Gary Patti, PhD

Associate Professor | Washington University | St. Louis

David Muddiman, PhD

Professor | Department of Chemistry | North Carolina University

Joshua J. Coon, PhD

University of Wisconsin-Madison

Jenny Van Eyk, PhD

Cedar-Sinai Medical Institute

John R. Yates III, PhD

The Scripps Research Institute, La Jolla, CA

Donald H. Chace, PhD, MSFS, FACB

Donald H. Chace, PhD, MSFS, FACB

Pediatrix Medical Group

"I have worked with CIL for more than 15 years to design and provide the best and most suitable stable isotope standards for the newborn and metabolic screening community. Their standards are the highest quality and customer service is excellent."

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Michael Burgess

Michael Burgess

Broad Institute, Cambridge, MA

“Using highly enriched materials decreases the amount of unlabeled analog introduced into the mass spectrometer. As a result, using 99% enriched amino acids will improve the accuracy and useful dynamic range for MS-based quantitative proteomic methods compared to using amino acids with lower enrichments.”

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Jamie Williamson, PhD

Jamie Williamson, PhD

NMR Spectroscopist

"CIL and Cassia have developed the most extensive product line of stable isotope-labeled RNA and DNA triphosphates, DNA phosphoramidites and other related compounds."

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Lila Gierasch, PhD

Lila Gierasch, PhD

University of Massachusetts Amherst

“We have been using CIL products for years and appreciate the competitive pricing, outstanding quality control, friendly customer service and timely delivery of the wide range of products that CIL provides for our protein folding and structural studies.”

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Pratip Bhattacharya, PhD

Pratip Bhattacharya, PhD

Huntington Medical Research Institutes

“Huntington Medical Research Institute thanks Cambridge Isotope for the support of its Enhanced Magnetic Resonance Program. CIL’s help was crucial in the molecular synthesis of the precursor of the first metabolic PHIP (Parahydrogen Induced Polarization) reagent for real-time hyperpolarized imaging and spectroscopy.”

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Michael Summers, PhD

Michael Summers, PhD

University of Maryland

“We’ve been using CIL’s perdeuterated rNTPs for many years to facilitate NMR studies of larger RNAs. Their newer products, which include partially deuterated rNTPs, have been extraordinarily helpful, and have enabled high resolution NMR structural studies of RNAs that were previously intractable.”

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Ravi P. Barnwal

Ravi P. Barnwal

University of Washington

“We have been a loyal customer of CIL for stable isotope-labeled products for our research in the study of proteins. CIL has provided reliable, in stock, high quality products for our lab. We have enjoyed a nice working relationship with CIL over the years.”

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Scott Turner, PhD

Scott Turner, PhD

KineMed, Inc.

“As the leading developer of stable isotope-based biomarkers, it is essential that we have reliable partners providing us with high-quality clinical and cGMP-grade materials. For over 10 years CIL has consistently provided us with high-quality clinical and research-grade stable isotope tracers for the development of our novel kinetic-based tests.”

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Joel B. Braunstein

Joel B. Braunstein

C2N Diagnostics

“We concluded that CIL is the best-positioned company in the world to meet our future expected demands in terms of both material quantity and material quality. As we expand the use of our SILK™-based biomarkers beyond research services and into clinical diagnostic applications, CIL will be an instrumental partner to help us qualify our test kits to produce L-leucine under GMP scaled-up conditions.”

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Paul Liberatore

Paul Liberatore

University of Rochester

"Cambridge Isotope Labs has been our supplier for deuterated NMR solvents for more than 15 years. CIL has been a reliable supplier of high quality deuterated solvents. Their knowledgeable and friendly customer service team is able to fill my orders in a timely manner. I have developed a great working relationship with CIL. I am able to pass that exceptional service onto the researchers in the chemistry department through competitive pricing and fast dependable delivery."

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Tom Harner

Tom Harner

The Air Quality Processes Research Section (ARQP) of Environment and Climate Change Canada (ECCC)

“The use of isotopically labeled standards is key to the work we do under the GAPS (Global Atmospheric Passive Sampling) Network, where we investigate both legacy POPs and new priority chemicals in air at the global-scale. The use of labeled standards helps to ensure the integrity of our analytical methods and for estimating sampling rates for our PUF disk passive air samplers. ”

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Samuel Butcher, PhD

Samuel Butcher, PhD

Department of Biochemistry | University of Wisconsin-Madison

“When my lab makes labeled RNA, we count on high yields and purity. We have been using 13C / 15N ribonucleotide triphosphates (rNTPs) and selectively deuterated rNTPs from CIL for the past 10 years. We have always been very happy with the performance and quality of the CIL rNTPs. They are the gold standard.” Dr. Samuel Butcher Department of Biochemistry University of Wisconsin-Madison

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Gabriel M. Simon, PhD

Gabriel M. Simon, PhD

Washington University, Dept. of Genome Studies

“The use of 15N Spirulina diet for generating SILAM mice was very straightforward and effective. The mice seemed to prefer the Spirulina chow to their normal diet, and behaved and bred normally over multiple generations while consuming this food. Labeling efficiency was very high (~98% enrichment) after only a single generation.”

