The emerging field of glycomics focuses on the structure and function of glycans in a cell, tissue, organism, or other living system. Glycans are chained carbohydrates (oligo or polysaccharides) that are free or conjugated to macromolecules, such as proteins (referred to as glycoproteins) or lipids (referred to as glycolipids). They participate in a diverse array of biological processes (e.g., cell signaling, protein folding, and immune recognition) and are implicated in a number of diseases (e.g., oncological, autoimmune, and Alzheimer's). While analytical methodologies for their detection and sequencing have advanced, glycomic research has been hampered by the lack of commercially available standards and research tools.
Cambridge Isotope Laboratories, Inc. (CIL) is pleased to offer standards/tools to the glycomic research community to aid the detection, identification, and quantification of glycans in biological samples. Specifically, CIL is now supplying authentic glycan standards for use as internal standards for mass spectrometry and as starting materials for use in glyco-microarrays. Additionally, CIL is pleased to offer an innovative glycan-tagging kit termed INLIGHT® (Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tag) for use in relative quantitative comparisons of N-glycans between two samples.