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Michael J. MacCoss, PhD

Michael J. MacCoss, PhD

University of Washington, Dept. of Genome Studies

“To measure proteome-wide protein turnover in flies and mice we have used a synthetic diet enriched with L-Leucine (5,5,5-D3) from CIL. The material is extremely cost effective and because of the high frequency of leucine in tryptic peptides, it enables us to use isotopomer distribution analysis to correct for differences in the precursor pool. These are challenging experiments to perform, with lots of details to worry about. Thankfully we have never had to worry about the quality of our stable isotope-labeled material from CIL.”

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Matthew L. MacDonald, PhD

Matthew L. MacDonald, PhD

University of Pittsburgh, Translational Neuroscience Program

“The addition of SILAM standards prepared from CIL’s MouseExpress® brain tissue to subcellular fractionation and targeted LC-SRM/MS methodologies represents an essential powerful new tool for the study of neuropsychiatric illness.”

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Kristy J. Brown, PhD and Yetrib Hathout, PhD

Kristy J. Brown, PhD and Yetrib Hathout, PhD

Children's National Medical Center, Center for Genetic Medicine

“We have used the MouseExpress® L-Lysine (13C6, 99%) Mouse Feed Labeling Kit from Cambridge Isotope Labs (CIL) to label a colony of C57BL6 mice. We achieved full labeling efficiency by F2 generation in the muscle tissue, our tissue of interest, and in all other tissues tested. In addition, CIL’s MouseExpress® (15N, 98%) Mouse Feed was used in non-generational labeling of a colony of C57BL6 mice. We achieved full labeling efficiency after 12 weeks of feeding the MouseExpress® (15N, 98%) Mouse Feed. These labeled tissues are fueling a variety of studies for multiple principle investigators at our research institute to study Duchenne muscular dystrophy, myositis, urea cycle disorders and vanishing white matter disease. “

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Steven A. Carr, PhD

Steven A. Carr, PhD

Broad Institute of MIT and Harvard

“The commercial availability of stable isotope-labeled amino acids with very high isotopic purity has revolutionized quantitative proteomics. From their use in metabolic labeling of cells and rodents for differential discovery proteomics, to their use in synthetic peptides as internal standards for targeted analysis of proteins, isotopically labeled amino acids make it possible to measure, with very high precision, changes in the levels of peptides and the proteins they are derived from in highly complex samples such as cell lysates, tissue and plasma. Cambridge Isotope Labs has been and continues to be a leader in the commercial production of labeled amino acids and other labeled compounds.”

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Samuel Massoni, CEO

Samuel Massoni, CEO

New England Peptide, Inc.

“I have been dealing with Cambridge Isotope Labs for over a decade, and simply put, CIL is the best isotope company out there – best in quality, best in service...”

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Iain Pritchard, PhD

Iain Pritchard, PhD

Assistant Director of Production, Bachem UK Ltd., St. Helens, UK

“With their combination of high quality, extensive catalogue and excellent customer relations, CIL is always our first port of call when sourcing isotopically labelled protected amino acid derivatives.”

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Karsten Kuhn, PhD

Karsten Kuhn, PhD

Head of Chemistry, Proteome Sciences, Frankfurt, Germany

“Proteome Sciences has developed and manufactures the isobaric Tandem Mass Tag® (TMT®) reagents, which are sold under license by Thermo Fisher Scientific. TMT® reagents for MS-based proteomics investigations are used worldwide and represent one of our key business activities. To meet increased market needs and to make full advantage of latest MS instrument developments, we continuously evaluate improvement potential together with our partners and key opinion leaders. Heavy isotope-labeled building blocks are key to both guarantee a constant TMT® product supply to our licensee and to generate new prototypes and TMT® products. Since we started manufacturing TMT®’s in large scale in 2008, Cambridge Isotope Labs has consistently been a reliable partner who can provide us with bulk amounts of established precursors and supply custom-tailored precursors for improvement investigation. Their product quality both in chemical purity, isotope enrichment and delivery times have been a sustainable source for our business. We are looking forward to continuing our collaboration with CIL as we develop exciting new tags for enhanced mass spectrometry methods.”

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Fred E. Regnier, PhD

Fred E. Regnier, PhD

J.H. Law Distinguished Professor, Department of Chemistry, Purdue University

“We have come to depend on CIL to furnish us with high quality reagents during the past few years as our laboratory became interested in the synthesis of a series of isotopically labeled coding agents for quantification in both proteomics and metabolomics. CIL was both knowledgeable and helpful, being willing to listen to our problems and going to their technical staff for solutions. Relationships like this are infrequent today and extremely valuable when you need answers quickly.”

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Tero Pihlajamaa, PhD

Tero Pihlajamaa, PhD

Finnish Biological NMR Center, Institute of Biotechnology

“In our hands, CIL’s BioExpress® 1000 worked like a charm. The cell growth rate and protein expression level essentially matched the results obtained with Luria broth, and the 15N labeling efficiency was excellent.”

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Professor Yves Boirie

Professor Yves Boirie

Human Nutrition Unit – INRA / Université d'Auvergne

“Life is sustained by constant dynamic metabolic adaptations to environmental changes in healthy and disease states. This is the reason why stable isotope-labeled compounds help us to understand kinetics modifications. Thus, we are looking for ‘high quality’ products which can be used safely. Thanks to CIL products, which are delivered quickly after order, with purity analysis and quality control, we have been able to propose new concepts in nutrition. Thus, we are satisfied by their products.”

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Matthew Steinhauser, MD

Matthew Steinhauser, MD

Brigham and Women's Hospital, Harvard Medical School

“I have been extremely happy with all products and services that we’ve obtained from CIL. All stable isotope reagents have exceeded our expectations. We’ve also obtained custom services from CIL to complete some very challenging studies, and have found CIL flexible and willing to work with us to achieve our goals. In short, I have nothing but positive things to say about our experience with CIL and their products.”

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John W. Brock, PhD

John W. Brock, PhD

Professor

“In our early phthalate work at the CDC, Cambridge Isotope Labs provided custom 13C standards quickly and accurately. This allowed the scientists in my lab to do gound-breaking work on human exposures to phthalates that continues today. I thank the Environmental Contaminant Standards new product development team and those great synthetic chemists at CIL.”

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Julie Forman-Kay, PhD

Julie Forman-Kay, PhD

Senior Scientist, Professor

"We have been extremely pleased and satisfied with CIL, not only for their quality products and competitive prices, but for their prompt customer service, including getting quotes quickly and fast delivery."

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Diemut König-Greger, MSC

Diemut König-Greger, MSC

Global Commercial Manager

“For many years we have had a strong relationship with CIL. The heavy peptides AQUA standards we produce require the highest quality of raw material, service and technical support, and CIL never failed to deliver. When we asked CIL to adapt the specifications of their products so we could meet the needs of our customers, they reacted immediately, and within a couple of months they were ready to deliver.”

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Brian Vining, PhD

Brian Vining, PhD

Technical Director, SGS Analytical Perspectives

"We used CIL standards since the company's inception. CIL standards stand up well against any and all competition.

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Stéphane Blanc, PhD

Stéphane Blanc, PhD

Directeur Adjoint de l’Institut Pluridisciplinaire Hubert Curien

“Since 2003, we have been using CIL’s research products. We are always entirely satisfied with the quality and quick delivery time. CIL provides us with all the necessary test data for our pharmacist to use when approving the product for our studies.”

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Frans te Braake, PhD

Frans te Braake, PhD

Erasmus MC – Sophia Children’s Hospital

“CIL has greatly facilitated our clinical research by supplying specially designed labeled compounds. We have made great progress in our neonatal antioxidant research program by the provision of labeled glutathione by CIL.”

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George Brooks, PhD

George Brooks, PhD

Department of Integrative Biology, Exercise Physiology Lab, UC Berkeley

“I have used metabolic substrates from Cambridge Isotope Labs for nutrition and exercise physiology studies for two decades. I have been very pleased with the quality of the products and service provided by CIL.”

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Chien Ho, PhD

Chien Ho, PhD

Alumni Professor of Biological Sciences

“I have been a customer of Cambridge Isotope Laboratories for over 25 years and have been very satisfied with the quality of its products, such as D2O, isotopic labeled compounds, etc. I have also been very satisfied in my dealing with its staff and sales representatives. They are always very eager to help me and my colleagues in choosing the most appropriate materials at the most reasonable prices for our experiments. It has been a pleasure to work with CIL!”

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Tim Cross, PhD

Tim Cross, PhD

National High Magnetic Field Laboratory

“Several years ago CIL provided much-sought-after high-enrichment 17O-labeled water. This led to the development of very high-field 17O NMR spectroscopy of proteins. This greatly facilitated our research and has led to a number of recent publications that have pushed this field of research forward (e.g. Hu et al., 2005, JACS 127:11922; Chekmenev et al., 2006, BJ 91:3076).”

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Warwick B. Dunn, PhD

Warwick B. Dunn, PhD

University of Birmingham

“Metabolism has an essential role in biological systems. Identification and quantitation of the compounds in the metabolome is defined as metabolomics or metabolic profiling, and it is applied to define metabolic changes related to genetic differences, environmental influences and disease or drug perturbations.”

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Meena Garg, MD

Meena Garg, MD

Professor of Pediatrics

“I have been buying my supply of stable isotopes for metabolic research from Cambridge Isotope Labs since 2003. I like to buy my supplies from CIL because I can rely on a good price and prompt delivery. This service is made feasible by constant efforts of my representative, who keeps me well informed regarding availability issues and takes personal interest in making sure that I get it on time. On one occasion I ran out of materials unexpectedly and CIL accommodated my requirements so that experiments could be completed. I will continue to buy from CIL since I always know I will receive the best service, product quality and competitive prices.”

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Thomas C. Glenn, PhD

Thomas C. Glenn, PhD

Associate Adjunct Professor

“Since starting our clinical brain metabolism studies with CIL products in 2003, we have enjoyed an outstanding relationship with your company. The diversity and availability of 13C-labeled isotopes has been crucial for our research progress and subsequent funding from the National Institutes of Health. In addition to the high quality of your products, I have been very impressed with your and the company’s customer service. Your frequent visits to UCLA, the rapid response time to quote requests, and the feedback from CIL regarding shipping dates is much appreciated. I look forward to a long and productive relationship with you and Cambridge Isotope Labs."

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Christopher Lepre, PhD

Christopher Lepre, PhD

Research Fellow II, Structural Biology

“We use CIL because, in addition to their labeled media, they carry an extensive line of reagents for biomolecular NMR, such as buffers, detergents and reducing agents. They have also been quite helpful by adding new products in response to customer needs.”

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Yong-Ming Yu, PhD

Yong-Ming Yu, PhD

Shriner's Hospitals for Children – Boston

“CIL has solved many of our technical problems and custom made many isotopes supporting the advancement of stable isotope research in the metabolic field. Over the past 27 years, CIL has provided safe and reliable research products. CIL’s research products utilized in stable isotope-tracer techniques have played an important role in the fields of diabetes, obesity, exercise and AIDS research. In addition, CIL products were also extensively used in our long time investigation of amino acid requirements in health and diseased condition led by Dr. Vernon R.Young, which has led to global improvement of health. CIL also provides excellent customer services. The staffs are knowledgeable and are enthusiasm in discussing with the investigators and developing new products to serve the research communities. My 30-year collaboration with CIL has been a pleasant and productive experience. I would like to say thank you for the many years of research support you have provided.”

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Gaetano Montelione, PhD

Gaetano Montelione, PhD

Professor of Molecular Biology and Biochemistry

“CIL has been a strong supporter of NMR methods development over the years, providing critical isotope-enriched reagents for research and development, without which many of the recent advances in biomolecular NMR would simply not have been possible. In particular, the broad biological impact and tremendous success of multidimensional triple-resonance biomolecular NMR would not have been achieved without the high quality and broadly accessible reagents that CIL has provided to the scientific community over the last 20 years.”

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Prof. Hartmut Oschkinat, PhD

Prof. Hartmut Oschkinat, PhD

NMR-Supported Structural Biology

“The methodological development that NMR has been in the past six decades would not have been possible without close collaborations with companies that love to see progress happening. CIL is a particularly strong and supportive partner, and many ideas with respect to labelling pattern that looked crazy on the first sight became reality through CIL, enabling us to conquer new areas for NMR structure determination. There are a wide variety of examples where talking to CIL has pushed science forward.”

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Gottfried Otting, PhD

Gottfried Otting, PhD

Research School of Chemistry

“We recently found a way of cell-free protein synthesis from PCR-amplified DNA that gives sufficient yield for subsequent analysis of the protein by NMR spectroscopy. So now we can go from gene to NMR spectrum, including site-directed mutations, in a day. We have tested it with 13C/15N-isoleucine from CIL and it worked perfectly. I barely recognize myself – never set my eyes on isotope labeled amino acids like this before.”

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Akhilesh Pandey, PhD

Akhilesh Pandey, PhD

Johns Hopkins University

“Stable isotope labeling with amino acids in cell culture (SILAC) is a simple and straightforward approach for in vivo incorporation of a label into proteins for mass spectrometry (MS)-based quantitative proteomics. SILAC relies on metabolic incorporation of a given "light" (unlabeled) or "heavy" (labeled) form of the amino acid into the proteins. The method relies on the incorporation of amino acids with substituted stable isotopic nuclei (e.g. 13C, 15N). Thus in an experiment, two cell populations are grown in culture media that are identical except that one of them contains a “light” and the other a “heavy” form of a particular amino acid (e.g. 12C and 13C labeled L-Lysine, respectively). When the labeled analog of an amino acid is supplied to cells in culture instead of the natural amino acid, it is incorporated into all newly synthesized proteins. After a number of cell divisions, each instance of this particular amino acid will be replaced by its isotope-labeled analog. Since there is hardly any chemical difference between the labeled amino acid and the natural amino acid isotopes, the cells behave exactly like the control cell population grown in the presence of normal amino acid. It is efficient and reproducible as the incorporation of the isotope label is 100%. We anticipate that potential applications of SILAC will lead to its use as a routine technique in all areas of cell biology.”

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Jeffrey Peng, PhD

Jeffrey Peng, PhD

Assistant Professor, Department of Chemistry and Biochemistry

“Over the years, CIL has shown tremendous enthusiasm and expertise in working with researchers to develop the latest strategies in isotope labeling for bioNMR. They continue to do so. They have also been excellent in helping graduate students, post-docs and beginning investigators get started.”

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Chad Rienstra, PhD

Chad Rienstra, PhD

Chemistry Department, University of Illinois

“My research group develops solid-state NMR methods for protein structure determination, requiring large quantities of 13C, 15N-labeled samples produced in-house. We have been very pleased with CIL products for isotopically labeled protein expression, including glucose, glycerol, ammonium chloride, BioExpress® and specifically labeled amino acids. Using CIL products, we routinely obtain several milligrams of labeled membrane proteins per liter of E. coli and ten to hundreds of milligrams of water-soluble proteins. We especially appreciate the competitive pricing, outstanding quality control, friendly customer service and timely delivery of a wide range of in-stock products that CIL provides. At a time when many other vendors cut corners to earn business, it’s reassuring to know that CIL values its customers and never compromises product quality.”

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Jesse Rinehart, PhD

Jesse Rinehart, PhD

Assistant Professor, Yale University School of Medicine

“The heavy-labeled mouse tissue from CIL was extremely useful to validate labeled tissue produced in our own laboratory. We isolated peptides from the CIL tissue and ran our own independent analysis on a mass spectrometer. Based on these analyses we were confident to move forward with our proteomics experiments.”

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Prof. Dr. Harald Schwalbe

Prof. Dr. Harald Schwalbe

Institut für Organische Chemie

“We are very pleased with the quality of CIL’s BioExpress® 6000 media. The mammalian cell growth media from CIL provides an excellent opportunity to obtain isotope-labeled samples of eukaryotic proteins for NMR studies. When comparing CIL’s BioExpress® 6000 media with typical rich growth media no differences in growth or expression rates were found.”

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L.J.C. van Loon, PhD

L.J.C. van Loon, PhD

Associate Professor – Stable Isotope Research Laboratory

“Cambridge Isotope Laboratories has been our preferred supplier of stable isotopes for more than 15 years and has provided us with quality products and dedicated service.”

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Professor James R. Williamson

Professor James R. Williamson

The Skaggs Institute for Chemical Biology

“We have enjoyed a close working relationship with CIL for the last 15 years, both as a customer and a collaborator. We’ve had great interactions with sales, with the management and the chemists; from top to bottom CIL is a great company that you can really work with in this specialized area. We’ve been able to do science that we couldn’t have done without working with CIL.”

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Andrew Jones, PhD

Andrew Jones, PhD

VP Chemical Development, Concert Pharmaceuticals

“For the past decade CIL have consistently provided deuterated reagents and service of the highest quality to support our development needs. We look forward to continuing to work with CIL as we further advance our product pipeline.”

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Testimonials | Cambridge Isotope Laboratories
stable isotopes, CIL, stable isotope
Meet some of the loyal customers of Cambridge Isotope Laboratories as they share their experiences with our company and the stable isotopes we provide.